These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

314 related articles for article (PubMed ID: 25466281)

  • 1. Lysosomal enzyme cathepsin B enhances the aggregate forming activity of exogenous α-synuclein fibrils.
    Tsujimura A; Taguchi K; Watanabe Y; Tatebe H; Tokuda T; Mizuno T; Tanaka M
    Neurobiol Dis; 2015 Jan; 73():244-53. PubMed ID: 25466281
    [TBL] [Abstract][Full Text] [Related]  

  • 2. C-terminal α-synuclein truncations are linked to cysteine cathepsin activity in Parkinson's disease.
    McGlinchey RP; Lacy SM; Huffer KE; Tayebi N; Sidransky E; Lee JC
    J Biol Chem; 2019 Jun; 294(25):9973-9984. PubMed ID: 31092553
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Cysteine cathepsins are essential in lysosomal degradation of α-synuclein.
    McGlinchey RP; Lee JC
    Proc Natl Acad Sci U S A; 2015 Jul; 112(30):9322-7. PubMed ID: 26170293
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies.
    Karpowicz RJ; Haney CM; Mihaila TS; Sandler RM; Petersson EJ; Lee VM
    J Biol Chem; 2017 Aug; 292(32):13482-13497. PubMed ID: 28611062
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The effect of fluorescent labeling on α-synuclein fibril morphology.
    Mučibabić M; Apetri MM; Canters GW; Aartsma TJ
    Biochim Biophys Acta; 2016 Oct; 1864(10):1419-27. PubMed ID: 27475048
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Oxidative stress-induced phosphorylation, degradation and aggregation of alpha-synuclein are linked to upregulated CK2 and cathepsin D.
    Takahashi M; Ko LW; Kulathingal J; Jiang P; Sevlever D; Yen SH
    Eur J Neurosci; 2007 Aug; 26(4):863-74. PubMed ID: 17714183
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Over-expression of an inactive mutant cathepsin D increases endogenous alpha-synuclein and cathepsin B activity in SH-SY5Y cells.
    Crabtree D; Dodson M; Ouyang X; Boyer-Guittaut M; Liang Q; Ballestas ME; Fineberg N; Zhang J
    J Neurochem; 2014 Mar; 128(6):950-61. PubMed ID: 24138030
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Cathepsin K is a potent disaggregase of α-synuclein fibrils.
    McGlinchey RP; Lacy SM; Walker RL; Lee JC
    Biochem Biophys Res Commun; 2020 Sep; 529(4):1106-1111. PubMed ID: 32819572
    [TBL] [Abstract][Full Text] [Related]  

  • 9. α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity.
    Ghanem SS; Majbour NK; Vaikath NN; Ardah MT; Erskine D; Jensen NM; Fayyad M; Sudhakaran IP; Vasili E; Melachroinou K; Abdi IY; Poggiolini I; Santos P; Dorn A; Carloni P; Vekrellis K; Attems J; McKeith I; Outeiro TF; Jensen PH; El-Agnaf OMA
    Proc Natl Acad Sci U S A; 2022 Apr; 119(15):e2109617119. PubMed ID: 35353605
    [TBL] [Abstract][Full Text] [Related]  

  • 10. C-terminal truncation exacerbates the aggregation and cytotoxicity of α-Synuclein: A vicious cycle in Parkinson's disease.
    Ma L; Yang C; Zhang X; Li Y; Wang S; Zheng L; Huang K
    Biochim Biophys Acta Mol Basis Dis; 2018 Dec; 1864(12):3714-3725. PubMed ID: 30290273
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Potent prion-like behaviors of pathogenic α-synuclein and evaluation of inactivation methods.
    Tarutani A; Arai T; Murayama S; Hisanaga SI; Hasegawa M
    Acta Neuropathol Commun; 2018 Apr; 6(1):29. PubMed ID: 29669601
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Analysis of sheep α-synuclein provides a molecular strategy for the reduction of fibrillation.
    Bickle L; Hopwood JJ; Karageorgos L
    Biochim Biophys Acta Proteins Proteom; 2017 Mar; 1865(3):261-273. PubMed ID: 28007442
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Small molecule-based fluorescent probes for the detection of α-Synuclein aggregation states.
    Haque R; Maity D
    Bioorg Med Chem Lett; 2023 Apr; 86():129257. PubMed ID: 36966976
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Extracellular α-synuclein impairs sphingosine 1-phosphate receptor type 3 (S1PR3)-regulated lysosomal delivery of cathepsin D in HeLa cells.
    Nishida S; Matovelo SA; Kajimoto T; Nakamura SI; Okada T
    Genes Cells; 2024 Mar; 29(3):207-216. PubMed ID: 38163647
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The Molecular Chaperone DNAJB6, but Not DNAJB1, Suppresses the Seeded Aggregation of Alpha-Synuclein in Cells.
    Deshayes N; Arkan S; Hansen C
    Int J Mol Sci; 2019 Sep; 20(18):. PubMed ID: 31514384
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Impaired endo-lysosomal membrane integrity accelerates the seeding progression of α-synuclein aggregates.
    Jiang P; Gan M; Yen SH; McLean PJ; Dickson DW
    Sci Rep; 2017 Aug; 7(1):7690. PubMed ID: 28794446
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Physiological C-terminal truncation of α-synuclein potentiates the prion-like formation of pathological inclusions.
    Sorrentino ZA; Vijayaraghavan N; Gorion KM; Riffe CJ; Strang KH; Caldwell J; Giasson BI
    J Biol Chem; 2018 Dec; 293(49):18914-18932. PubMed ID: 30327435
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts.
    Ardah MT; Ghanem SS; Abdulla SA; Lv G; Emara MM; Paleologou KE; Vaikath NN; Lu JH; Li M; Vekrellis K; Eliezer D; El-Agnaf OMA
    BMC Complement Med Ther; 2020 Mar; 20(1):73. PubMed ID: 32143619
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A simple, versatile and robust centrifugation-based filtration protocol for the isolation and quantification of α-synuclein monomers, oligomers and fibrils: Towards improving experimental reproducibility in α-synuclein research.
    Kumar ST; Donzelli S; Chiki A; Syed MMK; Lashuel HA
    J Neurochem; 2020 Apr; 153(1):103-119. PubMed ID: 31925956
    [TBL] [Abstract][Full Text] [Related]  

  • 20. α-Synuclein aggregation at low concentrations.
    Afitska K; Fucikova A; Shvadchak VV; Yushchenko DA
    Biochim Biophys Acta Proteins Proteom; 2019; 1867(7-8):701-709. PubMed ID: 31096048
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.