BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

237 related articles for article (PubMed ID: 2547072)

  • 1. Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine.
    Balzarini J; Baumgartner H; Bodenteich M; De Clercq E; Griengl H
    J Med Chem; 1989 Aug; 32(8):1861-5. PubMed ID: 2547072
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Carbocyclic 5-iodo-2'-deoxyuridine (C-IDU) and carbocyclic (E)-5-(2-bromovinyl)-2'-deoxyuridine (C-BVDU) as unique examples of chiral molecules where the two enantiomeric forms are biologically active: interaction of the (+)- and (-)-enantiomers of C-IDU and C-BVDU with the thymidine kinase of herpes simplex virus type 1.
    Balzarini J; De Clercq E; Baumgartner H; Bodenteich M; Griengl H
    Mol Pharmacol; 1990 Mar; 37(3):395-401. PubMed ID: 2156153
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.
    Herdewijn P; De Clercq E; Balzarini J; Vanderhaeghe H
    J Med Chem; 1985 May; 28(5):550-5. PubMed ID: 2985782
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Phosphonoformate and phosphonoacetate derivatives of 5-substituted 2'-deoxyuridines: synthesis and antiviral activity.
    Griengl H; Hayden W; Penn G; De Clercq E; Rosenwirth B
    J Med Chem; 1988 Sep; 31(9):1831-9. PubMed ID: 2842506
    [TBL] [Abstract][Full Text] [Related]  

  • 5. 5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication.
    Wigerinck P; Pannecouque C; Snoeck R; Claes P; De Clercq E; Herdewijn P
    J Med Chem; 1991 Aug; 34(8):2383-9. PubMed ID: 1652017
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Highly selective cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine derivatives for murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 thymidine kinase gene.
    Balzarini J; De Clercq E; Verbruggen A; Ayusawa D; Seno T
    Mol Pharmacol; 1985 Dec; 28(6):581-7. PubMed ID: 3001499
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and biological activity of 5-(2,2-difluorocyclopropyl)-2'-deoxyuridine deoxyuridine diastereomers.
    Tandon M; Singh S; Xu L; Kumar P; Wiebe LI; Knaus EE; Gati WP; Tempest ML
    Drug Des Discov; 1992; 9(1):79-91. PubMed ID: 1333829
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Thymidylate synthase is the principal target enzyme for the cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine against murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 or type 2 thymidine kinase gene.
    Balzarini J; De Clercq E; Verbruggen A; Ayusawa D; Shimizu K; Seno T
    Mol Pharmacol; 1987 Sep; 32(3):410-6. PubMed ID: 2823092
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Analysis of the thymidine kinase of a herpes simplex virus type 1 isolate that exhibits resistance to (E)-5-(2-bromovinyl)-2'-deoxyuridine.
    Wilber BA; Docherty JJ
    J Gen Virol; 1994 Jul; 75 ( Pt 7)():1743-7. PubMed ID: 8021603
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Stereoelectronic properties of five anti-HSV-1 2'-deoxynucleosides analogues with heterocyclic substituents in the 5-position: a comparison with BVDU.
    Olivier A; Creuven I; Evrard C; Evrard G; Dory M; van Aerschot A; Wigerinck P; Herdewijn P; Durant F
    Antiviral Res; 1994 Aug; 24(4):289-304. PubMed ID: 7993074
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.
    De Clercq E; Desgranges C; Herdewijn P; Sim IS; Jones AS; McLean MJ; Walker RT
    J Med Chem; 1986 Feb; 29(2):213-7. PubMed ID: 3005566
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis and antiviral properties of 5-vinylpyrimidine nucleoside analogs.
    De Clercq E; Walker RT
    Pharmacol Ther; 1984; 26(1):1-44. PubMed ID: 6099893
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Herpes simplex virus type 1 that exhibits herpes simplex virus type 2 sensitivity to (E)-5-(2-bromovinyl)-2'-deoxyuridine.
    Docherty JJ; Dobson AT; Trimble JJ; Jennings BA
    Intervirology; 1991; 32(5):308-15. PubMed ID: 1657822
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis and antiviral properties of (Z)-5-(2-bromovinyl)-2'-deoxyuridine.
    Jones AS; Rahim SG; Walker RT; De Clercq E
    J Med Chem; 1981 Jun; 24(6):759-60. PubMed ID: 6265638
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Problems associated with the use of (E)-5-(2-bromovinyl)-2'-deoxyuridine for typing herpes simplex virus.
    Swierkosz EM; Arens MQ; Rivetna KA
    J Clin Microbiol; 1985 Mar; 21(3):459-61. PubMed ID: 2984249
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis of the diastereomers of 5-(2,2-dichlorocyclopropyl)- and 5-(2-chlorocyclopropyl)-2'-deoxyuridine, and the antiviral and cytotoxic activity of these and bromo analogues.
    Tandon M; Singh S; Wiebe LI; Knaus EE; Gati WP; Tempest ML
    Drug Des Deliv; 1991 Jul; 7(4):295-307. PubMed ID: 1657019
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Selective antiherpetic activity of carbocyclic analogues of (E)-5-(2-halogenovinyl)-2'-deoxyuridines: dependence on specific phosphorylation by viral thymidine kinase.
    De Clercq E; Balzarini J; Bernaerts R; Herdewijn P; Verbruggen A
    Biochem Biophys Res Commun; 1985 Jan; 126(1):397-403. PubMed ID: 2982373
    [TBL] [Abstract][Full Text] [Related]  

  • 18. 5-Iodo-2'-deoxy-L-uridine and (E)-5-(2-bromovinyl)-2'-deoxy-L-uridine: selective phosphorylation by herpes simplex virus type 1 thymidine kinase, antiherpetic activity, and cytotoxicity studies.
    Spadari S; Ciarrocchi G; Focher F; Verri A; Maga G; Arcamone F; Iafrate E; Manzini S; Garbesi A; Tondelli L
    Mol Pharmacol; 1995 Jun; 47(6):1231-8. PubMed ID: 7603465
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibitory effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and related compounds on herpes simplex virus (HSV)-infected cells and HSV thymidine kinase gene-transformed cells.
    Balzarini J; De Clercq E
    Methods Find Exp Clin Pharmacol; 1989 Jun; 11(6):379-89. PubMed ID: 2545982
    [No Abstract]   [Full Text] [Related]  

  • 20. Selection of L cell sublines resistant to (E)-5-(2-bromovinyl)-2'-deoxyuridine.
    Shiraki K; Vonka V; De Clercq E; Rapp F
    Intervirology; 1991; 32(4):228-33. PubMed ID: 1650764
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.