292 related articles for article (PubMed ID: 25474122)
1. Approaches to Interchain Cysteine-Linked ADC Characterization by Mass Spectrometry.
Valliere-Douglass JF; Hengel SM; Pan LY
Mol Pharm; 2015 Jun; 12(6):1774-83. PubMed ID: 25474122
[TBL] [Abstract][Full Text] [Related]
2. Conformation and dynamics of interchain cysteine-linked antibody-drug conjugates as revealed by hydrogen/deuterium exchange mass spectrometry.
Pan LY; Salas-Solano O; Valliere-Douglass JF
Anal Chem; 2014 Mar; 86(5):2657-64. PubMed ID: 24512515
[TBL] [Abstract][Full Text] [Related]
3. Antibody structural integrity of site-specific antibody-drug conjugates investigated by hydrogen/deuterium exchange mass spectrometry.
Pan LY; Salas-Solano O; Valliere-Douglass JF
Anal Chem; 2015 Jun; 87(11):5669-76. PubMed ID: 25938577
[TBL] [Abstract][Full Text] [Related]
4. Native intact mass determination of antibodies conjugated with monomethyl Auristatin E and F at interchain cysteine residues.
Valliere-Douglass JF; McFee WA; Salas-Solano O
Anal Chem; 2012 Mar; 84(6):2843-9. PubMed ID: 22384990
[TBL] [Abstract][Full Text] [Related]
5. Insights from native mass spectrometry approaches for top- and middle- level characterization of site-specific antibody-drug conjugates.
Botzanowski T; Erb S; Hernandez-Alba O; Ehkirch A; Colas O; Wagner-Rousset E; Rabuka D; Beck A; Drake PM; Cianférani S
MAbs; 2017 Jul; 9(5):801-811. PubMed ID: 28406343
[TBL] [Abstract][Full Text] [Related]
6. Innovative native MS methodologies for antibody drug conjugate characterization: High resolution native MS and IM-MS for average DAR and DAR distribution assessment.
Debaene F; Boeuf A; Wagner-Rousset E; Colas O; Ayoub D; Corvaïa N; Van Dorsselaer A; Beck A; Cianférani S
Anal Chem; 2014 Nov; 86(21):10674-83. PubMed ID: 25270580
[TBL] [Abstract][Full Text] [Related]
7. Measurement of in vivo drug load distribution of cysteine-linked antibody-drug conjugates using microscale liquid chromatography mass spectrometry.
Hengel SM; Sanderson R; Valliere-Douglass J; Nicholas N; Leiske C; Alley SC
Anal Chem; 2014 Apr; 86(7):3420-5. PubMed ID: 24576206
[TBL] [Abstract][Full Text] [Related]
8. Characterization of antibody drug conjugate positional isomers at cysteine residues by peptide mapping LC-MS analysis.
Janin-Bussat MC; Dillenbourg M; Corvaia N; Beck A; Klinguer-Hamour C
J Chromatogr B Analyt Technol Biomed Life Sci; 2015 Feb; 981-982():9-13. PubMed ID: 25596378
[TBL] [Abstract][Full Text] [Related]
9. The Properties of Cysteine-Conjugated Antibody-Drug Conjugates Are Impacted by the IgG Subclass.
Datta-Mannan A; Choi H; Stokell D; Tang J; Murphy A; Wrobleski A; Feng Y
AAPS J; 2018 Sep; 20(6):103. PubMed ID: 30255287
[TBL] [Abstract][Full Text] [Related]
10. Characterization and Higher-Order Structure Assessment of an Interchain Cysteine-Based ADC: Impact of Drug Loading and Distribution on the Mechanism of Aggregation.
Guo J; Kumar S; Chipley M; Marcq O; Gupta D; Jin Z; Tomar DS; Swabowski C; Smith J; Starkey JA; Singh SK
Bioconjug Chem; 2016 Mar; 27(3):604-15. PubMed ID: 26829368
[TBL] [Abstract][Full Text] [Related]
11. A rapid on-line method for mass spectrometric confirmation of a cysteine-conjugated antibody-drug-conjugate structure using multidimensional chromatography.
Birdsall RE; Shion H; Kotch FW; Xu A; Porter TJ; Chen W
MAbs; 2015; 7(6):1036-44. PubMed ID: 26305867
[TBL] [Abstract][Full Text] [Related]
12. Characterization of Positional Isomers of Interchain Cysteine Linked Antibody-Drug Conjugates by High-Resolution Mass Spectrometry.
Li K; Lin ZJ; Shi H; Ma Y
Anal Chem; 2019 Jul; 91(13):8558-8563. PubMed ID: 31247726
[TBL] [Abstract][Full Text] [Related]
13. Rational design, biophysical and biological characterization of site-specific antibody-tubulysin conjugates with improved stability, efficacy and pharmacokinetics.
Thompson P; Fleming R; Bezabeh B; Huang F; Mao S; Chen C; Harper J; Zhong H; Gao X; Yu XQ; Hinrichs MJ; Reed M; Kamal A; Strout P; Cho S; Woods R; Hollingsworth RE; Dixit R; Wu H; Gao C; Dimasi N
J Control Release; 2016 Aug; 236():100-16. PubMed ID: 27327768
[TBL] [Abstract][Full Text] [Related]
14. Cutting-edge mass spectrometry methods for the multi-level structural characterization of antibody-drug conjugates.
Beck A; Terral G; Debaene F; Wagner-Rousset E; Marcoux J; Janin-Bussat MC; Colas O; Van Dorsselaer A; Cianférani S
Expert Rev Proteomics; 2016; 13(2):157-83. PubMed ID: 26653789
[TBL] [Abstract][Full Text] [Related]
15. Characterization of cysteine-linked conjugation profiles of immunoglobulin G1 and immunoglobulin G2 antibody-drug conjugates.
Wiggins B; Liu-Shin L; Yamaguchi H; Ratnaswamy G
J Pharm Sci; 2015 Apr; 104(4):1362-72. PubMed ID: 25631158
[TBL] [Abstract][Full Text] [Related]
16. Native size-exclusion chromatography-mass spectrometry: suitability for antibody-drug conjugate drug-to-antibody ratio quantitation across a range of chemotypes and drug-loading levels.
Jones J; Pack L; Hunter JH; Valliere-Douglass JF
MAbs; 2020; 12(1):1682895. PubMed ID: 31769727
[TBL] [Abstract][Full Text] [Related]
17. Analysis of ADCs by Native Mass Spectrometry.
Hernandez-Alba O; Ehkirch A; Beck A; Cianférani S
Methods Mol Biol; 2020; 2078():197-211. PubMed ID: 31643058
[TBL] [Abstract][Full Text] [Related]
18. Impact of drug conjugation on pharmacokinetics and tissue distribution of anti-STEAP1 antibody-drug conjugates in rats.
Boswell CA; Mundo EE; Zhang C; Bumbaca D; Valle NR; Kozak KR; Fourie A; Chuh J; Koppada N; Saad O; Gill H; Shen BQ; Rubinfeld B; Tibbitts J; Kaur S; Theil FP; Fielder PJ; Khawli LA; Lin K
Bioconjug Chem; 2011 Oct; 22(10):1994-2004. PubMed ID: 21913715
[TBL] [Abstract][Full Text] [Related]
19. Practical approaches for overcoming challenges in heightened characterization of antibody-drug conjugates with new methodologies and ultrahigh-resolution mass spectrometry.
Friese OV; Smith JN; Brown PW; Rouse JC
MAbs; 2018 Apr; 10(3):335-345. PubMed ID: 29393747
[TBL] [Abstract][Full Text] [Related]
20. Characterization of the Primary Structure of Cysteine-Linked Antibody-Drug Conjugates Using Capillary Electrophoresis with Mass Spectrometry.
Saadé J; Gahoual R; Beck A; Leize-Wagner E; François YN
Methods Mol Biol; 2020; 2078():263-272. PubMed ID: 31643063
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]