127 related articles for article (PubMed ID: 25478842)
1. A cautionary tale of structure-guided inhibitor development against an essential enzyme in the aspartate-biosynthetic pathway.
Pavlovsky AG; Thangavelu B; Bhansali P; Viola RE
Acta Crystallogr D Biol Crystallogr; 2014 Dec; 70(Pt 12):3244-52. PubMed ID: 25478842
[TBL] [Abstract][Full Text] [Related]
2. Structural characterization of inhibitors with selectivity against members of a homologous enzyme family.
Pavlovsky AG; Liu X; Faehnle CR; Potente N; Viola RE
Chem Biol Drug Des; 2012 Jan; 79(1):128-36. PubMed ID: 22039970
[TBL] [Abstract][Full Text] [Related]
3. The structure of a redundant enzyme: a second isoform of aspartate beta-semialdehyde dehydrogenase in Vibrio cholerae.
Viola RE; Liu X; Ohren JF; Faehnle CR
Acta Crystallogr D Biol Crystallogr; 2008 Mar; 64(Pt 3):321-30. PubMed ID: 18323627
[TBL] [Abstract][Full Text] [Related]
4. Elaboration of a fragment library hit produces potent and selective aspartate semialdehyde dehydrogenase inhibitors.
Thangavelu B; Bhansali P; Viola RE
Bioorg Med Chem; 2015 Oct; 23(20):6622-31. PubMed ID: 26404410
[TBL] [Abstract][Full Text] [Related]
5. Molecular docking and enzymatic evaluation to identify selective inhibitors of aspartate semialdehyde dehydrogenase.
Luniwal A; Wang L; Pavlovsky A; Erhardt PW; Viola RE
Bioorg Med Chem; 2012 May; 20(9):2950-6. PubMed ID: 22464683
[TBL] [Abstract][Full Text] [Related]
6. Identification of selective enzyme inhibitors by fragment library screening.
Gao G; Liu X; Pavlovsky A; Viola RE
J Biomol Screen; 2010 Oct; 15(9):1042-50. PubMed ID: 20855558
[TBL] [Abstract][Full Text] [Related]
7. Structural insights into inhibitor binding to a fungal ortholog of aspartate semialdehyde dehydrogenase.
Dahal GP; Viola RE
Biochem Biophys Res Commun; 2018 Sep; 503(4):2848-2854. PubMed ID: 30107909
[TBL] [Abstract][Full Text] [Related]
8. Shape-based virtual screening, docking, and molecular dynamics simulations to identify Mtb-ASADH inhibitors.
Kumar R; Garg P; Bharatam PV
J Biomol Struct Dyn; 2015; 33(5):1082-93. PubMed ID: 24875451
[TBL] [Abstract][Full Text] [Related]
9. A structural basis for the mechanism of aspartate-beta-semialdehyde dehydrogenase from Vibrio cholerae.
Blanco J; Moore RA; Kabaleeswaran V; Viola RE
Protein Sci; 2003 Jan; 12(1):27-33. PubMed ID: 12493825
[TBL] [Abstract][Full Text] [Related]
10. Structures of ternary complexes of aspartate-semialdehyde dehydrogenase (Rv3708c) from Mycobacterium tuberculosis H37Rv.
Vyas R; Tewari R; Weiss MS; Karthikeyan S
Acta Crystallogr D Biol Crystallogr; 2012 Jun; 68(Pt 6):671-9. PubMed ID: 22683789
[TBL] [Abstract][Full Text] [Related]
11. Expansion of the aspartate beta-semialdehyde dehydrogenase family: the first structure of a fungal ortholog.
Arachea BT; Liu X; Pavlovsky AG; Viola RE
Acta Crystallogr D Biol Crystallogr; 2010 Feb; 66(Pt 2):205-12. PubMed ID: 20124701
[TBL] [Abstract][Full Text] [Related]
12. Structural-functional analysis of drug target aspartate semialdehyde dehydrogenase.
Kumar R; R R; Diwakar V; Khan N; Kumar Meghwanshi G; Garg P
Drug Discov Today; 2024 Mar; 29(3):103908. PubMed ID: 38301800
[TBL] [Abstract][Full Text] [Related]
13. Active site analysis of the potential antimicrobial target aspartate semialdehyde dehydrogenase.
Hadfield A; Shammas C; Kryger G; Ringe D; Petsko GA; Ouyang J; Viola RE
Biochemistry; 2001 Dec; 40(48):14475-83. PubMed ID: 11724560
[TBL] [Abstract][Full Text] [Related]
14. Structure of aspartate-beta-semialdehyde dehydrogenase from Escherichia coli, a key enzyme in the aspartate family of amino acid biosynthesis.
Hadfield A; Kryger G; Ouyang J; Petsko GA; Ringe D; Viola R
J Mol Biol; 1999 Jun; 289(4):991-1002. PubMed ID: 10369777
[TBL] [Abstract][Full Text] [Related]
15. A Fragment Library Screening Approach to Identify Selective Inhibitors against an Essential Fungal Enzyme.
Dahal GP; Viola RE
SLAS Discov; 2018 Jul; 23(6):520-531. PubMed ID: 29608391
[TBL] [Abstract][Full Text] [Related]
16. Critical catalytic functional groups in the mechanism of aspartate-beta-semialdehyde dehydrogenase.
Blanco J; Moore RA; Faehnle CR; Viola RE
Acta Crystallogr D Biol Crystallogr; 2004 Oct; 60(Pt 10):1808-15. PubMed ID: 15388927
[TBL] [Abstract][Full Text] [Related]
17. Examination of key intermediates in the catalytic cycle of aspartate-beta-semialdehyde dehydrogenase from a gram-positive infectious bacteria.
Faehnle CR; Le Coq J; Liu X; Viola RE
J Biol Chem; 2006 Oct; 281(41):31031-40. PubMed ID: 16895909
[TBL] [Abstract][Full Text] [Related]
18. Capture of an intermediate in the catalytic cycle of L-aspartate-beta-semialdehyde dehydrogenase.
Blanco J; Moore RA; Viola RE
Proc Natl Acad Sci U S A; 2003 Oct; 100(22):12613-7. PubMed ID: 14559965
[TBL] [Abstract][Full Text] [Related]
19. Synthesis and evaluation of conformationally restricted inhibitors of aspartate semialdehyde dehydrogenase.
Evitt AS; Cox RJ
Mol Biosyst; 2011 May; 7(5):1564-75. PubMed ID: 21369577
[TBL] [Abstract][Full Text] [Related]
20. Structural basis for discrimination between oxyanion substrates or inhibitors in aspartate-beta-semialdehyde dehydrogenase.
Faehnle CR; Blanco J; Viola RE
Acta Crystallogr D Biol Crystallogr; 2004 Dec; 60(Pt 12 Pt 2):2320-4. PubMed ID: 15583380
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
