These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
255 related articles for article (PubMed ID: 25480923)
1. A systematic comparison of the impact of inflammatory signaling on absorption, distribution, metabolism, and excretion gene expression and activity in primary human hepatocytes and HepaRG cells. Klein M; Thomas M; Hofmann U; Seehofer D; Damm G; Zanger UM Drug Metab Dispos; 2015 Feb; 43(2):273-83. PubMed ID: 25480923 [TBL] [Abstract][Full Text] [Related]
2. HepaRG cells as human-relevant in vitro model to study the effects of inflammatory stimuli on cytochrome P450 isoenzymes. Rubin K; Janefeldt A; Andersson L; Berke Z; Grime K; Andersson TB Drug Metab Dispos; 2015 Jan; 43(1):119-25. PubMed ID: 25371393 [TBL] [Abstract][Full Text] [Related]
3. Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells. Anthérieu S; Chesné C; Li R; Camus S; Lahoz A; Picazo L; Turpeinen M; Tolonen A; Uusitalo J; Guguen-Guillouzo C; Guillouzo A Drug Metab Dispos; 2010 Mar; 38(3):516-25. PubMed ID: 20019244 [TBL] [Abstract][Full Text] [Related]
4. HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro. Lübberstedt M; Müller-Vieira U; Mayer M; Biemel KM; Knöspel F; Knobeloch D; Nüssler AK; Gerlach JC; Zeilinger K J Pharmacol Toxicol Methods; 2011; 63(1):59-68. PubMed ID: 20460162 [TBL] [Abstract][Full Text] [Related]
5. Comparison of Drug Metabolism and Its Related Hepatotoxic Effects in HepaRG, Cryopreserved Human Hepatocytes, and HepG2 Cell Cultures. Yokoyama Y; Sasaki Y; Terasaki N; Kawataki T; Takekawa K; Iwase Y; Shimizu T; Sanoh S; Ohta S Biol Pharm Bull; 2018 May; 41(5):722-732. PubMed ID: 29445054 [TBL] [Abstract][Full Text] [Related]
6. Baseline and genotoxic compound induced gene expression profiles in HepG2 and HepaRG compared to primary human hepatocytes. Jetten MJ; Kleinjans JC; Claessen SM; Chesné C; van Delft JH Toxicol In Vitro; 2013 Oct; 27(7):2031-40. PubMed ID: 23911569 [TBL] [Abstract][Full Text] [Related]
7. In vitro evaluation of hepatotoxic drugs in human hepatocytes from multiple donors: Identification of P450 activity as a potential risk factor for drug-induced liver injuries. Utkarsh D; Loretz C; Li AP Chem Biol Interact; 2016 Aug; 255():12-22. PubMed ID: 26718876 [TBL] [Abstract][Full Text] [Related]
8. Effect of interferon-α2b on the expression of various drug-metabolizing enzymes and transporters in co-cultures of freshly prepared human primary hepatocytes. Chen C; Han YH; Yang Z; Rodrigues AD Xenobiotica; 2011 Jun; 41(6):476-85. PubMed ID: 21381897 [TBL] [Abstract][Full Text] [Related]
9. Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells. Aninat C; Piton A; Glaise D; Le Charpentier T; Langouët S; Morel F; Guguen-Guillouzo C; Guillouzo A Drug Metab Dispos; 2006 Jan; 34(1):75-83. PubMed ID: 16204462 [TBL] [Abstract][Full Text] [Related]
10. Optimisation of the HepaRG cell line model for drug toxicity studies using two different cultivation conditions: advantages and limitations. Hammour MM; Othman A; Aspera-Werz R; Braun B; Weis-Klemm M; Wagner S; Nadalin S; Histing T; Ruoß M; Nüssler AK Arch Toxicol; 2022 Sep; 96(9):2511-2521. PubMed ID: 35748891 [TBL] [Abstract][Full Text] [Related]
11. Metronidazole reduces the expression of cytochrome P450 enzymes in HepaRG cells and cryopreserved human hepatocytes. Kudo T; Endo Y; Taguchi R; Yatsu M; Ito K Xenobiotica; 2015 May; 45(5):413-9. PubMed ID: 25470432 [TBL] [Abstract][Full Text] [Related]
12. Evaluation of HepaRG cells as an in vitro model for human drug metabolism studies. Kanebratt KP; Andersson TB Drug Metab Dispos; 2008 Jul; 36(7):1444-52. PubMed ID: 18385292 [TBL] [Abstract][Full Text] [Related]
13. Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor. Duret C; Daujat-Chavanieu M; Pascussi JM; Pichard-Garcia L; Balaguer P; Fabre JM; Vilarem MJ; Maurel P; Gerbal-Chaloin S Mol Pharmacol; 2006 Jul; 70(1):329-39. PubMed ID: 16608920 [TBL] [Abstract][Full Text] [Related]
14. Human Hepatic HepaRG Cells Maintain an Organotypic Phenotype with High Intrinsic CYP450 Activity/Metabolism and Significantly Outperform Standard HepG2/C3A Cells for Pharmaceutical and Therapeutic Applications. Nelson LJ; Morgan K; Treskes P; Samuel K; Henderson CJ; LeBled C; Homer N; Grant MH; Hayes PC; Plevris JN Basic Clin Pharmacol Toxicol; 2017 Jan; 120(1):30-37. PubMed ID: 27285124 [TBL] [Abstract][Full Text] [Related]
15. The JAK1/2 Inhibitor Ruxolitinib Reverses Interleukin-6-Mediated Suppression of Drug-Detoxifying Proteins in Cultured Human Hepatocytes. Febvre-James M; Bruyère A; Le Vée M; Fardel O Drug Metab Dispos; 2018 Feb; 46(2):131-140. PubMed ID: 29162613 [TBL] [Abstract][Full Text] [Related]
16. In vitro investigations into the roles of drug transporters and metabolizing enzymes in the disposition and drug interactions of dolutegravir, a HIV integrase inhibitor. Reese MJ; Savina PM; Generaux GT; Tracey H; Humphreys JE; Kanaoka E; Webster LO; Harmon KA; Clarke JD; Polli JW Drug Metab Dispos; 2013 Feb; 41(2):353-61. PubMed ID: 23132334 [TBL] [Abstract][Full Text] [Related]
17. Upcyte Human Hepatocytes: a Potent In Vitro Tool for the Prediction of Hepatic Clearance of Metabolically Stable Compounds. Schaefer M; Schänzle G; Bischoff D; Süssmuth RD Drug Metab Dispos; 2016 Mar; 44(3):435-44. PubMed ID: 26712819 [TBL] [Abstract][Full Text] [Related]
18. Down-regulation of organic anion transporter expression in human hepatocytes exposed to the proinflammatory cytokine interleukin 1beta. Le Vee M; Gripon P; Stieger B; Fardel O Drug Metab Dispos; 2008 Feb; 36(2):217-22. PubMed ID: 17991769 [TBL] [Abstract][Full Text] [Related]
19. HepaRG cells as an in vitro model for evaluation of cytochrome P450 induction in humans. Kanebratt KP; Andersson TB Drug Metab Dispos; 2008 Jan; 36(1):137-45. PubMed ID: 17954527 [TBL] [Abstract][Full Text] [Related]
20. Comparison of Liver Cell Models Using the Basel Phenotyping Cocktail. Berger B; Donzelli M; Maseneni S; Boess F; Roth A; Krähenbühl S; Haschke M Front Pharmacol; 2016; 7():443. PubMed ID: 27917125 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]