BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

68 related articles for article (PubMed ID: 25490442)

  • 1. DOTting the path to doom: how acceleration of histone methylation leads to leukemia.
    Bach C; Slany RK
    Cancer Cell; 2014 Dec; 26(6):781-782. PubMed ID: 25490442
    [TBL] [Abstract][Full Text] [Related]  

  • 2. AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes.
    Deshpande AJ; Deshpande A; Sinha AU; Chen L; Chang J; Cihan A; Fazio M; Chen CW; Zhu N; Koche R; Dzhekieva L; Ibáñez G; Dias S; Banka D; Krivtsov A; Luo M; Roeder RG; Bradner JE; Bernt KM; Armstrong SA
    Cancer Cell; 2014 Dec; 26(6):896-908. PubMed ID: 25464900
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Epigenetics: Histone methylation: it's in the numbers.
    Alderton GK
    Nat Rev Cancer; 2015 Jan; 15(1):1. PubMed ID: 25533665
    [No Abstract]   [Full Text] [Related]  

  • 4. Global reduction of the epigenetic H3K79 methylation mark and increased chromosomal instability in CALM-AF10-positive leukemias.
    Lin YH; Kakadia PM; Chen Y; Li YQ; Deshpande AJ; Buske C; Zhang KL; Zhang Y; Xu GL; Bohlander SK
    Blood; 2009 Jul; 114(3):651-8. PubMed ID: 19443658
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79.
    Chen S; Yang Z; Wilkinson AW; Deshpande AJ; Sidoli S; Krajewski K; Strahl BD; Garcia BA; Armstrong SA; Patel DJ; Gozani O
    Mol Cell; 2015 Oct; 60(2):319-27. PubMed ID: 26439302
    [TBL] [Abstract][Full Text] [Related]  

  • 6. H3K79 methylation profiles define murine and human MLL-AF4 leukemias.
    Krivtsov AV; Feng Z; Lemieux ME; Faber J; Vempati S; Sinha AU; Xia X; Jesneck J; Bracken AP; Silverman LB; Kutok JL; Kung AL; Armstrong SA
    Cancer Cell; 2008 Nov; 14(5):355-68. PubMed ID: 18977325
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inactivation of PBX3 and HOXA9 by down-regulating H3K79 methylation represses NPM1-mutated leukemic cell survival.
    Zhang W; Zhao C; Zhao J; Zhu Y; Weng X; Chen Q; Sun H; Mi JQ; Li J; Zhu J; Chen Z; Pandolfi PP; Chen S; Yan X; Xu J
    Theranostics; 2018; 8(16):4359-4371. PubMed ID: 30214626
    [TBL] [Abstract][Full Text] [Related]  

  • 8. DOT1L interaction partner AF10 controls patterning of H3K79 methylation and RNA polymerase II to maintain cell identity.
    Wille CK; Neumann EN; Deshpande AJ; Sridharan R
    Stem Cell Reports; 2023 Dec; 18(12):2451-2463. PubMed ID: 37995701
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia.
    Stein EM; Garcia-Manero G; Rizzieri DA; Tibes R; Berdeja JG; Savona MR; Jongen-Lavrenic M; Altman JK; Thomson B; Blakemore SJ; Daigle SR; Waters NJ; Suttle AB; Clawson A; Pollock R; Krivtsov A; Armstrong SA; DiMartino J; Hedrick E; Löwenberg B; Tallman MS
    Blood; 2018 Jun; 131(24):2661-2669. PubMed ID: 29724899
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structural characteristics of coiled-coil regions in AF10-DOT1L and AF10-inhibitory peptide complex.
    Zhou Z; Kang S; Huang Z; Zhou Z; Chen S
    J Leukoc Biol; 2021 Dec; 110(6):1091-1099. PubMed ID: 33993518
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Regulation of Wnt signaling target gene expression by the histone methyltransferase DOT1L.
    Gibbons GS; Owens SR; Fearon ER; Nikolovska-Coleska Z
    ACS Chem Biol; 2015 Jan; 10(1):109-14. PubMed ID: 25361163
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Dot1L mediated histone H3 lysine79 methylation is essential to meiosis progression in mouse oocytes.
    Wang X; Gao W; Ma X; Wang X; Song C; Huang X; Liu H
    Neuro Endocrinol Lett; 2014; 35(6):523-30. PubMed ID: 25433842
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis.
    Zhang H; Zhou B; Qin S; Xu J; Harding R; Tempel W; Nayak V; Li Y; Loppnau P; Dou Y; Min J
    Genes Dev; 2018 Mar; 32(5-6):341-346. PubMed ID: 29563185
    [TBL] [Abstract][Full Text] [Related]  

  • 14. NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis.
    Wang GG; Cai L; Pasillas MP; Kamps MP
    Nat Cell Biol; 2007 Jul; 9(7):804-12. PubMed ID: 17589499
    [TBL] [Abstract][Full Text] [Related]  

  • 15. DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.
    Chen CW; Koche RP; Sinha AU; Deshpande AJ; Zhu N; Eng R; Doench JG; Xu H; Chu SH; Qi J; Wang X; Delaney C; Bernt KM; Root DE; Hahn WC; Bradner JE; Armstrong SA
    Nat Med; 2015 Apr; 21(4):335-43. PubMed ID: 25822366
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Reconstructing the disease model and epigenetic networks for MLL-AF4 leukemia.
    Zeisig BB; Cheung N; Yeung J; So CW
    Cancer Cell; 2008 Nov; 14(5):345-7. PubMed ID: 18977321
    [TBL] [Abstract][Full Text] [Related]  

  • 17. AF10 (MLLT10) prevents somatic cell reprogramming through regulation of DOT1L-mediated H3K79 methylation.
    Uğurlu-Çimen D; Odluyurt D; Sevinç K; Özkan-Küçük NE; Özçimen B; Demirtaş D; Enüstün E; Aztekin C; Philpott M; Oppermann U; Özlü N; Önder TT
    Epigenetics Chromatin; 2021 Jul; 14(1):32. PubMed ID: 34215314
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The role of the PZP domain of AF10 in acute leukemia driven by AF10 translocations.
    Klein BJ; Deshpande A; Cox KL; Xuan F; Zandian M; Barbosa K; Khanal S; Tong Q; Zhang Y; Zhang P; Sinha A; Bohlander SK; Shi X; Wen H; Poirier MG; Deshpande AJ; Kutateladze TG
    Nat Commun; 2021 Jul; 12(1):4130. PubMed ID: 34226546
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom).
    Mohan M; Herz HM; Takahashi YH; Lin C; Lai KC; Zhang Y; Washburn MP; Florens L; Shilatifard A
    Genes Dev; 2010 Mar; 24(6):574-89. PubMed ID: 20203130
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Leukaemic transformation by CALM-AF10 involves upregulation of Hoxa5 by hDOT1L.
    Okada Y; Jiang Q; Lemieux M; Jeannotte L; Su L; Zhang Y
    Nat Cell Biol; 2006 Sep; 8(9):1017-24. PubMed ID: 16921363
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 4.