115 related articles for article (PubMed ID: 25499883)
1. Novel heterocyclic scaffolds of GW4064 as farnesoid X receptor agonists.
Smalley TL; Boggs S; Caravella JA; Chen L; Creech KL; Deaton DN; Kaldor I; Parks DJ
Bioorg Med Chem Lett; 2015 Jan; 25(2):280-4. PubMed ID: 25499883
[TBL] [Abstract][Full Text] [Related]
2. Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064.
Bass JY; Caldwell RD; Caravella JA; Chen L; Creech KL; Deaton DN; Madauss KP; Marr HB; McFadyen RB; Miller AB; Parks DJ; Todd D; Williams SP; Wisely GB
Bioorg Med Chem Lett; 2009 Jun; 19(11):2969-73. PubMed ID: 19410460
[TBL] [Abstract][Full Text] [Related]
3. Fragmentation of GW4064 led to a highly potent partial farnesoid X receptor agonist with improved drug-like properties.
Flesch D; Gabler M; Lill A; Gomez RC; Steri R; Schneider G; Stark H; Schubert-Zsilavecz M; Merk D
Bioorg Med Chem; 2015 Jul; 23(13):3490-8. PubMed ID: 25934227
[TBL] [Abstract][Full Text] [Related]
4. A formulation-enabled preclinical efficacy assessment of a farnesoid X receptor agonist, GW4064, in hamsters and cynomolgus monkeys.
Chiang PC; Thompson DC; Ghosh S; Heitmeier MR
J Pharm Sci; 2011 Nov; 100(11):4722-33. PubMed ID: 21660973
[TBL] [Abstract][Full Text] [Related]
5. Novel substituted isoxazole FXR agonists with cyclopropyl, hydroxycyclobutyl and hydroxyazetidinyl linkers: Understanding and improving key determinants of pharmacological properties.
Kinzel O; Steeneck C; Schlüter T; Schulz A; Gege C; Hahn U; Hambruch E; Hornberger M; Spalwisz A; Frick K; Perović-Ottstadt S; Deuschle U; Burnet M; Kremoser C
Bioorg Med Chem Lett; 2016 Aug; 26(15):3746-53. PubMed ID: 27268696
[TBL] [Abstract][Full Text] [Related]
6. Synthesis of Novel Farnesoid X Receptor Agonists and Validation of Their Efficacy in Activating Differentiation of Mouse Bone Marrow-Derived Mesenchymal Stem Cells into Osteoblasts.
Fujimori K; Iguchi Y; Yamashita Y; Gohda K; Teno N
Molecules; 2019 Nov; 24(22):. PubMed ID: 31744088
[TBL] [Abstract][Full Text] [Related]
7. Knocking on FXR's door: the "hammerhead"-structure series of FXR agonists - amphiphilic isoxazoles with potent in vitro and in vivo activities.
Gege C; Kinzel O; Steeneck C; Schulz A; Kremoser C
Curr Top Med Chem; 2014; 14(19):2143-58. PubMed ID: 25388536
[TBL] [Abstract][Full Text] [Related]
8. Development of time resolved fluorescence resonance energy transfer-based assay for FXR antagonist discovery.
Yu DD; Lin W; Chen T; Forman BM
Bioorg Med Chem; 2013 Jul; 21(14):4266-78. PubMed ID: 23688559
[TBL] [Abstract][Full Text] [Related]
9. Unbinding pathways of GW4064 from human farnesoid X receptor as revealed by molecular dynamics simulations.
Li W; Fu J; Cheng F; Zheng M; Zhang J; Liu G; Tang Y
J Chem Inf Model; 2012 Nov; 52(11):3043-52. PubMed ID: 23101941
[TBL] [Abstract][Full Text] [Related]
10. Farnesoid X receptor agonist GW4064 indirectly inhibits HCV entry into cells via down-regulating scavenger receptor class B type I.
Wu ZY; Li H; Li JR; Lv XQ; Jiang JD; Peng ZG
Eur J Pharmacol; 2019 Jun; 853():111-120. PubMed ID: 30902657
[TBL] [Abstract][Full Text] [Related]
11. Conformationally constrained farnesoid X receptor (FXR) agonists: alternative replacements of the stilbene.
Akwabi-Ameyaw A; Caravella JA; Chen L; Creech KL; Deaton DN; Madauss KP; Marr HB; Miller AB; Navas F; Parks DJ; Spearing PK; Todd D; Williams SP; Wisely GB
Bioorg Med Chem Lett; 2011 Oct; 21(20):6154-60. PubMed ID: 21890356
[TBL] [Abstract][Full Text] [Related]
12. Structure-guided modification of isoxazole-type FXR agonists: Identification of a potent and orally bioavailable FXR modulator.
Luo G; Lin X; Li Z; Xiao M; Li X; Zhang D; Xiang H
Eur J Med Chem; 2021 Jan; 209():112910. PubMed ID: 33049605
[TBL] [Abstract][Full Text] [Related]
13. Farnesoid X receptor agonists attenuate colonic epithelial secretory function and prevent experimental diarrhoea in vivo.
Mroz MS; Keating N; Ward JB; Sarker R; Amu S; Aviello G; Donowitz M; Fallon PG; Keely SJ
Gut; 2014 May; 63(5):808-17. PubMed ID: 23916961
[TBL] [Abstract][Full Text] [Related]
14. Farnesoid X Receptor Agonist GW4064 Inhibits Aromatase and ERβ Expression in Human Endometriotic Stromal Cells.
Wu PL; Zeng C; Zhou YF; Yin L; Yu XL; Xue Q
Reprod Sci; 2019 Aug; 26(8):1111-1120. PubMed ID: 30428773
[TBL] [Abstract][Full Text] [Related]
15. [Effects of farnesoid X receptor agonist on adiponectin and its receptors].
Xin X; Zhong M; Zhang S; Peng Y; Zhu W; Zhang Y
Nan Fang Yi Ke Da Xue Xue Bao; 2014 Jan; 34(1):109-12. PubMed ID: 24463129
[TBL] [Abstract][Full Text] [Related]
16. FXR agonist activity of conformationally constrained analogs of GW 4064.
Akwabi-Ameyaw A; Bass JY; Caldwell RD; Caravella JA; Chen L; Creech KL; Deaton DN; Madauss KP; Marr HB; McFadyen RB; Miller AB; Navas F; Parks DJ; Spearing PK; Todd D; Williams SP; Bruce Wisely G
Bioorg Med Chem Lett; 2009 Aug; 19(16):4733-9. PubMed ID: 19586769
[TBL] [Abstract][Full Text] [Related]
17. Knockdown of ATP8B1 expression leads to specific downregulation of the bile acid sensor FXR in HepG2 cells: effect of the FXR agonist GW4064.
Martínez-Fernández P; Hierro L; Jara P; Alvarez L
Am J Physiol Gastrointest Liver Physiol; 2009 May; 296(5):G1119-29. PubMed ID: 19228886
[TBL] [Abstract][Full Text] [Related]
18. Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064.
Akwabi-Ameyaw A; Bass JY; Caldwell RD; Caravella JA; Chen L; Creech KL; Deaton DN; Jones SA; Kaldor I; Liu Y; Madauss KP; Marr HB; McFadyen RB; Miller AB; Navas F; Parks DJ; Spearing PK; Todd D; Williams SP; Wisely GB
Bioorg Med Chem Lett; 2008 Aug; 18(15):4339-43. PubMed ID: 18621523
[TBL] [Abstract][Full Text] [Related]
19. Identification of an N-oxide pyridine GW4064 analog as a potent FXR agonist.
Feng S; Yang M; Zhang Z; Wang Z; Hong D; Richter H; Benson GM; Bleicher K; Grether U; Martin RE; Plancher JM; Kuhn B; Rudolph MG; Chen L
Bioorg Med Chem Lett; 2009 May; 19(9):2595-8. PubMed ID: 19328688
[TBL] [Abstract][Full Text] [Related]
20. Conformationally constrained farnesoid X receptor (FXR) agonists: heteroaryl replacements of the naphthalene.
Bass JY; Caravella JA; Chen L; Creech KL; Deaton DN; Madauss KP; Marr HB; McFadyen RB; Miller AB; Mills WY; Navas F; Parks DJ; Smalley TL; Spearing PK; Todd D; Williams SP; Wisely GB
Bioorg Med Chem Lett; 2011 Feb; 21(4):1206-13. PubMed ID: 21256005
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]