These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
268 related articles for article (PubMed ID: 25501576)
1. Phase I dose-escalation trial of the oral investigational Hedgehog signaling pathway inhibitor TAK-441 in patients with advanced solid tumors. Goldman J; Eckhardt SG; Borad MJ; Curtis KK; Hidalgo M; Calvo E; Ryan DP; Wirth LJ; Parikh A; Partyka J; Faessel H; Gangolli E; Stewart S; Rosen LS; Bowles DW Clin Cancer Res; 2015 Mar; 21(5):1002-9. PubMed ID: 25501576 [TBL] [Abstract][Full Text] [Related]
2. A phase I, multicenter, open-label, first-in-human, dose-escalation study of the oral smoothened inhibitor Sonidegib (LDE225) in patients with advanced solid tumors. Rodon J; Tawbi HA; Thomas AL; Stoller RG; Turtschi CP; Baselga J; Sarantopoulos J; Mahalingam D; Shou Y; Moles MA; Yang L; Granvil C; Hurh E; Rose KL; Amakye DD; Dummer R; Mita AC Clin Cancer Res; 2014 Apr; 20(7):1900-9. PubMed ID: 24523439 [TBL] [Abstract][Full Text] [Related]
3. A phase I study of PF-04449913, an oral hedgehog inhibitor, in patients with advanced solid tumors. Wagner AJ; Messersmith WA; Shaik MN; Li S; Zheng X; McLachlan KR; Cesari R; Courtney R; Levin WJ; El-Khoueiry AB Clin Cancer Res; 2015 Mar; 21(5):1044-51. PubMed ID: 25388167 [TBL] [Abstract][Full Text] [Related]
4. Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors. LoRusso PM; Rudin CM; Reddy JC; Tibes R; Weiss GJ; Borad MJ; Hann CL; Brahmer JR; Chang I; Darbonne WC; Graham RA; Zerivitz KL; Low JA; Von Hoff DD Clin Cancer Res; 2011 Apr; 17(8):2502-11. PubMed ID: 21300762 [TBL] [Abstract][Full Text] [Related]
5. Pharmacokinetic and pharmacodynamic modeling of hedgehog inhibitor TAK-441 for the inhibition of Gli1 messenger RNA expression and antitumor efficacy in xenografted tumor model mice. Kogame A; Tagawa Y; Shibata S; Tojo H; Miyamoto M; Tohyama K; Kondo T; Prakash S; Shyu WC; Asahi S Drug Metab Dispos; 2013 Apr; 41(4):727-34. PubMed ID: 23298863 [TBL] [Abstract][Full Text] [Related]
6. A First-in-Human, Phase I, Dose-Escalation Study of TAK-117, a Selective PI3Kα Isoform Inhibitor, in Patients with Advanced Solid Malignancies. Juric D; de Bono JS; LoRusso PM; Nemunaitis J; Heath EI; Kwak EL; Macarulla Mercadé T; Geuna E; Jose de Miguel-Luken M; Patel C; Kuida K; Sankoh S; Westin EH; Zohren F; Shou Y; Tabernero J Clin Cancer Res; 2017 Sep; 23(17):5015-5023. PubMed ID: 28490463 [No Abstract] [Full Text] [Related]
7. A phase I dose-escalation study of TAK-733, an investigational oral MEK inhibitor, in patients with advanced solid tumors. Adjei AA; LoRusso P; Ribas A; Sosman JA; Pavlick A; Dy GK; Zhou X; Gangolli E; Kneissl M; Faucette S; Neuwirth R; Bózon V Invest New Drugs; 2017 Feb; 35(1):47-58. PubMed ID: 27650277 [TBL] [Abstract][Full Text] [Related]
8. Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. Von Hoff DD; LoRusso PM; Rudin CM; Reddy JC; Yauch RL; Tibes R; Weiss GJ; Borad MJ; Hann CL; Brahmer JR; Mackey HM; Lum BL; Darbonne WC; Marsters JC; de Sauvage FJ; Low JA N Engl J Med; 2009 Sep; 361(12):1164-72. PubMed ID: 19726763 [TBL] [Abstract][Full Text] [Related]
9. Phase I safety, pharmacokinetic, and pharmacodynamic study of SAR245408 (XL147), an oral pan-class I PI3K inhibitor, in patients with advanced solid tumors. Shapiro GI; Rodon J; Bedell C; Kwak EL; Baselga J; Braña I; Pandya SS; Scheffold C; Laird AD; Nguyen LT; Xu Y; Egile C; Edelman G Clin Cancer Res; 2014 Jan; 20(1):233-45. PubMed ID: 24166903 [TBL] [Abstract][Full Text] [Related]
10. A First-in-Human Phase 1 Study of LY3023414, an Oral PI3K/mTOR Dual Inhibitor, in Patients with Advanced Cancer. Bendell JC; Varghese AM; Hyman DM; Bauer TM; Pant S; Callies S; Lin J; Martinez R; Wickremsinhe E; Fink A; Wacheck V; Moore KN Clin Cancer Res; 2018 Jul; 24(14):3253-3262. PubMed ID: 29636360 [No Abstract] [Full Text] [Related]
11. Phase I, dose-escalation trial of the oral cyclin-dependent kinase 4/6 inhibitor PD 0332991, administered using a 21-day schedule in patients with advanced cancer. Flaherty KT; Lorusso PM; Demichele A; Abramson VG; Courtney R; Randolph SS; Shaik MN; Wilner KD; O'Dwyer PJ; Schwartz GK Clin Cancer Res; 2012 Jan; 18(2):568-76. PubMed ID: 22090362 [TBL] [Abstract][Full Text] [Related]
12. Frequent dose interruptions are required for patients receiving oral kinase inhibitor therapy for advanced renal cell carcinoma. La Vine DB; Coleman TA; Davis CH; Carbonell CE; Davis WB Am J Clin Oncol; 2010 Jun; 33(3):217-20. PubMed ID: 19745694 [TBL] [Abstract][Full Text] [Related]
13. Phase I safety, pharmacokinetic, and pharmacodynamic study of SAR245409 (XL765), a novel, orally administered PI3K/mTOR inhibitor in patients with advanced solid tumors. Papadopoulos KP; Tabernero J; Markman B; Patnaik A; Tolcher AW; Baselga J; Shi W; Egile C; Ruiz-Soto R; Laird AD; Miles D; Lorusso PM Clin Cancer Res; 2014 May; 20(9):2445-56. PubMed ID: 24583798 [TBL] [Abstract][Full Text] [Related]
14. Phase 1 dose-escalation, pharmacokinetic, and cerebrospinal fluid distribution study of TAK-285, an investigational inhibitor of EGFR and HER2. LoRusso P; Venkatakrishnan K; Chiorean EG; Noe D; Wu JT; Sankoh S; Corvez M; Sausville EA Invest New Drugs; 2014 Feb; 32(1):160-70. PubMed ID: 23817974 [TBL] [Abstract][Full Text] [Related]
15. A Phase I dose-escalation, pharmacokinetics and food-effect study of oral donafenib in patients with advanced solid tumours. Li X; Qiu M; Wang S; Zhu H; Feng B; Zheng L Cancer Chemother Pharmacol; 2020 Mar; 85(3):593-604. PubMed ID: 32008115 [TBL] [Abstract][Full Text] [Related]
16. Expanded access study of patients with advanced basal cell carcinoma treated with the Hedgehog pathway inhibitor, vismodegib. Chang AL; Solomon JA; Hainsworth JD; Goldberg L; McKenna E; Day BM; Chen DM; Weiss GJ J Am Acad Dermatol; 2014 Jan; 70(1):60-9. PubMed ID: 24189279 [TBL] [Abstract][Full Text] [Related]
17. Phase I Study of LY2940680, a Smo Antagonist, in Patients with Advanced Cancer Including Treatment-Naïve and Previously Treated Basal Cell Carcinoma. Bendell J; Andre V; Ho A; Kudchadkar R; Migden M; Infante J; Tiu RV; Pitou C; Tucker T; Brail L; Von Hoff D Clin Cancer Res; 2018 May; 24(9):2082-2091. PubMed ID: 29483143 [No Abstract] [Full Text] [Related]
18. Phase I study of aurora A kinase inhibitor MLN8237 in advanced solid tumors: safety, pharmacokinetics, pharmacodynamics, and bioavailability of two oral formulations. Dees EC; Cohen RB; von Mehren M; Stinchcombe TE; Liu H; Venkatakrishnan K; Manfredi M; Fingert H; Burris HA; Infante JR Clin Cancer Res; 2012 Sep; 18(17):4775-84. PubMed ID: 22767670 [TBL] [Abstract][Full Text] [Related]
19. Phase I first-in-human study of CUDC-101, a multitargeted inhibitor of HDACs, EGFR, and HER2 in patients with advanced solid tumors. Shimizu T; LoRusso PM; Papadopoulos KP; Patnaik A; Beeram M; Smith LS; Rasco DW; Mays TA; Chambers G; Ma A; Wang J; Laliberte R; Voi M; Tolcher AW Clin Cancer Res; 2014 Oct; 20(19):5032-40. PubMed ID: 25107918 [TBL] [Abstract][Full Text] [Related]
20. Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: modification of the core skeleton for improved solubility. Ohashi T; Oguro Y; Tanaka T; Shiokawa Z; Tanaka Y; Shibata S; Sato Y; Yamakawa H; Hattori H; Yamamoto Y; Kondo S; Miyamoto M; Nishihara M; Ishimura Y; Tojo H; Baba A; Sasaki S Bioorg Med Chem; 2012 Sep; 20(18):5507-17. PubMed ID: 22898254 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]