BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

83 related articles for article (PubMed ID: 25505563)

  • 1. Enantioselectivity in the cytochrome P450-dependent conversion of tegafur to 5-fluorouracil in human liver microsomes.
    Yamamiya I; Yoshisue K; Ishii Y; Yamada H; Yoshida K
    Pharmacol Res Perspect; 2013 Oct; 1(1):e00009. PubMed ID: 25505563
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Bioactivation of tegafur to 5-fluorouracil is catalyzed by cytochrome P-450 2A6 in human liver microsomes in vitro.
    Ikeda K; Yoshisue K; Matsushima E; Nagayama S; Kobayashi K; Tyson CA; Chiba K; Kawaguchi Y
    Clin Cancer Res; 2000 Nov; 6(11):4409-15. PubMed ID: 11106261
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes.
    Komatsu T; Yamazaki H; Shimada N; Nakajima M; Yokoi T
    Drug Metab Dispos; 2000 Dec; 28(12):1457-63. PubMed ID: 11095583
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Effect of CYP2A6 genetic polymorphism on the metabolic conversion of tegafur to 5-fluorouracil and its enantioselectivity.
    Yamamiya I; Yoshisue K; Ishii Y; Yamada H; Chiba M
    Drug Metab Dispos; 2014 Sep; 42(9):1485-92. PubMed ID: 25002745
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Species variation in the enantioselective metabolism of tegafur to 5-fluorouracil among rats, dogs and monkeys.
    Yamamiya I; Yoshisue K; Ishii Y; Yamada H; Yoshida K
    J Pharm Pharmacol; 2014 Dec; 66(12):1686-97. PubMed ID: 25117829
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Formation pathways of gamma-butyrolactone from the furan ring of tegafur during its conversion to 5-fluorouracil.
    Yamamiya I; Yoshisue K; Matsushima E; Nagayama S
    Drug Metab Dispos; 2010 Aug; 38(8):1267-76. PubMed ID: 20463005
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The contribution of cytochrome P450 to the metabolism of tegafur in human liver.
    Kajita J; Fuse E; Kuwabara T; Kobayashi H
    Drug Metab Pharmacokinet; 2003; 18(5):303-9. PubMed ID: 15618749
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Involvement of microsomal cytochrome P450 and cytosolic thymidine phosphorylase in 5-fluorouracil formation from tegafur in human liver.
    Komatsu T; Yamazaki H; Shimada N; Nagayama S; Kawaguchi Y; Nakajima M; Yokoi T
    Clin Cancer Res; 2001 Mar; 7(3):675-81. PubMed ID: 11297264
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Cytosolic and microsomal activation of doxifluridine and tegafur to produce 5-fluorouracil in human liver.
    Ozawa S; Hamada M; Murayama N; Nakajima Y; Kaniwa N; Matsumoto Y; Fukuoka M; Sawada J; Ohno Y
    Cancer Chemother Pharmacol; 2002 Dec; 50(6):454-8. PubMed ID: 12451471
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Identification of human cytochrome P450 isoforms involved in the 3-hydroxylation of quinine by human live microsomes and nine recombinant human cytochromes P450.
    Zhao XJ; Yokoyama H; Chiba K; Wanwimolruk S; Ishizaki T
    J Pharmacol Exp Ther; 1996 Dec; 279(3):1327-34. PubMed ID: 8968357
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Human reductive halothane metabolism in vitro is catalyzed by cytochrome P450 2A6 and 3A4.
    Spracklin DK; Thummel KE; Kharasch ED
    Drug Metab Dispos; 1996 Sep; 24(9):976-83. PubMed ID: 8886607
    [TBL] [Abstract][Full Text] [Related]  

  • 12. CYP2A6 AND CYP2B6 are involved in nornicotine formation from nicotine in humans: interindividual differences in these contributions.
    Yamanaka H; Nakajima M; Fukami T; Sakai H; Nakamura A; Katoh M; Takamiya M; Aoki Y; Yokoi T
    Drug Metab Dispos; 2005 Dec; 33(12):1811-8. PubMed ID: 16135656
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Expression of CYP2A6 in tumor cells augments cellular sensitivity to tegafur.
    Murayama N; Sai K; Nakajima Y; Kaniwa N; Ozawa S; Ohno Y; Sawada J
    Jpn J Cancer Res; 2001 May; 92(5):524-8. PubMed ID: 11376561
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Human cytochrome P450 isozymes in metabolism and health effects of gasoline ethers.
    Hong JY; Wang YY; Mohr SN; Bondoc FY; Deng C
    Res Rep Health Eff Inst; 2001 May; (102):7-27; discussion 95-109. PubMed ID: 11504148
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Stereoselective metabolism and pharmacokinetics of tegafur.
    Damle BD; Narasimhan NI; Kaul S
    Biopharm Drug Dispos; 2001 Mar; 22(2):45-52. PubMed ID: 11745907
    [TBL] [Abstract][Full Text] [Related]  

  • 16. (+)-cis-3,5-dimethyl-2-(3-pyridyl) thiazolidin-4-one hydrochloride (SM-12502) as a novel substrate for cytochrome P450 2A6 in human liver microsomes.
    Nunoya K; Yokoi Y; Kimura K; Kodama T; Funayama M; Inoue K; Nagashima K; Funae Y; Shimada N; Green C; Kamataki T
    J Pharmacol Exp Ther; 1996 May; 277(2):768-74. PubMed ID: 8627557
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Cytochrome P450 2E1 is the principal catalyst of human oxidative halothane metabolism in vitro.
    Spracklin DK; Hankins DC; Fisher JM; Thummel KE; Kharasch ED
    J Pharmacol Exp Ther; 1997 Apr; 281(1):400-11. PubMed ID: 9103523
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Association analysis of CYP2A6 genotypes and haplotypes with 5-fluorouracil formation from tegafur in human liver microsomes.
    Wang H; Bian T; Liu D; Jin T; Chen Y; Lin A; Chen C
    Pharmacogenomics; 2011 Apr; 12(4):481-92. PubMed ID: 21521021
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Contribution of CYP2C9, CYP2A6, and CYP2B6 to valproic acid metabolism in hepatic microsomes from individuals with the CYP2C9*1/*1 genotype.
    Kiang TK; Ho PC; Anari MR; Tong V; Abbott FS; Chang TK
    Toxicol Sci; 2006 Dec; 94(2):261-71. PubMed ID: 16945988
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Identification of human cytochrome P-450 isoforms involved in metabolism of R(+)- and S(-)-gallopamil: utility of in vitro disappearance rate.
    Suzuki A; Iida I; Tanaka F; Akimoto M; Fukushima K; Tani M; Ishizaki T; Chiba K
    Drug Metab Dispos; 1999 Nov; 27(11):1254-9. PubMed ID: 10534309
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.