339 related articles for article (PubMed ID: 25516597)
1. Structurally similar allosteric modulators of α7 nicotinic acetylcholine receptors exhibit five distinct pharmacological effects.
Gill-Thind JK; Dhankher P; D'Oyley JM; Sheppard TD; Millar NS
J Biol Chem; 2015 Feb; 290(6):3552-62. PubMed ID: 25516597
[TBL] [Abstract][Full Text] [Related]
2. A series of α7 nicotinic acetylcholine receptor allosteric modulators with close chemical similarity but diverse pharmacological properties.
Gill JK; Dhankher P; Sheppard TD; Sher E; Millar NS
Mol Pharmacol; 2012 May; 81(5):710-8. PubMed ID: 22328718
[TBL] [Abstract][Full Text] [Related]
3. Allosteric Agonism of
Gulsevin A; Papke RL; Stokes C; Garai S; Thakur GA; Quadri M; Horenstein NA
Mol Pharmacol; 2019 Jun; 95(6):606-614. PubMed ID: 30944209
[TBL] [Abstract][Full Text] [Related]
4. Critical Molecular Determinants of α7 Nicotinic Acetylcholine Receptor Allosteric Activation: SEPARATION OF DIRECT ALLOSTERIC ACTIVATION AND POSITIVE ALLOSTERIC MODULATION.
Horenstein NA; Papke RL; Kulkarni AR; Chaturbhuj GU; Stokes C; Manther K; Thakur GA
J Biol Chem; 2016 Mar; 291(10):5049-67. PubMed ID: 26742843
[TBL] [Abstract][Full Text] [Related]
5. Identification by virtual screening and functional characterisation of novel positive and negative allosteric modulators of the α7 nicotinic acetylcholine receptor.
Smelt CLC; Sanders VR; Newcombe J; Burt RP; Sheppard TD; Topf M; Millar NS
Neuropharmacology; 2018 Sep; 139():194-204. PubMed ID: 30009834
[TBL] [Abstract][Full Text] [Related]
6. Molecular interactions of type I and type II positive allosteric modulators with the human α7 nicotinic acetylcholine receptor: an in silico study.
Targowska-Duda KM; Kaczor AA; Jozwiak K; Arias HR
J Biomol Struct Dyn; 2019 Feb; 37(2):411-439. PubMed ID: 29363414
[TBL] [Abstract][Full Text] [Related]
7. The activity of GAT107, an allosteric activator and positive modulator of α7 nicotinic acetylcholine receptors (nAChR), is regulated by aromatic amino acids that span the subunit interface.
Papke RL; Horenstein NA; Kulkarni AR; Stokes C; Corrie LW; Maeng CY; Thakur GA
J Biol Chem; 2014 Feb; 289(7):4515-31. PubMed ID: 24362025
[TBL] [Abstract][Full Text] [Related]
8. Molecular modelling studies on ɑ7 nicotinic receptor allosteric modulators yields novel filter-based virtual screening protocol.
Al Rawashdah S; Hamrouni A; Sadek B; Amer R; Metwaly M; Atatreh N; Ghattas MA
J Mol Graph Model; 2019 Nov; 92():44-54. PubMed ID: 31306865
[TBL] [Abstract][Full Text] [Related]
9. Allosteric modulation of nicotinic acetylcholine receptors.
Chatzidaki A; Millar NS
Biochem Pharmacol; 2015 Oct; 97(4):408-417. PubMed ID: 26231943
[TBL] [Abstract][Full Text] [Related]
10. Agonist activation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site.
Gill JK; Savolainen M; Young GT; Zwart R; Sher E; Millar NS
Proc Natl Acad Sci U S A; 2011 Apr; 108(14):5867-72. PubMed ID: 21436053
[TBL] [Abstract][Full Text] [Related]
11. Diversity of Nicotinic Acetylcholine Receptor Positive Allosteric Modulators Revealed by Mutagenesis and a Revised Structural Model.
Newcombe J; Chatzidaki A; Sheppard TD; Topf M; Millar NS
Mol Pharmacol; 2018 Feb; 93(2):128-140. PubMed ID: 29196491
[TBL] [Abstract][Full Text] [Related]
12. Distinct profiles of alpha7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes.
Grønlien JH; Håkerud M; Ween H; Thorin-Hagene K; Briggs CA; Gopalakrishnan M; Malysz J
Mol Pharmacol; 2007 Sep; 72(3):715-24. PubMed ID: 17565004
[TBL] [Abstract][Full Text] [Related]
13. Differential Activation and Desensitization States Promoted by Noncanonical
Stokes C; Camacho-Hernandez GA; Thakur GA; Wu X; Taylor P; Papke RL
J Pharmacol Exp Ther; 2022 Nov; 383(2):157-171. PubMed ID: 36279397
[TBL] [Abstract][Full Text] [Related]
14. Activation of α7 nicotinic receptors by orthosteric and allosteric agonists: influence on single-channel kinetics and conductance.
Pałczyńska MM; Jindrichova M; Gibb AJ; Millar NS
Mol Pharmacol; 2012 Nov; 82(5):910-7. PubMed ID: 22874415
[TBL] [Abstract][Full Text] [Related]
15. Allosterically Potentiated
Miller DR; Khoshbouei H; Garai S; Cantwell LN; Stokes C; Thakur G; Papke RL
Mol Pharmacol; 2020 Dec; 98(6):695-709. PubMed ID: 33020143
[TBL] [Abstract][Full Text] [Related]
16. New quinoline derivatives as nicotinic receptor modulators.
Manetti D; Bellucci C; Dei S; Teodori E; Varani K; Spirova E; Kudryavtsev D; Shelukhina I; Tsetlin V; Romanelli MN
Eur J Med Chem; 2016 Mar; 110():246-58. PubMed ID: 26840365
[TBL] [Abstract][Full Text] [Related]
17. Differing Activity Profiles of the Stereoisomers of 2,3,5,6TMP-TQS, a Putative Silent Allosteric Modulator of
Papke RL; Garai S; Stokes C; Horenstein NA; Zimmerman AD; Abboud KA; Thakur GA
Mol Pharmacol; 2020 Oct; 98(4):292-302. PubMed ID: 32690627
[TBL] [Abstract][Full Text] [Related]
18. Potentiation and allosteric agonist activation of α7 nicotinic acetylcholine receptors: binding sites and hypotheses.
Sanders VR; Millar NS
Pharmacol Res; 2023 May; 191():106759. PubMed ID: 37023990
[TBL] [Abstract][Full Text] [Related]
19. Macroscopic and Microscopic Activation of
Quadri M; Garai S; Thakur GA; Stokes C; Gulsevin A; Horenstein NA; Papke RL
Mol Pharmacol; 2019 Jan; 95(1):43-61. PubMed ID: 30348894
[TBL] [Abstract][Full Text] [Related]
20. Competitive binding at a nicotinic receptor transmembrane site of two α7-selective positive allosteric modulators with differing effects on agonist-evoked desensitization.
Collins T; Young GT; Millar NS
Neuropharmacology; 2011 Dec; 61(8):1306-13. PubMed ID: 21820451
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
