BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

151 related articles for article (PubMed ID: 25527118)

  • 1. Pharmacokinetics of treosulfan and its active monoepoxide in pediatric patients after intravenous infusion of high-dose treosulfan prior to HSCT.
    Główka F; Kasprzyk A; Romański M; Wróbel T; Wachowiak J; Szpecht D; Kałwak K; Wiela-Hojeńska A; Dziatkiewicz P; Teżyk A; Żaba C
    Eur J Pharm Sci; 2015 Feb; 68():87-93. PubMed ID: 25527118
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Disposition of treosulfan and its active monoepoxide in a bone marrow, liver, lungs, brain, and muscle: Studies in a rat model with clinical relevance.
    Romański M; Kasprzyk A; Walczak M; Ziółkowska A; Główka F
    Eur J Pharm Sci; 2017 Nov; 109():616-623. PubMed ID: 28916482
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Relationship between exposure to treosulfan and its monoepoxytransformer - An insight from population pharmacokinetic study in pediatric patients before hematopoietic stem cell transplantation.
    Danielak D; Kasprzyk A; Wróbel T; Wachowiak J; Kałwak K; Główka F
    Eur J Pharm Sci; 2018 Jul; 120():1-9. PubMed ID: 29705215
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Rapid and sensitive liquid chromatography-tandem mass spectrometry method for determination of protein-free pro-drug treosulfan and its biologically active monoepoxy-transformer in plasma and brain tissue.
    Romański M; Teżyk A; Zaba C; Główka FK
    Talanta; 2014 Sep; 127():123-32. PubMed ID: 24913866
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Formation Rate-Limited Pharmacokinetics of Biologically Active Epoxy Transformers of Prodrug Treosulfan.
    Romański M; Kasprzyk A; Karbownik A; Szałek E; Główka FK
    J Pharm Sci; 2016 May; 105(5):1790-1797. PubMed ID: 27044946
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Penetration of Treosulfan and its Active Monoepoxide Transformation Product into Central Nervous System of Juvenile and Young Adult Rats.
    Romański M; Baumgart J; Böhm S; Główka FK
    Drug Metab Dispos; 2015 Dec; 43(12):1946-54. PubMed ID: 26428246
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Activation of Prodrug Treosulfan at pH 7.4 and 37°C Accompanied by Hydrolysis of Its Active Epoxides: Kinetic Studies with Clinical Relevance.
    Romański M; Urbaniak B; Kokot Z; Główka FK
    J Pharm Sci; 2015 Dec; 104(12):4433-4442. PubMed ID: 26422826
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Treosulfan Pharmacokinetics and its Variability in Pediatric and Adult Patients Undergoing Conditioning Prior to Hematopoietic Stem Cell Transplantation: Current State of the Art, In-Depth Analysis, and Perspectives.
    Romański M; Wachowiak J; Główka FK
    Clin Pharmacokinet; 2018 Oct; 57(10):1255-1265. PubMed ID: 29557088
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Determination of prodrug treosulfan and its biologically active monoepoxide in rat plasma, liver, lungs, kidneys, muscle, and brain by HPLC-ESI-MS/MS method.
    Romański M; Kasprzyk A; Teżyk A; Widerowska A; Żaba C; Główka F
    J Pharm Biomed Anal; 2017 Jun; 140():122-129. PubMed ID: 28346882
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Ocular disposition of treosulfan and its active epoxy-transformers following intravenous administration in rabbits.
    Romański M; Kasprzyk A; Karbownik A; Główka FK
    Drug Metab Pharmacokinet; 2016 Oct; 31(5):356-362. PubMed ID: 27662779
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Population pharmacokinetics of treosulfan and development of a limited sampling strategy in children prior to hematopoietic stem cell transplantation.
    Danielak D; Twardosz J; Kasprzyk A; Wachowiak J; Kałwak K; Główka F
    Eur J Clin Pharmacol; 2018 Jan; 74(1):79-89. PubMed ID: 28975382
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Determination of partition coefficients n-octanol/water for treosulfan and its epoxy-transformers: an example of a negative correlation between lipophilicity of unionized compounds and their retention in reversed-phase chromatography.
    Główka FK; Romański M; Siemiątkowska A
    J Chromatogr B Analyt Technol Biomed Life Sci; 2013 Apr; 923-924():92-7. PubMed ID: 23500352
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Effect of Temperature on the Kinetics of the Activation of Treosulfan and Hydrolytic Decomposition of Its Active Epoxy Derivatives.
    Romański M; Mikołajewski J; Główka FK
    J Pharm Sci; 2017 Oct; 106(10):3156-3160. PubMed ID: 28600186
    [TBL] [Abstract][Full Text] [Related]  

  • 14. HPLC method for determination of biologically active epoxy-transformers of treosulfan in human plasma: pharmacokinetic application.
    Główka FK; Romański M; Teżyk A; Zaba C; Wróbel T
    J Pharm Biomed Anal; 2012 Mar; 62():105-13. PubMed ID: 22260969
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Pharmacokinetics and Pharmacodynamics of Treosulfan in Patients With Thalassemia Major Undergoing Allogeneic Hematopoietic Stem Cell Transplantation.
    Mohanan E; Panetta JC; Lakshmi KM; Edison ES; Korula A; Na F; Abraham A; Viswabandya A; George B; Mathews V; Srivastava A; Balasubramanian P
    Clin Pharmacol Ther; 2018 Sep; 104(3):575-583. PubMed ID: 29247522
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Pharmacokinetics of high-dose i.v. treosulfan in children undergoing treosulfan-based preparative regimen for allogeneic haematopoietic SCT.
    Główka FK; Karaźniewicz-Łada M; Grund G; Wróbel T; Wachowiak J
    Bone Marrow Transplant; 2008 Oct; 42 Suppl 2():S67-70. PubMed ID: 18978748
    [TBL] [Abstract][Full Text] [Related]  

  • 17. High-dose treosulfan in conditioning prior to hematopoietic stem cell transplantation.
    Główka FK; Romański M; Wachowiak J
    Expert Opin Investig Drugs; 2010 Oct; 19(10):1275-95. PubMed ID: 20836619
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Direct high-performance liquid chromatography method with refractometric detection designed for stability studies of treosulfan and its biologically active epoxy-transformers.
    Główka FK; Romański M; Teżyk A; Żaba C
    J Pharm Biomed Anal; 2013 Jan; 72():145-9. PubMed ID: 23146239
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Clinical bioanalysis of treosulfan and its epoxides: The importance of collected blood processing for valid pharmacokinetic results.
    Romański M; Główka F
    J Pharm Biomed Anal; 2018 May; 153():199-203. PubMed ID: 29501039
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Treosulfan-thiotepa-fludarabine-based conditioning regimen for allogeneic transplantation in patients with thalassemia major: a single-center experience from north India.
    Choudhary D; Sharma SK; Gupta N; Kharya G; Pavecha P; Handoo A; Setia R; Katewa S
    Biol Blood Marrow Transplant; 2013 Mar; 19(3):492-5. PubMed ID: 23160007
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.