These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

394 related articles for article (PubMed ID: 25527701)

  • 1. What can crystal structures of aminergic receptors tell us about designing subtype-selective ligands?
    Michino M; Beuming T; Donthamsetti P; Newman AH; Javitch JA; Shi L
    Pharmacol Rev; 2015; 67(1):198-213. PubMed ID: 25527701
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A structural chemogenomics analysis of aminergic GPCRs: lessons for histamine receptor ligand design.
    Kooistra AJ; Kuhne S; de Esch IJ; Leurs R; de Graaf C
    Br J Pharmacol; 2013 Sep; 170(1):101-26. PubMed ID: 23713847
    [TBL] [Abstract][Full Text] [Related]  

  • 3. GPCRs through the keyhole: the role of protein flexibility in ligand binding to β-adrenoceptors.
    Emtage AL; Mistry SN; Fischer PM; Kellam B; Laughton CA
    J Biomol Struct Dyn; 2017 Sep; 35(12):2604-2619. PubMed ID: 27532213
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Rational Modification of the Biological Profile of GPCR Ligands through Combination with Other Biologically Active Moieties.
    Huang G; Nimczick M; Decker M
    Arch Pharm (Weinheim); 2015 Aug; 348(8):531-40. PubMed ID: 25941009
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Emerging opportunities for allosteric modulation of G-protein coupled receptors.
    Wang CI; Lewis RJ
    Biochem Pharmacol; 2013 Jan; 85(2):153-62. PubMed ID: 22975406
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structural basis for ligand binding and specificity in adrenergic receptors: implications for GPCR-targeted drug discovery.
    Huber T; Menon S; Sakmar TP
    Biochemistry; 2008 Oct; 47(42):11013-23. PubMed ID: 18821775
    [TBL] [Abstract][Full Text] [Related]  

  • 7. GPCR crystal structures: Medicinal chemistry in the pocket.
    Shonberg J; Kling RC; Gmeiner P; Löber S
    Bioorg Med Chem; 2015 Jul; 23(14):3880-906. PubMed ID: 25638496
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Molecular alliance-from orthosteric and allosteric ligands to dualsteric/bitopic agonists at G protein coupled receptors.
    Mohr K; Schmitz J; Schrage R; Tränkle C; Holzgrabe U
    Angew Chem Int Ed Engl; 2013 Jan; 52(2):508-16. PubMed ID: 23225228
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structure-Based Consensus Scoring Scheme for Selecting Class A Aminergic GPCR Fragments.
    Kelemen ÁA; Kiss R; Ferenczy GG; Kovács L; Flachner B; Lőrincz Z; Keserű GM
    J Chem Inf Model; 2016 Feb; 56(2):412-22. PubMed ID: 26760056
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs.
    McCorvy JD; Butler KV; Kelly B; Rechsteiner K; Karpiak J; Betz RM; Kormos BL; Shoichet BK; Dror RO; Jin J; Roth BL
    Nat Chem Biol; 2018 Feb; 14(2):126-134. PubMed ID: 29227473
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Template selection and refinement considerations for modelling aminergic GPCR-ligand complexes.
    Urmi KF; Finch AM; Griffith R
    J Mol Graph Model; 2017 Sep; 76():488-503. PubMed ID: 28818718
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Bridging the gap: bitopic ligands of G-protein-coupled receptors.
    Lane JR; Sexton PM; Christopoulos A
    Trends Pharmacol Sci; 2013 Jan; 34(1):59-66. PubMed ID: 23177916
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Three-dimensional descriptors for aminergic GPCRs: dependence on docking conformation and crystal structure.
    Jastrzębski S; Sieradzki I; Leśniak D; Tabor J; Bojarski AJ; Podlewska S
    Mol Divers; 2019 Aug; 23(3):603-613. PubMed ID: 30484023
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The future of G protein-coupled receptors as targets in drug discovery.
    Lundstrom K
    IDrugs; 2005 Nov; 8(11):909-13. PubMed ID: 16254784
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Addressing selective polypharmacology of antipsychotic drugs targeting the bioaminergic receptors through receptor dynamic conformational ensembles.
    Selvam B; Porter SL; Tikhonova IG
    J Chem Inf Model; 2013 Jul; 53(7):1761-74. PubMed ID: 23789628
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structural insights into ligand recognition and selectivity for classes A, B, and C GPCRs.
    Lee SM; Booe JM; Pioszak AA
    Eur J Pharmacol; 2015 Sep; 763(Pt B):196-205. PubMed ID: 25981303
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Intracellular Receptor Modulation: Novel Approach to Target GPCRs.
    Ortiz Zacarías NV; Lenselink EB; IJzerman AP; Handel TM; Heitman LH
    Trends Pharmacol Sci; 2018 Jun; 39(6):547-559. PubMed ID: 29653834
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Applying Structure-Based Drug Design Approaches to Allosteric Modulators of GPCRs.
    Congreve M; Oswald C; Marshall FH
    Trends Pharmacol Sci; 2017 Sep; 38(9):837-847. PubMed ID: 28648526
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Comparing Class A GPCRs to bitter taste receptors: Structural motifs, ligand interactions and agonist-to-antagonist ratios.
    Di Pizio A; Levit A; Slutzki M; Behrens M; Karaman R; Niv MY
    Methods Cell Biol; 2016; 132():401-27. PubMed ID: 26928553
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Does the Lipid Bilayer Orchestrate Access and Binding of Ligands to Transmembrane Orthosteric/Allosteric Sites of G Protein-Coupled Receptors?
    Szlenk CT; Gc JB; Natesan S
    Mol Pharmacol; 2019 Nov; 96(5):527-541. PubMed ID: 30967440
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 20.