BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

230 related articles for article (PubMed ID: 25544127)

  • 1. Cks1 proteasomal degradation is induced by inhibiting Hsp90-mediated chaperoning in cancer cells.
    Khattar V; Fried J; Xu B; Thottassery JV
    Cancer Chemother Pharmacol; 2015 Feb; 75(2):411-20. PubMed ID: 25544127
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Molecular mechanism of 17-allylamino-17-demethoxygeldanamycin (17-AAG)-induced AXL receptor tyrosine kinase degradation.
    Krishnamoorthy GP; Guida T; Alfano L; Avilla E; Santoro M; Carlomagno F; Melillo RM
    J Biol Chem; 2013 Jun; 288(24):17481-94. PubMed ID: 23629654
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Vorinostat enhances protein stability of p27 and p21 through negative regulation of Skp2 and Cks1 in human breast cancer cells.
    Uehara N; Yoshizawa K; Tsubura A
    Oncol Rep; 2012 Jul; 28(1):105-10. PubMed ID: 22484732
    [TBL] [Abstract][Full Text] [Related]  

  • 4. TGF-β activates APC through Cdh1 binding for Cks1 and Skp2 proteasomal destruction stabilizing p27kip1 for normal endometrial growth.
    Pavlides SC; Lecanda J; Daubriac J; Pandya UM; Gama P; Blank S; Mittal K; Shukla P; Gold LI
    Cell Cycle; 2016; 15(7):931-47. PubMed ID: 26963853
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Estrogen and progesterone regulate p27kip1 levels via the ubiquitin-proteasome system: pathogenic and therapeutic implications for endometrial cancer.
    Huang KT; Pavlides SC; Lecanda J; Blank SV; Mittal KR; Gold LI
    PLoS One; 2012; 7(9):e46072. PubMed ID: 23029392
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Inhibition of heat shock protein 90 function by 17-allylamino-17-demethoxy-geldanamycin in Hodgkin's lymphoma cells down-regulates Akt kinase, dephosphorylates extracellular signal-regulated kinase, and induces cell cycle arrest and cell death.
    Georgakis GV; Li Y; Rassidakis GZ; Martinez-Valdez H; Medeiros LJ; Younes A
    Clin Cancer Res; 2006 Jan; 12(2):584-90. PubMed ID: 16428504
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inhibitors of SCF-Skp2/Cks1 E3 ligase block estrogen-induced growth stimulation and degradation of nuclear p27kip1: therapeutic potential for endometrial cancer.
    Pavlides SC; Huang KT; Reid DA; Wu L; Blank SV; Mittal K; Guo L; Rothenberg E; Rueda B; Cardozo T; Gold LI
    Endocrinology; 2013 Nov; 154(11):4030-45. PubMed ID: 24035998
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Cks1 regulates cdk1 expression: a novel role during mitotic entry in breast cancer cells.
    Westbrook L; Manuvakhova M; Kern FG; Estes NR; Ramanathan HN; Thottassery JV
    Cancer Res; 2007 Dec; 67(23):11393-401. PubMed ID: 18056467
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Specific small molecule inhibitors of Skp2-mediated p27 degradation.
    Wu L; Grigoryan AV; Li Y; Hao B; Pagano M; Cardozo TJ
    Chem Biol; 2012 Dec; 19(12):1515-24. PubMed ID: 23261596
    [TBL] [Abstract][Full Text] [Related]  

  • 10. High-throughput screening AlphaScreen assay for identification of small-molecule inhibitors of ubiquitin E3 ligase SCFSkp2-Cks1.
    Ungermannova D; Lee J; Zhang G; Dallmann HG; McHenry CS; Liu X
    J Biomol Screen; 2013 Sep; 18(8):910-20. PubMed ID: 23589337
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Oncostatin M induces growth arrest by inhibition of Skp2, Cks1, and cyclin A expression and induced p21 expression.
    Halfter H; Friedrich M; Resch A; Kullmann M; Stögbauer F; Ringelstein EB; Hengst L
    Cancer Res; 2006 Jul; 66(13):6530-9. PubMed ID: 16818624
    [TBL] [Abstract][Full Text] [Related]  

  • 12. 17-AAG and 17-DMAG-induced inhibition of cell proliferation through B-Raf downregulation in WT B-Raf-expressing uveal melanoma cell lines.
    Babchia N; Calipel A; Mouriaux F; Faussat AM; Mascarelli F
    Invest Ophthalmol Vis Sci; 2008 Jun; 49(6):2348-56. PubMed ID: 18281615
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Heat shock protein 90 regulates the stability of MEKK3 in HEK293 cells.
    Fang S; Fu J; Yuan X; Han C; Shi L; Xin Y; Luo L; Yin Z
    Cell Immunol; 2009; 259(1):49-55. PubMed ID: 19560753
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Acquired resistance to HSP90 inhibitor 17-AAG and increased metastatic potential are associated with MUC1 expression in colon carcinoma cells.
    Liu X; Ban LL; Luo G; Li ZY; Li YF; Zhou YC; Wang XC; Jin CG; Ye JG; Ma DD; Xie Q; Huang YG
    Anticancer Drugs; 2016 Jun; 27(5):417-26. PubMed ID: 26872308
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Inhibition of Hsp90 function by ansamycins causes retinoblastoma gene product-dependent G1 arrest.
    Srethapakdi M; Liu F; Tavorath R; Rosen N
    Cancer Res; 2000 Jul; 60(14):3940-6. PubMed ID: 10919672
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Multiple kinase pathways involved in the different de novo sensitivity of pancreatic cancer cell lines to 17-AAG.
    Liu H; Zhang T; Chen R; McConkey DJ; Ward JF; Curley SA
    J Surg Res; 2012 Jul; 176(1):147-53. PubMed ID: 22099584
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Hsp90 rescues PTK6 from proteasomal degradation in breast cancer cells.
    Kang SA; Cho HS; Yoon JB; Chung IK; Lee ST
    Biochem J; 2012 Oct; 447(2):313-20. PubMed ID: 22849407
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Efficacy of Hsp90 inhibition for induction of apoptosis and inhibition of growth in cervical carcinoma cells in vitro and in vivo.
    Schwock J; Pham NA; Cao MP; Hedley DW
    Cancer Chemother Pharmacol; 2008 Apr; 61(4):669-81. PubMed ID: 17579866
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Silencing of HSP90 cochaperone AHA1 expression decreases client protein activation and increases cellular sensitivity to the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin.
    Holmes JL; Sharp SY; Hobbs S; Workman P
    Cancer Res; 2008 Feb; 68(4):1188-97. PubMed ID: 18281495
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis.
    Powers MV; Clarke PA; Workman P
    Cancer Cell; 2008 Sep; 14(3):250-62. PubMed ID: 18772114
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.