BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

215 related articles for article (PubMed ID: 25548164)

  • 1. Human mutations in methylenetetrahydrofolate dehydrogenase 1 impair nuclear de novo thymidylate biosynthesis.
    Field MS; Kamynina E; Watkins D; Rosenblatt DS; Stover PJ
    Proc Natl Acad Sci U S A; 2015 Jan; 112(2):400-5. PubMed ID: 25548164
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Nuclear enrichment of folate cofactors and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) protect de novo thymidylate biosynthesis during folate deficiency.
    Field MS; Kamynina E; Agunloye OC; Liebenthal RP; Lamarre SG; Brosnan ME; Brosnan JT; Stover PJ
    J Biol Chem; 2014 Oct; 289(43):29642-50. PubMed ID: 25213861
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Arsenic trioxide targets MTHFD1 and SUMO-dependent nuclear de novo thymidylate biosynthesis.
    Kamynina E; Lachenauer ER; DiRisio AC; Liebenthal RP; Field MS; Stover PJ
    Proc Natl Acad Sci U S A; 2017 Mar; 114(12):E2319-E2326. PubMed ID: 28265077
    [TBL] [Abstract][Full Text] [Related]  

  • 4. MTHFD1 regulates nuclear de novo thymidylate biosynthesis and genome stability.
    Field MS; Kamynina E; Stover PJ
    Biochimie; 2016 Jul; 126():27-30. PubMed ID: 26853819
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Biochemical analysis of patients with mutations in MTHFD1 and a diagnosis of methylenetetrahydrofolate dehydrogenase 1 deficiency.
    Bidla G; Watkins D; Chéry C; Froese DS; Ells C; Kerachian M; Saskin A; Christensen KE; Gilfix BM; Guéant JL; Rosenblatt DS
    Mol Genet Metab; 2020 Jul; 130(3):179-182. PubMed ID: 32414565
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Folate rescues vitamin B
    Palmer AM; Kamynina E; Field MS; Stover PJ
    Proc Natl Acad Sci U S A; 2017 May; 114(20):E4095-E4102. PubMed ID: 28461497
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Precision Molecular Diagnosis Defines Specific Therapy in Combined Immunodeficiency with Megaloblastic Anemia Secondary to MTHFD1 Deficiency.
    Ramakrishnan KA; Pengelly RJ; Gao Y; Morgan M; Patel SV; Davies EG; Ennis S; Faust SN; Williams AP
    J Allergy Clin Immunol Pract; 2016; 4(6):1160-1166.e10. PubMed ID: 27707659
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Novel inborn error of folate metabolism: identification by exome capture and sequencing of mutations in the MTHFD1 gene in a single proband.
    Watkins D; Schwartzentruber JA; Ganesh J; Orange JS; Kaplan BS; Nunez LD; Majewski J; Rosenblatt DS
    J Med Genet; 2011 Sep; 48(9):590-2. PubMed ID: 21813566
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Alcohol Dehydrogenase 5 Is a Source of Formate for De Novo Purine Biosynthesis in HepG2 Cells.
    Bae S; Chon J; Field MS; Stover PJ
    J Nutr; 2017 Apr; 147(4):499-505. PubMed ID: 28228507
    [No Abstract]   [Full Text] [Related]  

  • 10. Lessons in biology from patients with inherited disorders of vitamin B12 and folate metabolism.
    Watkins D; Rosenblatt DS
    Biochimie; 2016 Jul; 126():3-5. PubMed ID: 27163846
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Severe combined immunodeficiency resulting from mutations in MTHFD1.
    Keller MD; Ganesh J; Heltzer M; Paessler M; Bergqvist AG; Baluarte HJ; Watkins D; Rosenblatt DS; Orange JS
    Pediatrics; 2013 Feb; 131(2):e629-34. PubMed ID: 23296427
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Characterization and review of MTHFD1 deficiency: four new patients, cellular delineation and response to folic and folinic acid treatment.
    Burda P; Kuster A; Hjalmarson O; Suormala T; Bürer C; Lutz S; Roussey G; Christa L; Asin-Cayuela J; Kollberg G; Andersson BA; Watkins D; Rosenblatt DS; Fowler B; Holme E; Froese DS; Baumgartner MR
    J Inherit Metab Dis; 2015 Sep; 38(5):863-72. PubMed ID: 25633902
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A hybrid stochastic model of folate-mediated one-carbon metabolism: Effect of the common C677T MTHFR variant on de novo thymidylate biosynthesis.
    Misselbeck K; Marchetti L; Field MS; Scotti M; Priami C; Stover PJ
    Sci Rep; 2017 Apr; 7(1):797. PubMed ID: 28400561
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Mthfd1 is a modifier of chemically induced intestinal carcinogenesis.
    MacFarlane AJ; Perry CA; McEntee MF; Lin DM; Stover PJ
    Carcinogenesis; 2011 Mar; 32(3):427-33. PubMed ID: 21156972
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Altered folate metabolism modifies cell proliferation and progesterone secretion in human placental choriocarcinoma JEG-3 cells.
    Moussa C; Ross N; Jolette P; MacFarlane AJ
    Br J Nutr; 2015 Sep; 114(6):844-52. PubMed ID: 26299783
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The MTHFD1 p.Arg653Gln variant alters enzyme function and increases risk for congenital heart defects.
    Christensen KE; Rohlicek CV; Andelfinger GU; Michaud J; Bigras JL; Richter A; Mackenzie RE; Rozen R
    Hum Mutat; 2009 Feb; 30(2):212-20. PubMed ID: 18767138
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Targeting nuclear thymidylate biosynthesis.
    Chon J; Stover PJ; Field MS
    Mol Aspects Med; 2017 Feb; 53():48-56. PubMed ID: 27876557
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism.
    MacFarlane AJ; Perry CA; Girnary HH; Gao D; Allen RH; Stabler SP; Shane B; Stover PJ
    J Biol Chem; 2009 Jan; 284(3):1533-9. PubMed ID: 19033438
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Murine MTHFD1-synthetase deficiency, a model for the human MTHFD1 R653Q polymorphism, decreases growth of colorectal tumors.
    Lévesque N; Christensen KE; Van Der Kraak L; Best AF; Deng L; Caldwell D; MacFarlane AJ; Beauchemin N; Rozen R
    Mol Carcinog; 2017 Mar; 56(3):1030-1040. PubMed ID: 27597531
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells.
    Green AC; Marttila P; Kiweler N; Chalkiadaki C; Wiita E; Cookson V; Lesur A; Eiden K; Bernardin F; Vallin KSA; Borhade S; Long M; Ghahe EK; Jiménez-Alonso JJ; Jemth AS; Loseva O; Mortusewicz O; Meyers M; Viry E; Johansson AI; Hodek O; Homan E; Bonagas N; Ramos L; Sandberg L; Frödin M; Moussay E; Slipicevic A; Letellier E; Paggetti J; Sørensen CS; Helleday T; Henriksson M; Meiser J
    Nat Metab; 2023 Apr; 5(4):642-659. PubMed ID: 37012496
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.