BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

453 related articles for article (PubMed ID: 25549280)

  • 1. Small molecule inhibitors of bromodomain-acetyl-lysine interactions.
    Brand M; Measures AR; Wilson BG; Cortopassi WA; Alexander R; Höss M; Hewings DS; Rooney TP; Paton RS; Conway SJ
    ACS Chem Biol; 2015 Jan; 10(1):22-39. PubMed ID: 25549280
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Disrupting Acetyl-Lysine Recognition: Progress in the Development of Bromodomain Inhibitors.
    Romero FA; Taylor AM; Crawford TD; Tsui V; Côté A; Magnuson S
    J Med Chem; 2016 Feb; 59(4):1271-98. PubMed ID: 26572217
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Bromodomains and their pharmacological inhibitors.
    Gallenkamp D; Gelato KA; Haendler B; Weinmann H
    ChemMedChem; 2014 Mar; 9(3):438-64. PubMed ID: 24497428
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Progress in the development and application of small molecule inhibitors of bromodomain-acetyl-lysine interactions.
    Hewings DS; Rooney TP; Jennings LE; Hay DA; Schofield CJ; Brennan PE; Knapp S; Conway SJ
    J Med Chem; 2012 Nov; 55(22):9393-413. PubMed ID: 22924434
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Metabolically Derived Lysine Acylations and Neighboring Modifications Tune the Binding of the BET Bromodomains to Histone H4.
    Olp MD; Zhu N; Smith BC
    Biochemistry; 2017 Oct; 56(41):5485-5495. PubMed ID: 28945351
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Polybromo-1-bromodomains bind histone H3 at specific acetyl-lysine positions.
    Chandrasekaran R; Thompson M
    Biochem Biophys Res Commun; 2007 Apr; 355(3):661-6. PubMed ID: 17320048
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The bromodomain: from epigenome reader to druggable target.
    Sanchez R; Meslamani J; Zhou MM
    Biochim Biophys Acta; 2014 Aug; 1839(8):676-85. PubMed ID: 24686119
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Phenotypic screening and fragment-based approaches to the discovery of small-molecule bromodomain ligands.
    Jennings LE; Measures AR; Wilson BG; Conway SJ
    Future Med Chem; 2014 Feb; 6(2):179-204. PubMed ID: 24467243
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structural ramification for acetyl-lysine recognition by the bromodomain of human BRG1 protein, a central ATPase of the SWI/SNF remodeling complex.
    Singh M; Popowicz GM; Krajewski M; Holak TA
    Chembiochem; 2007 Jul; 8(11):1308-16. PubMed ID: 17582821
    [TBL] [Abstract][Full Text] [Related]  

  • 10. 3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands.
    Hewings DS; Wang M; Philpott M; Fedorov O; Uttarkar S; Filippakopoulos P; Picaud S; Vuppusetty C; Marsden B; Knapp S; Conway SJ; Heightman TD
    J Med Chem; 2011 Oct; 54(19):6761-70. PubMed ID: 21851057
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Bromodomain Histone Readers and Cancer.
    Jain AK; Barton MC
    J Mol Biol; 2017 Jun; 429(13):2003-2010. PubMed ID: 27890782
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Selective recognition of acetylated histones by bromodomains in transcriptional co-activators.
    Hassan AH; Awad S; Al-Natour Z; Othman S; Mustafa F; Rizvi TA
    Biochem J; 2007 Feb; 402(1):125-33. PubMed ID: 17049045
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery of BRD4 bromodomain inhibitors by fragment-based high-throughput docking.
    Zhao H; Gartenmann L; Dong J; Spiliotopoulos D; Caflisch A
    Bioorg Med Chem Lett; 2014 Jun; 24(11):2493-6. PubMed ID: 24767840
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A chemical toolbox for the study of bromodomains and epigenetic signaling.
    Wu Q; Heidenreich D; Zhou S; Ackloo S; Krämer A; Nakka K; Lima-Fernandes E; Deblois G; Duan S; Vellanki RN; Li F; Vedadi M; Dilworth J; Lupien M; Brennan PE; Arrowsmith CH; Müller S; Fedorov O; Filippakopoulos P; Knapp S
    Nat Commun; 2019 Apr; 10(1):1915. PubMed ID: 31015424
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Progress in the discovery of small-molecule inhibitors of bromodomain--histone interactions.
    Chung CW; Witherington J
    J Biomol Screen; 2011 Dec; 16(10):1170-85. PubMed ID: 21956175
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Small molecules as tools to study the chemical epigenetics of lysine acetylation.
    Schiedel M; Conway SJ
    Curr Opin Chem Biol; 2018 Aug; 45():166-178. PubMed ID: 29958150
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Cooperative binding of two acetylation marks on a histone tail by a single bromodomain.
    Morinière J; Rousseaux S; Steuerwald U; Soler-López M; Curtet S; Vitte AL; Govin J; Gaucher J; Sadoul K; Hart DJ; Krijgsveld J; Khochbin S; Müller CW; Petosa C
    Nature; 2009 Oct; 461(7264):664-8. PubMed ID: 19794495
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The exploitation of FRET probes to track bromodomain/histone interactions in cells for bromodomain inhibitors.
    Sasaki K; Yoshida M
    Drug Discov Today Technol; 2016 Mar; 19():51-56. PubMed ID: 27769358
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Binding Mode of Acetylated Histones to Bromodomains: Variations on a Common Motif.
    Marchand JR; Caflisch A
    ChemMedChem; 2015 Aug; 10(8):1327-33. PubMed ID: 26033856
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structure and acetyl-lysine recognition of the bromodomain.
    Mujtaba S; Zeng L; Zhou MM
    Oncogene; 2007 Aug; 26(37):5521-7. PubMed ID: 17694091
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 23.