BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

107 related articles for article (PubMed ID: 25555733)

  • 1. Synthesis and biological evaluation of isoindoloisoquinolinone, pyroloisoquinolinone and benzoquinazolinone derivatives as poly(ADP-ribose) polymerase-1 inhibitors.
    Suyavaran A; Ramamurthy C; Mareeswaran R; Shanthi YV; Selvakumar J; Mangalaraj S; Kumar MS; Ramanathan CR; Thirunavukkarasu C
    Bioorg Med Chem; 2015 Feb; 23(3):488-98. PubMed ID: 25555733
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Rational design of conformationally restricted quinazolinone inhibitors of poly(ADP-ribose)polymerase.
    Hattori K; Kido Y; Yamamoto H; Ishida J; Iwashita A; Mihara K
    Bioorg Med Chem Lett; 2007 Oct; 17(20):5577-81. PubMed ID: 17804225
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis of isoquinolinone-based tricycles as novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors.
    Chen J; Peng H; He J; Huan X; Miao Z; Yang C
    Bioorg Med Chem Lett; 2014 Jun; 24(12):2669-73. PubMed ID: 24815508
    [TBL] [Abstract][Full Text] [Related]  

  • 4. [Design, synthesis and biological evaluation of novel para-substituted 1-benzyl-quinazoline-2, 4 (1H, 3H)-diones as human PARP-1 inhibitors].
    Yao HP; Zhu ZX; Ji M; Chen XG; Xu BL
    Yao Xue Xue Bao; 2014 Apr; 49(4):497-503. PubMed ID: 24974467
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Identification of novel PARP-1 inhibitors by structure-based virtual screening.
    Hannigan K; Kulkarni SS; Bdzhola VG; Golub AG; Yarmoluk SM; Talele TT
    Bioorg Med Chem Lett; 2013 Nov; 23(21):5790-4. PubMed ID: 24074844
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Identification of substituted pyrazolo[1,5-a]quinazolin-5(4H)-one as potent poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors.
    Orvieto F; Branca D; Giomini C; Jones P; Koch U; Ontoria JM; Palumbi MC; Rowley M; Toniatti C; Muraglia E
    Bioorg Med Chem Lett; 2009 Aug; 19(15):4196-200. PubMed ID: 19541484
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery of potent poly(ADP-ribose) polymerase-1 inhibitors from the modification of indeno[1,2-c]isoquinolinone.
    Jagtap PG; Baloglu E; Southan GJ; Mabley JG; Li H; Zhou J; van Duzer J; Salzman AL; Szabó C
    J Med Chem; 2005 Aug; 48(16):5100-3. PubMed ID: 16078828
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Towards new neuroprotective agents: design and synthesis of 4H-thieno[2,3-c] isoquinolin-5-one derivatives as potent PARP-1 inhibitors.
    Pellicciari R; Camaioni E; Costantino G; Marinozzi M; Macchiarulo A; Moroni F; Natalini B
    Farmaco; 2003 Sep; 58(9):851-8. PubMed ID: 13679179
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis of isoquinolinone-based tetracycles as poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors.
    Rhee HK; Lim SY; Jung MJ; Kwon Y; Kim MH; Choo HY
    Bioorg Med Chem; 2009 Nov; 17(21):7537-41. PubMed ID: 19800803
    [TBL] [Abstract][Full Text] [Related]  

  • 10. 5-Benzamidoisoquinolin-1-ones and 5-(ω-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2).
    Sunderland PT; Woon EC; Dhami A; Bergin AB; Mahon MF; Wood PJ; Jones LA; Tully SR; Lloyd MD; Thompson AS; Javaid H; Martin NM; Threadgill MD
    J Med Chem; 2011 Apr; 54(7):2049-59. PubMed ID: 21417348
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Novel tricyclic poly(ADP-ribose) polymerase-1 inhibitors with potent anticancer chemopotentiating activity: design, synthesis, and X-ray cocrystal structure.
    Canan Koch SS; Thoresen LH; Tikhe JG; Maegley KA; Almassy RJ; Li J; Yu XH; Zook SE; Kumpf RA; Zhang C; Boritzki TJ; Mansour RN; Zhang KE; Ekker A; Calabrese CR; Curtin NJ; Kyle S; Thomas HD; Wang LZ; Calvert AH; Golding BT; Griffin RJ; Newell DR; Webber SE; Hostomsky Z
    J Med Chem; 2002 Nov; 45(23):4961-74. PubMed ID: 12408707
    [TBL] [Abstract][Full Text] [Related]  

  • 12. On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives.
    Pellicciari R; Camaioni E; Costantino G; Formentini L; Sabbatini P; Venturoni F; Eren G; Bellocchi D; Chiarugi A; Moroni F
    ChemMedChem; 2008 Jun; 3(6):914-23. PubMed ID: 18409175
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Identification of novel PARP-1 inhibitors: Drug design, synthesis and biological evaluation.
    Xie Z; Zhou Y; Zhao W; Jiao H; Chen Y; Yang Y; Li Z
    Bioorg Med Chem Lett; 2015 Oct; 25(20):4557-61. PubMed ID: 26342868
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery of quinazolinone and quinoxaline derivatives as potent and selective poly(ADP-ribose) polymerase-1/2 inhibitors.
    Iwashita A; Hattori K; Yamamoto H; Ishida J; Kido Y; Kamijo K; Murano K; Miyake H; Kinoshita T; Warizaya M; Ohkubo M; Matsuoka N; Mutoh S
    FEBS Lett; 2005 Feb; 579(6):1389-93. PubMed ID: 15733846
    [TBL] [Abstract][Full Text] [Related]  

  • 15. PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3.
    Lindgren AE; Karlberg T; Thorsell AG; Hesse M; Spjut S; Ekblad T; Andersson CD; Pinto AF; Weigelt J; Hottiger MO; Linusson A; Elofsson M; Schüler H
    ACS Chem Biol; 2013 Aug; 8(8):1698-703. PubMed ID: 23742272
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Novel isoquinolinone-derived inhibitors of poly(ADP-ribose) polymerase-1: pharmacological characterization and neuroprotective effects in an in vitro model of cerebral ischemia.
    Chiarugi A; Meli E; Calvani M; Picca R; Baronti R; Camaioni E; Costantino G; Marinozzi M; Pellegrini-Giampietro DE; Pellicciari R; Moroni F
    J Pharmacol Exp Ther; 2003 Jun; 305(3):943-9. PubMed ID: 12606624
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Identification of ring-fused pyrazolo pyridin-2-ones as novel poly(ADP-ribose)polymerase-1 inhibitors.
    Moree WJ; Goldman P; Demaggio AJ; Christenson E; Herendeen D; Eksterowicz J; Kesicki EA; McElligott DL; Beaton G
    Bioorg Med Chem Lett; 2008 Sep; 18(18):5126-9. PubMed ID: 18713665
    [TBL] [Abstract][Full Text] [Related]  

  • 18. One-pot tandem Hurtley-retro-Claisen-cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs.
    Woon EC; Sunderland PT; Paine HA; Lloyd MD; Thompson AS; Threadgill MD
    Bioorg Med Chem; 2013 Sep; 21(17):5218-27. PubMed ID: 23849206
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Design, synthesis, and evaluation of 3,4-dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones as inhibitors of poly(ADP-ribose) polymerase.
    Tikhe JG; Webber SE; Hostomsky Z; Maegley KA; Ekkers A; Li J; Yu XH; Almassy RJ; Kumpf RA; Boritzki TJ; Zhang C; Calabrese CR; Curtin NJ; Kyle S; Thomas HD; Wang LZ; Calvert AH; Golding BT; Griffin RJ; Newell DR
    J Med Chem; 2004 Oct; 47(22):5467-81. PubMed ID: 15481984
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors.
    Eltze T; Boer R; Wagner T; Weinbrenner S; McDonald MC; Thiemermann C; Bürkle A; Klein T
    Mol Pharmacol; 2008 Dec; 74(6):1587-98. PubMed ID: 18809672
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.