BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

199 related articles for article (PubMed ID: 25556098)

  • 1. Selective CB2 receptor agonists. Part 1: the identification of novel ligands through computer-aided drug design (CADD) approaches.
    Hickey ER; Zindell R; Cirillo PF; Wu L; Ermann M; Berry AK; Thomson DS; Albrecht C; Gemkow MJ; Riether D
    Bioorg Med Chem Lett; 2015 Feb; 25(3):575-80. PubMed ID: 25556098
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Selective CB2 receptor agonists. Part 3: the optimization of a piperidine-based series that demonstrated efficacy in an in vivo neuropathic pain model.
    Bartolozzi A; Cirillo PF; Berry AK; Hickey ER; Thomson DS; Wu L; Zindell R; Albrecht C; Ceci A; Gemkow MJ; Nagaraja NV; Romig H; Sauer A; Riether D
    Bioorg Med Chem Lett; 2015 Feb; 25(3):587-92. PubMed ID: 25575658
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Selective CB2 receptor agonists. Part 2: Structure-activity relationship studies and optimization of proline-based compounds.
    Riether D; Zindell R; Wu L; Betageri R; Jenkins JE; Khor S; Berry AK; Hickey ER; Ermann M; Albrecht C; Ceci A; Gemkow MJ; Nagaraja NV; Romig H; Sauer A; Thomson DS
    Bioorg Med Chem Lett; 2015 Feb; 25(3):581-6. PubMed ID: 25556092
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of novel cannabinoid receptor ligands by a virtual screening approach: further development of 2,4,6-trisubstituted 1,3,5-triazines as CB2 agonists.
    Yrjölä S; Kalliokoski T; Laitinen T; Poso A; Parkkari T; Nevalainen T
    Eur J Pharm Sci; 2013 Jan; 48(1-2):9-20. PubMed ID: 23131798
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Aryl 1,4-diazepane compounds as potent and selective CB2 agonists: optimization of drug-like properties and target independent parameters.
    Zindell R; Walker ER; Scott J; Amouzegh P; Wu L; Ermann M; Thomson D; Fisher MB; Fullenwider CL; Grbic H; Kaplita P; Linehan B; Patel M; Patel M; Löbbe S; Block S; Albrecht C; Gemkow MJ; Shih DT; Riether D
    Bioorg Med Chem Lett; 2011 Jul; 21(14):4276-80. PubMed ID: 21689933
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Novel pyridine derivatives as potent and selective CB2 cannabinoid receptor agonists.
    Chu GH; Saeui CT; Worm K; Weaver DG; Goodman AJ; Broadrup RL; Cassel JA; DeHaven RN; LaBuda CJ; Koblish M; Brogdon B; Smith S; Le Bourdonnec B; Dolle RE
    Bioorg Med Chem Lett; 2009 Oct; 19(20):5931-5. PubMed ID: 19736007
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and biological evaluation of bivalent cannabinoid receptor ligands based on hCB₂R selective benzimidazoles reveal unexpected intrinsic properties.
    Nimczick M; Pemp D; Darras FH; Chen X; Heilmann J; Decker M
    Bioorg Med Chem; 2014 Aug; 22(15):3938-46. PubMed ID: 24984935
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery of a novel class of selective human CB1 inverse agonists.
    Foloppe N; Allen NH; Bentley CH; Brooks TD; Kennett G; Knight AR; Leonardi S; Misra A; Monck NJ; Sellwood DM
    Bioorg Med Chem Lett; 2008 Feb; 18(3):1199-206. PubMed ID: 18083560
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Optimisation of a novel series of selective CNS penetrant CB(2) agonists.
    Watson C; Owen DR; Harding D; Kon-I K; Lewis ML; Mason HJ; Matsumizu M; Mukaiyama T; Rodriguez-Lens M; Shima A; Takeuchi M; Tran I; Young T
    Bioorg Med Chem Lett; 2011 Jul; 21(14):4284-7. PubMed ID: 21669533
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Design, syntheses, structure-activity relationships and docking studies of coumarin derivatives as novel selective ligands for the CB2 receptor.
    Han S; Zhang FF; Qian HY; Chen LL; Pu JB; Xie X; Chen JZ
    Eur J Med Chem; 2015 Mar; 93():16-32. PubMed ID: 25644673
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Investigations on the 4-quinolone-3-carboxylic acid motif. 6. Synthesis and pharmacological evaluation of 7-substituted quinolone-3-carboxamide derivatives as high affinity ligands for cannabinoid receptors.
    Pasquini S; De Rosa M; Ligresti A; Mugnaini C; Brizzi A; Caradonna NP; Cascio MG; Bolognini D; Pertwee RG; Di Marzo V; Corelli F
    Eur J Med Chem; 2012 Dec; 58():30-43. PubMed ID: 23085772
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Latest advances in cannabinoid receptor agonists.
    Thakur GA; Tichkule R; Bajaj S; Makriyannis A
    Expert Opin Ther Pat; 2009 Dec; 19(12):1647-73. PubMed ID: 19939187
    [TBL] [Abstract][Full Text] [Related]  

  • 13. 5-Sulfonyl-benzimidazoles as selective CB2 agonists.
    Verbist BM; De Cleyn MA; Surkyn M; Fraiponts E; Aerssens J; Nijsen MJ; Gijsen HJ
    Bioorg Med Chem Lett; 2008 Apr; 18(8):2574-9. PubMed ID: 18394887
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Microwave-assisted synthesis of quinoline, isoquinoline, quinoxaline and quinazoline derivatives as CB2 receptor agonists.
    Saari R; Törmä JC; Nevalainen T
    Bioorg Med Chem; 2011 Jan; 19(2):939-50. PubMed ID: 21215643
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The SAR development of substituted purine derivatives as selective CB2 agonists for the treatment of chronic pain.
    Guidetti R; Astles PC; Sanderson AJ; Hollinshead SP; Johnson MP; Chambers MG
    Bioorg Med Chem Lett; 2014 Dec; 24(24):5572-5575. PubMed ID: 25466177
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design, synthesis and biological evaluation of piperazine analogues as CB1 cannabinoid receptor ligands.
    Song KS; Lee SH; Chun HJ; Kim JY; Jung ME; Ahn K; Kim SU; Kim J; Lee J
    Bioorg Med Chem; 2008 Apr; 16(7):4035-51. PubMed ID: 18243711
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Discovery of novel Tetrahydrobenzo[b]thiophene and pyrrole based scaffolds as potent and selective CB2 receptor ligands: The structural elements controlling binding affinity, selectivity and functionality.
    Osman NA; Ligresti A; Klein CD; Allarà M; Rabbito A; Di Marzo V; Abouzid KA; Abadi AH
    Eur J Med Chem; 2016 Oct; 122():619-634. PubMed ID: 27448919
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis and biological evaluation of (3',5'-dichloro-2,6-dihydroxy-biphenyl-4-yl)-aryl/alkyl-methanone selective CB2 inverse agonist.
    Presley CS; Mustafa SM; Abidi AH; Moore BM
    Bioorg Med Chem; 2015 Sep; 23(17):5390-401. PubMed ID: 26275680
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration.
    Dziadulewicz EK; Bevan SJ; Brain CT; Coote PR; Culshaw AJ; Davis AJ; Edwards LJ; Fisher AJ; Fox AJ; Gentry C; Groarke A; Hart TW; Huber W; James IF; Kesingland A; La Vecchia L; Loong Y; Lyothier I; McNair K; O'Farrell C; Peacock M; Portmann R; Schopfer U; Yaqoob M; Zadrobilek J
    J Med Chem; 2007 Aug; 50(16):3851-6. PubMed ID: 17630726
    [TBL] [Abstract][Full Text] [Related]  

  • 20. 7-Oxo-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamides as selective CB(2) cannabinoid receptor ligands: structural investigations around a novel class of full agonists.
    Baraldi PG; Saponaro G; Moorman AR; Romagnoli R; Preti D; Baraldi S; Ruggiero E; Varani K; Targa M; Vincenzi F; Borea PA; Aghazadeh Tabrizi M
    J Med Chem; 2012 Jul; 55(14):6608-23. PubMed ID: 22738271
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.