967 related articles for article (PubMed ID: 25559441)
1. Rational design of viscosity reducing mutants of a monoclonal antibody: hydrophobic versus electrostatic inter-molecular interactions.
Nichols P; Li L; Kumar S; Buck PM; Singh SK; Goswami S; Balthazor B; Conley TR; Sek D; Allen MJ
MAbs; 2015; 7(1):212-30. PubMed ID: 25559441
[TBL] [Abstract][Full Text] [Related]
2. Differences in human IgG1 and IgG4 S228P monoclonal antibodies viscosity and self-interactions: Experimental assessment and computational predictions of domain interactions.
Lai PK; Ghag G; Yu Y; Juan V; Fayadat-Dilman L; Trout BL
MAbs; 2021; 13(1):1991256. PubMed ID: 34747330
[TBL] [Abstract][Full Text] [Related]
3. Hydrogen exchange mass spectrometry reveals protein interfaces and distant dynamic coupling effects during the reversible self-association of an IgG1 monoclonal antibody.
Arora J; Hickey JM; Majumdar R; Esfandiary R; Bishop SM; Samra HS; Middaugh CR; Weis DD; Volkin DB
MAbs; 2015; 7(3):525-39. PubMed ID: 25875351
[TBL] [Abstract][Full Text] [Related]
4. Correlations between changes in conformational dynamics and physical stability in a mutant IgG1 mAb engineered for extended serum half-life.
Majumdar R; Esfandiary R; Bishop SM; Samra HS; Middaugh CR; Volkin DB; Weis DD
MAbs; 2015; 7(1):84-95. PubMed ID: 25524268
[TBL] [Abstract][Full Text] [Related]
5. Solubility Challenges in High Concentration Monoclonal Antibody Formulations: Relationship with Amino Acid Sequence and Intermolecular Interactions.
Pindrus M; Shire SJ; Kelley RF; Demeule B; Wong R; Xu Y; Yadav S
Mol Pharm; 2015 Nov; 12(11):3896-907. PubMed ID: 26407030
[TBL] [Abstract][Full Text] [Related]
6. Highly viscous antibody solutions are a consequence of network formation caused by domain-domain electrostatic complementarities: insights from coarse-grained simulations.
Buck PM; Chaudhri A; Kumar S; Singh SK
Mol Pharm; 2015 Jan; 12(1):127-39. PubMed ID: 25383990
[TBL] [Abstract][Full Text] [Related]
7. Charge-mediated Fab-Fc interactions in an IgG1 antibody induce reversible self-association, cluster formation, and elevated viscosity.
Arora J; Hu Y; Esfandiary R; Sathish HA; Bishop SM; Joshi SB; Middaugh CR; Volkin DB; Weis DD
MAbs; 2016; 8(8):1561-1574. PubMed ID: 27560842
[TBL] [Abstract][Full Text] [Related]
8. Domain interactions and antigen binding of recombinant anti-Z-DNA antibody variable domains. The role of heavy and light chains measured by surface plasmon resonance.
Polymenis M; Stollar BD
J Immunol; 1995 Mar; 154(5):2198-208. PubMed ID: 7868893
[TBL] [Abstract][Full Text] [Related]
9. Optimal charged mutations in the complementarity-determining regions that prevent domain antibody aggregation are dependent on the antibody scaffold.
Perchiacca JM; Lee CC; Tessier PM
Protein Eng Des Sel; 2014 Feb; 27(2):29-39. PubMed ID: 24398633
[TBL] [Abstract][Full Text] [Related]
10. Viscosity behavior of high-concentration monoclonal antibody solutions: correlation with interaction parameter and electroviscous effects.
Yadav S; Shire SJ; Kalonia DS
J Pharm Sci; 2012 Mar; 101(3):998-1011. PubMed ID: 22113861
[TBL] [Abstract][Full Text] [Related]
11. Developability Assessment of Engineered Monoclonal Antibody Variants with a Complex Self-Association Behavior Using Complementary Analytical and in Silico Tools.
Shan L; Mody N; Sormani P; Rosenthal KL; Damschroder MM; Esfandiary R
Mol Pharm; 2018 Dec; 15(12):5697-5710. PubMed ID: 30395473
[TBL] [Abstract][Full Text] [Related]
12. Therapeutic Antibody Engineering To Improve Viscosity and Phase Separation Guided by Crystal Structure.
Chow CK; Allan BW; Chai Q; Atwell S; Lu J
Mol Pharm; 2016 Mar; 13(3):915-23. PubMed ID: 26849155
[TBL] [Abstract][Full Text] [Related]
13. Full-length recombinant antibodies from
Rashid MH
MAbs; 2022; 14(1):2111748. PubMed ID: 36018829
[TBL] [Abstract][Full Text] [Related]
14. Contrasting the Influence of Cationic Amino Acids on the Viscosity and Stability of a Highly Concentrated Monoclonal Antibody.
Dear BJ; Hung JJ; Truskett TM; Johnston KP
Pharm Res; 2017 Jan; 34(1):193-207. PubMed ID: 27837522
[TBL] [Abstract][Full Text] [Related]
15. DNA binding by the VH domain of anti-Z-DNA antibody and its modulation by association of the VL domain.
Chen Y; Stollar BD
J Immunol; 1999 Apr; 162(8):4663-70. PubMed ID: 10202006
[TBL] [Abstract][Full Text] [Related]
16. The influence of charge distribution on self-association and viscosity behavior of monoclonal antibody solutions.
Yadav S; Laue TM; Kalonia DS; Singh SN; Shire SJ
Mol Pharm; 2012 Apr; 9(4):791-802. PubMed ID: 22352470
[TBL] [Abstract][Full Text] [Related]
17. Homology modeling and structure-based design improve hydrophobic interaction chromatography behavior of integrin binding antibodies.
Jetha A; Thorsteinson N; Jmeian Y; Jeganathan A; Giblin P; Fransson J
MAbs; 2018; 10(6):890-900. PubMed ID: 30110240
[TBL] [Abstract][Full Text] [Related]
18. Comparative properties of the single chain antibody and Fv derivatives of mAb 4-4-20. Relationship between interdomain interactions and the high affinity for fluorescein ligand.
Mallender WD; Carrero J; Voss EW
J Biol Chem; 1996 Mar; 271(10):5338-46. PubMed ID: 8621386
[TBL] [Abstract][Full Text] [Related]
19. Process optimization and protein engineering mitigated manufacturing challenges of a monoclonal antibody with liquid-liquid phase separation issue by disrupting inter-molecule electrostatic interactions.
Du Q; Damschroder M; Pabst TM; Hunter AK; Wang WK; Luo H
MAbs; 2019; 11(4):789-802. PubMed ID: 30913985
[TBL] [Abstract][Full Text] [Related]
20. Characterization of a recombinant humanized anti-cocaine monoclonal antibody and its Fab fragment.
Kirley TL; Norman AB
Hum Vaccin Immunother; 2015; 11(2):458-67. PubMed ID: 25692880
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
