These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

259 related articles for article (PubMed ID: 25564664)

  • 1. Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1.
    Capper MJ; O'Neill PM; Fisher N; Strange RW; Moss D; Ward SA; Berry NG; Lawrenson AS; Hasnain SS; Biagini GA; Antonyuk SV
    Proc Natl Acad Sci U S A; 2015 Jan; 112(3):755-60. PubMed ID: 25564664
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Exploration of 4(1H)-pyridones as a novel family of potent antimalarial inhibitors of the plasmodial cytochrome bc1.
    Bueno JM; Herreros E; Angulo-Barturen I; Ferrer S; Fiandor JM; Gamo FJ; Gargallo-Viola D; Derimanov G
    Future Med Chem; 2012 Dec; 4(18):2311-23. PubMed ID: 23234553
    [TBL] [Abstract][Full Text] [Related]  

  • 3. In silico design, chemical synthesis and biological screening of novel 4-(1H)-pyridone-based antimalarial agents.
    Audu O; Stander A; Ajani O; Egieyeh S; October N
    Chem Biol Drug Des; 2022 May; 99(5):674-687. PubMed ID: 34850571
    [TBL] [Abstract][Full Text] [Related]  

  • 4. HDQ, a potent inhibitor of Plasmodium falciparum proliferation, binds to the quinone reduction site of the cytochrome bc1 complex.
    Vallières C; Fisher N; Antoine T; Al-Helal M; Stocks P; Berry NG; Lawrenson AS; Ward SA; O'Neill PM; Biagini GA; Meunier B
    Antimicrob Agents Chemother; 2012 Jul; 56(7):3739-47. PubMed ID: 22547613
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structural analysis of atovaquone-inhibited cytochrome bc1 complex reveals the molecular basis of antimalarial drug action.
    Birth D; Kao WC; Hunte C
    Nat Commun; 2014 Jun; 5():4029. PubMed ID: 24893593
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Direct evidence for the atovaquone action on the Plasmodium cytochrome bc1 complex.
    Siregar JE; Kurisu G; Kobayashi T; Matsuzaki M; Sakamoto K; Mi-ichi F; Watanabe Y; Hirai M; Matsuoka H; Syafruddin D; Marzuki S; Kita K
    Parasitol Int; 2015 Jun; 64(3):295-300. PubMed ID: 25264100
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparum.
    Stickles AM; de Almeida MJ; Morrisey JM; Sheridan KA; Forquer IP; Nilsen A; Winter RW; Burrows JN; Fidock DA; Vaidya AB; Riscoe MK
    Antimicrob Agents Chemother; 2015 Apr; 59(4):1977-82. PubMed ID: 25605352
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Targeting the Ubiquinol-Reduction (Q
    Amporndanai K; Pinthong N; O'Neill PM; Hong WD; Amewu RK; Pidathala C; Berry NG; Leung SC; Ward SA; Biagini GA; Hasnain SS; Antonyuk SV
    Biology (Basel); 2022 Jul; 11(8):. PubMed ID: 35892964
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Targeted Structure-Activity Analysis of Endochin-like Quinolones Reveals Potent Qi and Qo Site Inhibitors of Toxoplasma gondii and Plasmodium falciparum Cytochrome bc
    McConnell EV; Bruzual I; Pou S; Winter R; Dodean RA; Smilkstein MJ; Krollenbrock A; Nilsen A; Zakharov LN; Riscoe MK; Doggett JS
    ACS Infect Dis; 2018 Nov; 4(11):1574-1584. PubMed ID: 30117728
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Atovaquone and ELQ-300 Combination Therapy as a Novel Dual-Site Cytochrome bc1 Inhibition Strategy for Malaria.
    Stickles AM; Smilkstein MJ; Morrisey JM; Li Y; Forquer IP; Kelly JX; Pou S; Winter RW; Nilsen A; Vaidya AB; Riscoe MK
    Antimicrob Agents Chemother; 2016 Aug; 60(8):4853-9. PubMed ID: 27270285
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors.
    Dong CK; Urgaonkar S; Cortese JF; Gamo FJ; Garcia-Bustos JF; Lafuente MJ; Patel V; Ross L; Coleman BI; Derbyshire ER; Clish CB; Serrano AE; Cromwell M; Barker RH; Dvorin JD; Duraisingh MT; Wirth DF; Clardy J; Mazitschek R
    Chem Biol; 2011 Dec; 18(12):1602-10. PubMed ID: 22195562
    [TBL] [Abstract][Full Text] [Related]  

  • 12. 2D, 3D-QSAR and molecular docking of 4(1H)-quinolones analogues with antimalarial activities.
    Jiménez Villalobos TP; Gaitán Ibarra R; Montalvo Acosta JJ
    J Mol Graph Model; 2013 Nov; 46():105-24. PubMed ID: 24185373
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Uncovering the molecular mode of action of the antimalarial drug atovaquone using a bacterial system.
    Mather MW; Darrouzet E; Valkova-Valchanova M; Cooley JW; McIntosh MT; Daldal F; Vaidya AB
    J Biol Chem; 2005 Jul; 280(29):27458-65. PubMed ID: 15917236
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Cytochrome b mutations that modify the ubiquinol-binding pocket of the cytochrome bc1 complex and confer anti-malarial drug resistance in Saccharomyces cerevisiae.
    Kessl JJ; Ha KH; Merritt AK; Lange BB; Hill P; Meunier B; Meshnick SR; Trumpower BL
    J Biol Chem; 2005 Apr; 280(17):17142-8. PubMed ID: 15718226
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Inhibition of cytochrome bc1 as a strategy for single-dose, multi-stage antimalarial therapy.
    Stickles AM; Ting LM; Morrisey JM; Li Y; Mather MW; Meermeier E; Pershing AM; Forquer IP; Miley GP; Pou S; Winter RW; Hinrichs DJ; Kelly JX; Kim K; Vaidya AB; Riscoe MK; Nilsen A
    Am J Trop Med Hyg; 2015 Jun; 92(6):1195-201. PubMed ID: 25918204
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The antimalarial compound ELQ-400 is an unusual inhibitor of the bc
    Song Z; Iorga BI; Mounkoro P; Fisher N; Meunier B
    FEBS Lett; 2018 Apr; 592(8):1346-1356. PubMed ID: 29574797
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Inhibiting Plasmodium cytochrome bc1: a complex issue.
    Barton V; Fisher N; Biagini GA; Ward SA; O'Neill PM
    Curr Opin Chem Biol; 2010 Aug; 14(4):440-6. PubMed ID: 20570550
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Acridinediones: selective and potent inhibitors of the malaria parasite mitochondrial bc1 complex.
    Biagini GA; Fisher N; Berry N; Stocks PA; Meunier B; Williams DP; Bonar-Law R; Bray PG; Owen A; O'Neill PM; Ward SA
    Mol Pharmacol; 2008 May; 73(5):1347-55. PubMed ID: 18319379
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Molecular basis for atovaquone binding to the cytochrome bc1 complex.
    Kessl JJ; Lange BB; Merbitz-Zahradnik T; Zwicker K; Hill P; Meunier B; Pálsdóttir H; Hunte C; Meshnick S; Trumpower BL
    J Biol Chem; 2003 Aug; 278(33):31312-8. PubMed ID: 12791689
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Preclinical drug metabolism and pharmacokinetic evaluation of GW844520, a novel anti-malarial mitochondrial electron transport inhibitor.
    Xiang H; McSurdy-Freed J; Moorthy GS; Hugger E; Bambal R; Han C; Ferrer S; Gargallo D; Davis CB
    J Pharm Sci; 2006 Dec; 95(12):2657-72. PubMed ID: 16892205
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.