328 related articles for article (PubMed ID: 25575161)
1. Structural comparisons of ligand-gated ion channels in open, closed, and desensitized states identify a novel propofol-binding site on mammalian γ-aminobutyric acid type A receptors.
Franks NP
Anesthesiology; 2015 Apr; 122(4):787-94. PubMed ID: 25575161
[TBL] [Abstract][Full Text] [Related]
2. Propofol binding to the resting state of the gloeobacter violaceus ligand-gated ion channel (GLIC) induces structural changes in the inter- and intrasubunit transmembrane domain (TMD) cavities.
Ghosh B; Satyshur KA; Czajkowski C
J Biol Chem; 2013 Jun; 288(24):17420-31. PubMed ID: 23640880
[TBL] [Abstract][Full Text] [Related]
3. Anaesthetic binding sites for etomidate and propofol on a GABAA receptor model.
Campagna-Slater V; Weaver DF
Neurosci Lett; 2007 May; 418(1):28-33. PubMed ID: 17412502
[TBL] [Abstract][Full Text] [Related]
4. Allosteric ligands and their binding sites define γ-aminobutyric acid (GABA) type A receptor subtypes.
Olsen RW
Adv Pharmacol; 2015; 73():167-202. PubMed ID: 25637441
[TBL] [Abstract][Full Text] [Related]
5. A chimeric prokaryotic-eukaryotic pentameric ligand gated ion channel reveals interactions between the extracellular and transmembrane domains shape neurosteroid modulation.
Ghosh B; Tsao TW; Czajkowski C
Neuropharmacology; 2017 Oct; 125():343-352. PubMed ID: 28803966
[TBL] [Abstract][Full Text] [Related]
6. Molecular dynamics investigation of Cl(-) transport through the closed and open states of the 2α12β2γ2 GABA(A) receptor.
Xie HB; Wang J; Sha Y; Cheng MS
Biophys Chem; 2013; 180-181():1-9. PubMed ID: 23771165
[TBL] [Abstract][Full Text] [Related]
7. Opposing effects of the anesthetic propofol at pentameric ligand-gated ion channels mediated by a common site.
Lynagh T; Laube B
J Neurosci; 2014 Feb; 34(6):2155-9. PubMed ID: 24501356
[TBL] [Abstract][Full Text] [Related]
8. Common Anesthetic-binding Site for Inhibition of Pentameric Ligand-gated Ion Channels.
Kinde MN; Bu W; Chen Q; Xu Y; Eckenhoff RG; Tang P
Anesthesiology; 2016 Mar; 124(3):664-73. PubMed ID: 26756520
[TBL] [Abstract][Full Text] [Related]
9. Multiple propofol-binding sites in a γ-aminobutyric acid type A receptor (GABAAR) identified using a photoreactive propofol analog.
Jayakar SS; Zhou X; Chiara DC; Dostalova Z; Savechenkov PY; Bruzik KS; Dailey WP; Miller KW; Eckenhoff RG; Cohen JB
J Biol Chem; 2014 Oct; 289(40):27456-68. PubMed ID: 25086038
[TBL] [Abstract][Full Text] [Related]
10. The neural γ
Ayan M; Essiz S
J Mol Model; 2018 Jul; 24(8):206. PubMed ID: 30008086
[TBL] [Abstract][Full Text] [Related]
11. Methionine 286 in transmembrane domain 3 of the GABAA receptor beta subunit controls a binding cavity for propofol and other alkylphenol general anesthetics.
Krasowski MD; Nishikawa K; Nikolaeva N; Lin A; Harrison NL
Neuropharmacology; 2001 Dec; 41(8):952-64. PubMed ID: 11747900
[TBL] [Abstract][Full Text] [Related]
12. Tryptophan and Cysteine Mutations in M1 Helices of α1β3γ2L γ-Aminobutyric Acid Type A Receptors Indicate Distinct Intersubunit Sites for Four Intravenous Anesthetics and One Orphan Site.
Nourmahnad A; Stern AT; Hotta M; Stewart DS; Ziemba AM; Szabo A; Forman SA
Anesthesiology; 2016 Dec; 125(6):1144-1158. PubMed ID: 27753644
[TBL] [Abstract][Full Text] [Related]
13. Common Internal Allosteric Network Links Anesthetic Binding Sites in a Pentameric Ligand-Gated Ion Channel.
Joseph TT; Mincer JS
PLoS One; 2016; 11(7):e0158795. PubMed ID: 27403526
[TBL] [Abstract][Full Text] [Related]
14. Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels.
Fourati Z; Howard RJ; Heusser SA; Hu H; Ruza RR; Sauguet L; Lindahl E; Delarue M
Cell Rep; 2018 Apr; 23(4):993-1004. PubMed ID: 29694907
[TBL] [Abstract][Full Text] [Related]
15. Numerous classes of general anesthetics inhibit etomidate binding to gamma-aminobutyric acid type A (GABAA) receptors.
Li GD; Chiara DC; Cohen JB; Olsen RW
J Biol Chem; 2010 Mar; 285(12):8615-20. PubMed ID: 20083606
[TBL] [Abstract][Full Text] [Related]
16. X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel.
Nury H; Van Renterghem C; Weng Y; Tran A; Baaden M; Dufresne V; Changeux JP; Sonner JM; Delarue M; Corringer PJ
Nature; 2011 Jan; 469(7330):428-31. PubMed ID: 21248852
[TBL] [Abstract][Full Text] [Related]
17. A propofol binding site on mammalian GABAA receptors identified by photolabeling.
Yip GM; Chen ZW; Edge CJ; Smith EH; Dickinson R; Hohenester E; Townsend RR; Fuchs K; Sieghart W; Evers AS; Franks NP
Nat Chem Biol; 2013 Nov; 9(11):715-20. PubMed ID: 24056400
[TBL] [Abstract][Full Text] [Related]
18. Anesthetic sites and allosteric mechanisms of action on Cys-loop ligand-gated ion channels.
Forman SA; Miller KW
Can J Anaesth; 2011 Feb; 58(2):191-205. PubMed ID: 21213095
[TBL] [Abstract][Full Text] [Related]
19. Specificity of intersubunit general anesthetic-binding sites in the transmembrane domain of the human α1β3γ2 γ-aminobutyric acid type A (GABAA) receptor.
Chiara DC; Jayakar SS; Zhou X; Zhang X; Savechenkov PY; Bruzik KS; Miller KW; Cohen JB
J Biol Chem; 2013 Jul; 288(27):19343-57. PubMed ID: 23677991
[TBL] [Abstract][Full Text] [Related]
20. Insights Into Receptor-Based Anesthetic Pharmacophores and Anesthetic-Protein Interactions.
Fahrenbach VS; Bertaccini EJ
Methods Enzymol; 2018; 602():77-95. PubMed ID: 29588042
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]