BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

152 related articles for article (PubMed ID: 25591119)

  • 21. Activity and substrate specificity of the murine STK2 Serine/Threonine kinase that is structurally related to the mitotic regulator protein NIMA of Aspergillus nidulans.
    Hayashi K; Igarashi H; Ogawa M; Sakaguchi N
    Biochem Biophys Res Commun; 1999 Oct; 264(2):449-56. PubMed ID: 10529384
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Identification of novel polo-like kinase 1 inhibitors by a hybrid virtual screening.
    Lu S; Sun SL; Liu HC; Chen YD; Yuan HL; Gao YP; Yang P; Lu T
    Chem Biol Drug Des; 2012 Aug; 80(2):328-39. PubMed ID: 22583481
    [TBL] [Abstract][Full Text] [Related]  

  • 23. An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9.
    Richards MW; O'Regan L; Mas-Droux C; Blot JM; Cheung J; Hoelder S; Fry AM; Bayliss R
    Mol Cell; 2009 Nov; 36(4):560-70. PubMed ID: 19941817
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Structural basis of reversine selectivity in inhibiting Mps1 more potently than aurora B kinase.
    Hiruma Y; Koch A; Dharadhar S; Joosten RP; Perrakis A
    Proteins; 2016 Dec; 84(12):1761-1766. PubMed ID: 27699881
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Identification of 2-anilino-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-ones as dual PLK1/VEGF-R2 kinase inhibitor chemotypes by structure-based lead generation.
    Egert-Schmidt AM; Dreher J; Dunkel U; Kohfeld S; Preu L; Weber H; Ehlert JE; Mutschler B; Totzke F; Schächtele C; Kubbutat MH; Baumann K; Kunick C
    J Med Chem; 2010 Mar; 53(6):2433-42. PubMed ID: 20170163
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Design, synthesis, and biological evaluation of polo-like kinase 1/eukaryotic elongation factor 2 kinase (PLK1/EEF2K) dual inhibitors for regulating breast cancer cells apoptosis and autophagy.
    Pan Z; Chen Y; Liu J; Jiang Q; Yang S; Guo L; He G
    Eur J Med Chem; 2018 Jan; 144():517-528. PubMed ID: 29288948
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Discovery of 4-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamides as novel, highly potent and selective, orally bioavailable inhibitors of Tyrosine Threonine Kinase, TTK.
    Laufer R; Li SW; Liu Y; Ng G; Lang Y; Feher M; Brokx R; Beletskaya I; Hodgson R; Mao G; Plotnikova O; Awrey DE; Mason JM; Wei X; Lin DC; Che Y; Kiarash R; Madeira B; Fletcher GC; Mak TW; Bray MR; Pauls HW
    Bioorg Med Chem Lett; 2016 Aug; 26(15):3562-6. PubMed ID: 27335255
    [TBL] [Abstract][Full Text] [Related]  

  • 28. 2-Aminomethylthieno[3,2-d]pyrimidin-4(3H)-ones bearing 3-methylpyrazole hinge binding moiety: Highly potent, selective, and time-dependent inhibitors of Cdc7 kinase.
    Kurasawa O; Homma M; Oguro Y; Miyazaki T; Mori K; Uchiyama N; Iwai K; Ohashi A; Hara H; Yoshida S; Cho N
    Bioorg Med Chem; 2017 Jul; 25(14):3658-3670. PubMed ID: 28533114
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs.
    van de Kooij B; Creixell P; van Vlimmeren A; Joughin BA; Miller CJ; Haider N; Simpson CD; Linding R; Stambolic V; Turk BE; Yaffe MB
    Elife; 2019 May; 8():. PubMed ID: 31124786
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Aminopyrimidinone cdc7 kinase inhibitors.
    Woods KW; Lai C; Miyashiro JM; Tong Y; Florjancic AS; Han EK; Soni N; Shi Y; Lasko L; Leverson JD; Johnson EF; Shoemaker AR; Penning TD
    Bioorg Med Chem Lett; 2012 Mar; 22(5):1940-3. PubMed ID: 22326396
    [TBL] [Abstract][Full Text] [Related]  

  • 31. A NIMA-related protein kinase suppresses ectopic outgrowth of epidermal cells through its kinase activity and the association with microtubules.
    Motose H; Tominaga R; Wada T; Sugiyama M; Watanabe Y
    Plant J; 2008 Jun; 54(5):829-44. PubMed ID: 18266916
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Identification of PKMYT1 inhibitors by screening the GSK published protein kinase inhibitor set I and II.
    Platzer C; Najjar A; Rohe A; Erdmann F; Sippl W; Schmidt M
    Bioorg Med Chem; 2018 Aug; 26(14):4014-4024. PubMed ID: 29941193
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Identification of indole-3-carboxylic acids as non-ATP-competitive Polo-like kinase 1 (Plk1) inhibitors.
    Liu M; Huang J; Chen DX; Jiang C
    Bioorg Med Chem Lett; 2015 Feb; 25(3):431-4. PubMed ID: 25556101
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Identification and validation of a potent type II inhibitor of inactive polo-like kinase 1.
    Keppner S; Proschak E; Schneider G; Spänkuch B
    ChemMedChem; 2009 Nov; 4(11):1806-9. PubMed ID: 19746360
    [No Abstract]   [Full Text] [Related]  

  • 35. Rational creation and systematic analysis of cervical cancer kinase-inhibitor binding profile.
    Han M; Sun D
    J Comput Aided Mol Des; 2019 Jul; 33(7):689-698. PubMed ID: 31203490
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Drugs by numbers: reaction-driven de novo design of potent and selective anticancer leads.
    Spänkuch B; Keppner S; Lange L; Rodrigues T; Zettl H; Koch CP; Reutlinger M; Hartenfeller M; Schneider P; Schneider G
    Angew Chem Int Ed Engl; 2013 Apr; 52(17):4676-81. PubMed ID: 23166089
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Design, Synthesis, and Docking Studies of New Torin2 Analogs as Potential ATR/mTOR Kinase Inhibitors.
    Shaik A; Bhakuni R; Kirubakaran S
    Molecules; 2018 Apr; 23(5):. PubMed ID: 29695073
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Caught Nek-ing: cilia and centrioles.
    Quarmby LM; Mahjoub MR
    J Cell Sci; 2005 Nov; 118(Pt 22):5161-9. PubMed ID: 16280549
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Discovery of a series of dihydroquinoxalin-2(1H)-ones as selective BET inhibitors from a dual PLK1-BRD4 inhibitor.
    Hu J; Wang Y; Li Y; Xu L; Cao D; Song S; Damaneh MS; Wang X; Meng T; Chen YL; Shen J; Miao Z; Xiong B
    Eur J Med Chem; 2017 Sep; 137():176-195. PubMed ID: 28586718
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Novel benzothiazinones (BTOs) as allosteric modulator or substrate competitive inhibitor of glycogen synthase kinase 3β (GSK-3β) with cellular activity of promoting glucose uptake.
    Zhang P; Li S; Gao Y; Lu W; Huang K; Ye D; Li X; Chu Y
    Bioorg Med Chem Lett; 2014 Dec; 24(24):5639-5643. PubMed ID: 25467150
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 8.