279 related articles for article (PubMed ID: 25593320)
1. Targeting interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) using a novel covalent inhibitor PRN694.
Zhong Y; Dong S; Strattan E; Ren L; Butchar JP; Thornton K; Mishra A; Porcu P; Bradshaw JM; Bisconte A; Owens TD; Verner E; Brameld KA; Funk JO; Hill RJ; Johnson AJ; Dubovsky JA
J Biol Chem; 2015 Mar; 290(10):5960-78. PubMed ID: 25593320
[TBL] [Abstract][Full Text] [Related]
2. A Small Molecule Inhibitor of ITK and RLK Impairs Th1 Differentiation and Prevents Colitis Disease Progression.
Cho HS; Shin HM; Haberstock-Debic H; Xing Y; Owens TD; Funk JO; Hill RJ; Bradshaw JM; Berg LJ
J Immunol; 2015 Nov; 195(10):4822-31. PubMed ID: 26466958
[TBL] [Abstract][Full Text] [Related]
3. ITK and RLK Inhibitor PRN694 Improves Skin Disease in Two Mouse Models of Psoriasis.
Fuhriman JM; Winge MCG; Haberstock-Debic H; Funk JO; Bradshaw JM; Marinkovich MP
J Invest Dermatol; 2018 Apr; 138(4):864-871. PubMed ID: 29129599
[TBL] [Abstract][Full Text] [Related]
4. A negative role for the interleukin-2-inducible T-cell kinase (ITK) in human Foxp3+ TREG differentiation.
Mamontov P; Eberwine RA; Perrigoue J; Das A; Friedman JR; Mora JR
PLoS One; 2019; 14(4):e0215963. PubMed ID: 31022269
[TBL] [Abstract][Full Text] [Related]
5. Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity.
Schaeffer EM; Debnath J; Yap G; McVicar D; Liao XC; Littman DR; Sher A; Varmus HE; Lenardo MJ; Schwartzberg PL
Science; 1999 Apr; 284(5414):638-41. PubMed ID: 10213685
[TBL] [Abstract][Full Text] [Related]
6. Biochemical and genetic analyses of the Tec kinases Itk and Rlk/Txk.
Czar MJ; Debnath J; Schaeffer EM; Lewis CM; Schwartzberg PL
Biochem Soc Trans; 2001 Nov; 29(Pt 6):863-7. PubMed ID: 11709089
[TBL] [Abstract][Full Text] [Related]
7. The role of Tec protein-tyrosine kinase in T cell signaling.
Yang WC; Ghiotto M; Barbarat B; Olive D
J Biol Chem; 1999 Jan; 274(2):607-17. PubMed ID: 9872994
[TBL] [Abstract][Full Text] [Related]
8. Resting lymphocyte kinase (Rlk/Txk) targets lymphoid adaptor SLP-76 in the cooperative activation of interleukin-2 transcription in T-cells.
Schneider H; Guerette B; Guntermann C; Rudd CE
J Biol Chem; 2000 Feb; 275(6):3835-40. PubMed ID: 10660534
[TBL] [Abstract][Full Text] [Related]
9. The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells.
Atherly LO; Lucas JA; Felices M; Yin CC; Reiner SL; Berg LJ
Immunity; 2006 Jul; 25(1):79-91. PubMed ID: 16860759
[TBL] [Abstract][Full Text] [Related]
10. The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development.
Prince AL; Yin CC; Enos ME; Felices M; Berg LJ
Immunol Rev; 2009 Mar; 228(1):115-31. PubMed ID: 19290924
[TBL] [Abstract][Full Text] [Related]
11. RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation.
Rajagopal K; Sommers CL; Decker DC; Mitchell EO; Korthauer U; Sperling AI; Kozak CA; Love PE; Bluestone JA
J Exp Med; 1999 Dec; 190(11):1657-68. PubMed ID: 10587356
[TBL] [Abstract][Full Text] [Related]
12. The Tec kinases Itk and Rlk regulate NKT cell maturation, cytokine production, and survival.
Felices M; Berg LJ
J Immunol; 2008 Mar; 180(5):3007-18. PubMed ID: 18292523
[TBL] [Abstract][Full Text] [Related]
13. Discovery of novel irreversible inhibitors of interleukin (IL)-2-inducible tyrosine kinase (Itk) by targeting cysteine 442 in the ATP pocket.
Harling JD; Deakin AM; Campos S; Grimley R; Chaudry L; Nye C; Polyakova O; Bessant CM; Barton N; Somers D; Barrett J; Graves RH; Hanns L; Kerr WJ; Solari R
J Biol Chem; 2013 Sep; 288(39):28195-206. PubMed ID: 23935099
[TBL] [Abstract][Full Text] [Related]
14. Tec protein tyrosine kinase inhibits CD25 expression in human T-lymphocyte.
Susaki K; Kitanaka A; Dobashi H; Kubota Y; Kittaka K; Kameda T; Yamaoka G; Mano H; Mihara K; Ishida T
Immunol Lett; 2010 Jan; 127(2):135-42. PubMed ID: 19883687
[TBL] [Abstract][Full Text] [Related]
15. Tec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/Txk.
Readinger JA; Mueller KL; Venegas AM; Horai R; Schwartzberg PL
Immunol Rev; 2009 Mar; 228(1):93-114. PubMed ID: 19290923
[TBL] [Abstract][Full Text] [Related]
16. Interleukin-2-inducible T-cell kinase (ITK) targeting by BMS-509744 does not affect cell viability in T-cell prolymphocytic leukemia (T-PLL).
Dondorf S; Schrader A; Herling M
J Biol Chem; 2015 Apr; 290(16):10568-9. PubMed ID: 25888568
[No Abstract] [Full Text] [Related]
17. Tec kinases regulate TCR-mediated recruitment of signaling molecules and integrin-dependent cell adhesion.
Finkelstein LD; Shimizu Y; Schwartzberg PL
J Immunol; 2005 Nov; 175(9):5923-30. PubMed ID: 16237085
[TBL] [Abstract][Full Text] [Related]
18. Hierarchy of signaling thresholds downstream of the T cell receptor and the Tec kinase ITK.
Gallagher MP; Conley JM; Vangala P; Garber M; Reboldi A; Berg LJ
Proc Natl Acad Sci U S A; 2021 Aug; 118(35):. PubMed ID: 34452995
[TBL] [Abstract][Full Text] [Related]
19. Molecular characteristics of CTA056, a novel interleukin-2-inducible T-cell kinase inhibitor that selectively targets malignant T cells and modulates oncomirs.
Guo W; Liu R; Ono Y; Ma AH; Martinez A; Sanchez E; Wang Y; Huang W; Mazloom A; Li J; Ning J; Maverakis E; Lam KS; Kung HJ
Mol Pharmacol; 2012 Nov; 82(5):938-47. PubMed ID: 22899868
[TBL] [Abstract][Full Text] [Related]
20. A conserved motif in the ITK PH-domain is required for phosphoinositide binding and TCR signaling but dispensable for adaptor protein interactions.
Hirve N; Levytskyy RM; Rigaud S; Guimond DM; Zal T; Sauer K; Tsoukas CD
PLoS One; 2012; 7(9):e45158. PubMed ID: 23028816
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
