These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

141 related articles for article (PubMed ID: 25606977)

  • 1. Anti-HIV Nucleoside Phosphonate GS-9148 and Its Prodrug GS-9131: Scale Up of a 2'-F Modified Cyclic Nucleoside Phosphonate and Synthesis of Selected Amidate Prodrugs.
    Mackman RL
    Curr Protoc Nucleic Acid Chem; 2014 Mar; 56():14.10.1-21. PubMed ID: 25606977
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of GS-9131: Design, synthesis and optimization of amidate prodrugs of the novel nucleoside phosphonate HIV reverse transcriptase (RT) inhibitor GS-9148.
    Mackman RL; Ray AS; Hui HC; Zhang L; Birkus G; Boojamra CG; Desai MC; Douglas JL; Gao Y; Grant D; Laflamme G; Lin KY; Markevitch DY; Mishra R; McDermott M; Pakdaman R; Petrakovsky OV; Vela JE; Cihlar T
    Bioorg Med Chem; 2010 May; 18(10):3606-17. PubMed ID: 20409721
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Design and profiling of GS-9148, a novel nucleotide analog active against nucleoside-resistant variants of human immunodeficiency virus type 1, and its orally bioavailable phosphonoamidate prodrug, GS-9131.
    Cihlar T; Ray AS; Boojamra CG; Zhang L; Hui H; Laflamme G; Vela JE; Grant D; Chen J; Myrick F; White KL; Gao Y; Lin KY; Douglas JL; Parkin NT; Carey A; Pakdaman R; Mackman RL
    Antimicrob Agents Chemother; 2008 Feb; 52(2):655-65. PubMed ID: 18056282
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis and anti-HIV activity of GS-9148 (2'-Fd4AP), a novel nucleoside phosphonate HIV reverse transcriptase inhibitor.
    Boojamra CG; Mackman RL; Markevitch DY; Prasad V; Ray AS; Douglas J; Grant D; Kim CU; Cihlar T
    Bioorg Med Chem Lett; 2008 Feb; 18(3):1120-3. PubMed ID: 18164198
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Intracellular metabolism of the nucleotide prodrug GS-9131, a potent anti-human immunodeficiency virus agent.
    Ray AS; Vela JE; Boojamra CG; Zhang L; Hui H; Callebaut C; Stray K; Lin KY; Gao Y; Mackman RL; Cihlar T
    Antimicrob Agents Chemother; 2008 Feb; 52(2):648-54. PubMed ID: 18056281
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and anti-HIV activity of 2'-fluorine modified nucleoside phosphonates: analogs of GS-9148.
    Mackman RL; Lin KY; Boojamra CG; Hui H; Douglas J; Grant D; Petrakovsky O; Prasad V; Ray AS; Cihlar T
    Bioorg Med Chem Lett; 2008 Feb; 18(3):1116-9. PubMed ID: 18082402
    [TBL] [Abstract][Full Text] [Related]  

  • 7. cycloSal-PMEA and cycloAmb-PMEA: potentially new phosphonate prodrugs based on the cycloSal-pronucleotide approach.
    Meier C; Görbig U; Müller C; Balzarini J
    J Med Chem; 2005 Dec; 48(25):8079-86. PubMed ID: 16335932
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs.
    Luo M; Groaz E; Andrei G; Snoeck R; Kalkeri R; Ptak RG; Hartman T; Buckheit RW; Schols D; De Jonghe S; Herdewijn P
    J Med Chem; 2017 Jul; 60(14):6220-6238. PubMed ID: 28682067
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Practical synthesis, separation, and stereochemical assignment of the PMPA pro-drug GS-7340.
    Chapman H; Kernan M; Prisbe E; Rohloff J; Sparacino M; Terhorst T; Yu R
    Nucleosides Nucleotides Nucleic Acids; 2001; 20(4-7):621-8. PubMed ID: 11563079
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A novel and efficient one-pot synthesis of symmetrical diamide (bis-amidate) prodrugs of acyclic nucleoside phosphonates and evaluation of their biological activities.
    Jansa P; Baszczyňski O; Dračínský M; Votruba I; Zídek Z; Bahador G; Stepan G; Cihlar T; Mackman R; Holý A; Janeba Z
    Eur J Med Chem; 2011 Sep; 46(9):3748-54. PubMed ID: 21664011
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Design, synthesis, and anti-HIV activity of 4'-modified carbocyclic nucleoside phosphonate reverse transcriptase inhibitors.
    Boojamra CG; Parrish JP; Sperandio D; Gao Y; Petrakovsky OV; Lee SK; Markevitch DY; Vela JE; Laflamme G; Chen JM; Ray AS; Barron AC; Sparacino ML; Desai MC; Kim CU; Cihlar T; Mackman RL
    Bioorg Med Chem; 2009 Feb; 17(4):1739-46. PubMed ID: 19179082
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis and biological properties of prodrugs of (S)-3-(adenin-9-yl)-2-(phosphonomethoxy)propanoic acid.
    Kaiser MM; Poštová-Slavětínská L; Dračínský M; Lee YJ; Tian Y; Janeba Z
    Eur J Med Chem; 2016 Jan; 108():374-380. PubMed ID: 26706348
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis of novel 3'-hydroxymethyl 5'-deoxythreosyl phosphonic acid nucleoside analogues as potent antiviral agents.
    Shen GH; Kang L; Kim E; Hong JH
    Nucleosides Nucleotides Nucleic Acids; 2012; 31(10):720-35. PubMed ID: 23067124
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis and Anti-HIV Activity of Guanine Modified Fluorinated Acyclic Nucleoside Phosphonate Derivatives.
    Luo M; Groaz E; De Jonghe S; Schols D; Herdewijn P
    Chem Biodivers; 2019 Feb; 16(2):e1800532. PubMed ID: 30431702
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis, anti-HIV activity, and resistance profile of thymidine phosphonomethoxy nucleosides and their bis-isopropyloxymethylcarbonyl (bisPOC) prodrugs.
    Mackman RL; Zhang L; Prasad V; Boojamra CG; Douglas J; Grant D; Hui H; Kim CU; Laflamme G; Parrish J; Stoycheva AD; Swaminathan S; Wang K; Cihlar T
    Bioorg Med Chem; 2007 Aug; 15(16):5519-28. PubMed ID: 17562366
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Bisamidate Prodrugs of 2-Substituted 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA, adefovir) as Selective Inhibitors of Adenylate Cyclase Toxin from Bordetella pertussis.
    Česnek M; Jansa P; Šmídková M; Mertlíková-Kaiserová H; Dračínský M; Brust TF; Pávek P; Trejtnar F; Watts VJ; Janeba Z
    ChemMedChem; 2015 Aug; 10(8):1351-64. PubMed ID: 26136378
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis and anti-HIV evaluation of new acyclic phosphonate nucleotide analogues and their bis(SATE) derivatives.
    Li H; Hong JH
    Nucleosides Nucleotides Nucleic Acids; 2010 Aug; 29(8):581-90. PubMed ID: 20661812
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Amidate Prodrugs of Deoxythreosyl Nucleoside Phosphonates as Dual Inhibitors of HIV and HBV Replication.
    Liu C; Dumbre SG; Pannecouque C; Huang C; Ptak RG; Murray MG; De Jonghe S; Herdewijn P
    J Med Chem; 2016 Oct; 59(20):9513-9531. PubMed ID: 27748590
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and anti-HIV activity of (-)-beta-D-(2R,4R)-1,3-dioxolane-2,6-diamino purine (DAPD) (amdoxovir) and (-)-beta-D-(2R,4R)-1,3-dioxolane guanosine (DXG) prodrugs.
    Narayanasamy J; Pullagurla MR; Sharon A; Wang J; Schinazi RF; Chu CK
    Antiviral Res; 2007 Sep; 75(3):198-209. PubMed ID: 17532483
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis and Evaluation of Prodrugs of α-Carboxy Nucleoside Phosphonates.
    Ford A; Mullins ND; Balzarini J; Maguire AR
    J Org Chem; 2022 Nov; 87(21):14793-14808. PubMed ID: 36283025
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.