BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

386 related articles for article (PubMed ID: 25609585)

  • 1. The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors.
    Zingg D; Debbache J; Schaefer SM; Tuncer E; Frommel SC; Cheng P; Arenas-Ramirez N; Haeusel J; Zhang Y; Bonalli M; McCabe MT; Creasy CL; Levesque MP; Boyman O; Santoro R; Shakhova O; Dummer R; Sommer L
    Nat Commun; 2015 Jan; 6():6051. PubMed ID: 25609585
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Sox4 is a master regulator of epithelial-mesenchymal transition by controlling Ezh2 expression and epigenetic reprogramming.
    Tiwari N; Tiwari VK; Waldmeier L; Balwierz PJ; Arnold P; Pachkov M; Meyer-Schaller N; Schübeler D; van Nimwegen E; Christofori G
    Cancer Cell; 2013 Jun; 23(6):768-83. PubMed ID: 23764001
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Targeting activating mutations of EZH2 leads to potent cell growth inhibition in human melanoma by derepression of tumor suppressor genes.
    Tiffen JC; Gunatilake D; Gallagher SJ; Gowrishankar K; Heinemann A; Cullinane C; Dutton-Regester K; Pupo GM; Strbenac D; Yang JY; Madore J; Mann GJ; Hayward NK; McArthur GA; Filipp FV; Hersey P
    Oncotarget; 2015 Sep; 6(29):27023-36. PubMed ID: 26304929
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Epigenetic reprogramming by tumor-derived EZH2 gain-of-function mutations promotes aggressive 3D cell morphologies and enhances melanoma tumor growth.
    Barsotti AM; Ryskin M; Zhong W; Zhang WG; Giannakou A; Loreth C; Diesl V; Follettie M; Golas J; Lee M; Nichols T; Fan C; Li G; Dann S; Fantin VR; Arndt K; Verhelle D; Rollins RA
    Oncotarget; 2015 Feb; 6(5):2928-38. PubMed ID: 25671303
    [TBL] [Abstract][Full Text] [Related]  

  • 5. EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation.
    Zingg D; Debbache J; Peña-Hernández R; Antunes AT; Schaefer SM; Cheng PF; Zimmerli D; Haeusel J; Calçada RR; Tuncer E; Zhang Y; Bossart R; Wong KK; Basler K; Dummer R; Santoro R; Levesque MP; Sommer L
    Cancer Cell; 2018 Jul; 34(1):69-84.e14. PubMed ID: 30008323
    [TBL] [Abstract][Full Text] [Related]  

  • 6. EZH2: an emerging role in melanoma biology and strategies for targeted therapy.
    Tiffen J; Gallagher SJ; Hersey P
    Pigment Cell Melanoma Res; 2015 Jan; 28(1):21-30. PubMed ID: 24912396
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The polycomb group protein enhancer of zeste 2 is a novel therapeutic target for cervical cancer.
    Ding M; Zhang H; Li Z; Wang C; Chen J; Shi L; Xu D; Gao Y
    Clin Exp Pharmacol Physiol; 2015 May; 42(5):458-64. PubMed ID: 25739318
    [TBL] [Abstract][Full Text] [Related]  

  • 8. EZH2 is regulated by ERK/AKT and targets integrin alpha2 gene to control Epithelial-Mesenchymal Transition and anoikis in colon cancer cells.
    Ferraro A; Mourtzoukou D; Kosmidou V; Avlonitis S; Kontogeorgos G; Zografos G; Pintzas A
    Int J Biochem Cell Biol; 2013 Feb; 45(2):243-54. PubMed ID: 23116973
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Overexpression of EZH2 in conjunctival melanoma offers a new therapeutic target.
    Cao J; Pontes KC; Heijkants RC; Brouwer NJ; Groenewoud A; Jordanova ES; Marinkovic M; van Duinen S; Teunisse AF; Verdijk RM; Snaar-Jagalska E; Jochemsen AG; Jager MJ
    J Pathol; 2018 Aug; 245(4):433-444. PubMed ID: 29732557
    [TBL] [Abstract][Full Text] [Related]  

  • 10. MicroRNA-101 inhibits human hepatocellular carcinoma progression through EZH2 downregulation and increased cytostatic drug sensitivity.
    Xu L; Beckebaum S; Iacob S; Wu G; Kaiser GM; Radtke A; Liu C; Kabar I; Schmidt HH; Zhang X; Lu M; Cicinnati VR
    J Hepatol; 2014 Mar; 60(3):590-8. PubMed ID: 24211739
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Overexpression of enhancer of zests homolog 2 in lymphoma.
    Guo SQ; Zhang YZ
    Chin Med J (Engl); 2012 Oct; 125(20):3735-9. PubMed ID: 23075734
    [TBL] [Abstract][Full Text] [Related]  

  • 12. EZH2 blockade by RNA interference inhibits growth of ovarian cancer by facilitating re-expression of p21(waf1/cip1) and by inhibiting mutant p53.
    Seward S; Semaan A; Qazi AM; Gruzdyn OV; Chamala S; Bryant CC; Kumar S; Cameron D; Sethi S; Ali-Fehmi R; Morris R; Bouwman DL; Munkarah AR; Weaver DW; Gruber SA; Batchu RB
    Cancer Lett; 2013 Aug; 336(1):53-60. PubMed ID: 23603558
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Reciprocal regulation of amino acid import and epigenetic state through Lat1 and EZH2.
    Dann SG; Ryskin M; Barsotti AM; Golas J; Shi C; Miranda M; Hosselet C; Lemon L; Lucas J; Karnoub M; Wang F; Myers JS; Garza SJ; Follettie MT; Geles KG; Klippel A; Rollins RA; Fantin VR
    EMBO J; 2015 Jul; 34(13):1773-85. PubMed ID: 25979827
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Epigenetic modification in gliomas: role of the histone methyltransferase EZH2.
    Bian EB; Li J; He XJ; Zong G; Jiang T; Li J; Zhao B
    Expert Opin Ther Targets; 2014 Oct; 18(10):1197-206. PubMed ID: 25046371
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Epigenetic modifications in cutaneous malignant melanoma: EZH2, H3K4me2, and H3K27me3 immunohistochemical expression is enhanced at the invasion front of the tumor.
    Kampilafkos P; Melachrinou M; Kefalopoulou Z; Lakoumentas J; Sotiropoulou-Bonikou G
    Am J Dermatopathol; 2015 Feb; 37(2):138-44. PubMed ID: 25614949
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Enhancer of zeste homolog 2 silences microRNA-218 in human pancreatic ductal adenocarcinoma cells by inducing formation of heterochromatin.
    Li CH; To KF; Tong JH; Xiao Z; Xia T; Lai PB; Chow SC; Zhu YX; Chan SL; Marquez VE; Chen Y
    Gastroenterology; 2013 May; 144(5):1086-1097.e9. PubMed ID: 23395645
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Enhancer of zeste homolog 2 expression is associated with metastasis and adverse clinical outcome in clear cell renal cell carcinoma: a comparative study and review of the literature.
    Xu B; Abourbih S; Sircar K; Kassouf W; Mansure JJ; Aprikian A; Tanguay S; Brimo F
    Arch Pathol Lab Med; 2013 Oct; 137(10):1326-36. PubMed ID: 24079759
    [TBL] [Abstract][Full Text] [Related]  

  • 18. MiR-101 inhibits melanoma cell invasion and proliferation by targeting MITF and EZH2.
    Luo C; Merz PR; Chen Y; Dickes E; Pscherer A; Schadendorf D; Eichmüller SB
    Cancer Lett; 2013 Dec; 341(2):240-7. PubMed ID: 23962556
    [TBL] [Abstract][Full Text] [Related]  

  • 19. AP-2α-Mediated Activation of E2F and EZH2 Drives Melanoma Metastasis.
    White JR; Thompson DT; Koch KE; Kiriazov BS; Beck AC; van der Heide DM; Grimm BG; Kulak MV; Weigel RJ
    Cancer Res; 2021 Sep; 81(17):4455-4470. PubMed ID: 34210752
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Somatic Copy Number Amplification and Hyperactivating Somatic Mutations of EZH2 Correlate With DNA Methylation and Drive Epigenetic Silencing of Genes Involved in Tumor Suppression and Immune Responses in Melanoma.
    Tiffen J; Wilson S; Gallagher SJ; Hersey P; Filipp FV
    Neoplasia; 2016 Feb; 18(2):121-32. PubMed ID: 26936398
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 20.