These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

320 related articles for article (PubMed ID: 25612170)

  • 1. Cytotoxicity of luteolin in primary rat hepatocytes: the role of CYP3A-mediated ortho-benzoquinone metabolite formation and glutathione depletion.
    Shi F; Zhao P; Li X; Pan H; Ma S; Ding L
    J Appl Toxicol; 2015 Nov; 35(11):1372-80. PubMed ID: 25612170
    [TBL] [Abstract][Full Text] [Related]  

  • 2. CYP3A Activation and Glutathione Depletion Aggravate Emodin-Induced Liver Injury.
    Jiang LL; Jiang Y; Zhao DS; Fan YX; Yu Q; Li P; Li HJ
    Chem Res Toxicol; 2018 Oct; 31(10):1052-1060. PubMed ID: 30203651
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Acetaminophen analog N-acetyl-m-aminophenol, but not its reactive metabolite, N-acetyl-p-benzoquinone imine induces CYP3A activity via inhibition of protein degradation.
    Santoh M; Sanoh S; Ohtsuki Y; Ejiri Y; Kotake Y; Ohta S
    Biochem Biophys Res Commun; 2017 May; 486(3):639-644. PubMed ID: 28341123
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Cytotoxicity of safrole in HepaRG cells: studies on the role of CYP1A2-mediated ortho-quinone metabolic activation.
    Hu L; Wu F; He J; Zhong L; Song Y; Shao H
    Xenobiotica; 2019 Dec; 49(12):1504-1515. PubMed ID: 30865484
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Demethylation of neferine in human liver microsomes and formation of quinone methide metabolites mediated by CYP3A4 accentuates its cytotoxicity.
    Shen Q; Zuo M; Ma L; Tian Y; Wang L; Jiang H; Zhou Q; Zhou H; Yu L; Zeng S
    Chem Biol Interact; 2014 Dec; 224():89-99. PubMed ID: 25451576
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Carbamazepine-Induced Liver Injury Requires CYP3A-Mediated Metabolism and Glutathione Depletion in Rats.
    Iida A; Sasaki E; Yano A; Tsuneyama K; Fukami T; Nakajima M; Yokoi T
    Drug Metab Dispos; 2015 Jul; 43(7):958-68. PubMed ID: 25870103
    [TBL] [Abstract][Full Text] [Related]  

  • 7. In vitro metabolism of BIIB021, an inhibitor of heat shock protein 90, in liver microsomes and hepatocytes of rats, dogs, and humans and recombinant human cytochrome P450 isoforms.
    Xu L; Woodward C; Khan S; Prakash C
    Drug Metab Dispos; 2012 Apr; 40(4):680-93. PubMed ID: 22217465
    [TBL] [Abstract][Full Text] [Related]  

  • 8. CYP3A-mediated apoptosis of dauricine in cultured human bronchial epithelial cells and in lungs of CD-1 mice.
    Jin H; Shen S; Chen X; Zhong D; Zheng J
    Toxicol Appl Pharmacol; 2012 Jun; 261(3):248-54. PubMed ID: 22521607
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Role of CYP3A in regulating hepatic clearance and hepatotoxicity of triptolide in rat liver microsomes and sandwich-cultured hepatocytes.
    Shen G; Zhuang X; Xiao W; Kong L; Tan Y; Li H
    Food Chem Toxicol; 2014 Sep; 71():90-6. PubMed ID: 24910460
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Reactive metabolite activation by CYP2C19-mediated rhein hepatotoxicity.
    He LN; Yang AH; Cui TY; Zhai YR; Zhang FL; Chen JX; Jin CH; Fan YW; Wu ZJ; Wang LL; He X
    Xenobiotica; 2015 Apr; 45(4):361-72. PubMed ID: 25815638
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Evaluating the Role of Drug Metabolism and Reactive Intermediates in Trazodone-Induced Cytotoxicity toward Freshly-Isolated Rat Hepatocytes.
    Najibi A; Heidari R; Zarifi J; Jamshidzadeh A; Firoozabadi N; Niknahad H
    Drug Res (Stuttg); 2016 Nov; 66(11):592-596. PubMed ID: 27643409
    [No Abstract]   [Full Text] [Related]  

  • 12. Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites.
    Tang W; Stearns RA; Bandiera SM; Zhang Y; Raab C; Braun MP; Dean DC; Pang J; Leung KH; Doss GA; Strauss JR; Kwei GY; Rushmore TH; Chiu SH; Baillie TA
    Drug Metab Dispos; 1999 Mar; 27(3):365-72. PubMed ID: 10064567
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Studies on the role of metabolic activation in tyrosine kinase inhibitor-dependent hepatotoxicity: induction of CYP3A4 enhances the cytotoxicity of lapatinib in HepaRG cells.
    Hardy KD; Wahlin MD; Papageorgiou I; Unadkat JD; Rettie AE; Nelson SD
    Drug Metab Dispos; 2014 Jan; 42(1):162-71. PubMed ID: 24191259
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Metabolic-induced cytotoxicity of diosbulbin B in CYP3A4-expressing cells.
    Jiang JZ; Yang BH; Ji LL; Yang L; Mao YC; Hu ZH; Wang ZT; Wang CH
    Toxicol In Vitro; 2017 Feb; 38():59-66. PubMed ID: 27836570
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Mechanism of Action of Panaxytriol on Midazolam 1'-Hydroxylation and 4-Hydroxylation Mediated by CYP3A in Liver Microsomes and Rat Primary Hepatocytes.
    He F; Zhang W; Zeng C; Xia C; Xiong Y; Zhang H; Huang S; Liu M
    Biol Pharm Bull; 2015; 38(10):1470-7. PubMed ID: 26424012
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Glutathione depletion by valproic acid in sandwich-cultured rat hepatocytes: Role of biotransformation and temporal relationship with onset of toxicity.
    Kiang TK; Teng XW; Surendradoss J; Karagiozov S; Abbott FS; Chang TK
    Toxicol Appl Pharmacol; 2011 May; 252(3):318-24. PubMed ID: 21397622
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Bioactivation of sitaxentan in liver microsomes, hepatocytes, and expressed human P450s with characterization of the glutathione conjugate by liquid chromatography tandem mass spectrometry.
    Erve JC; Gauby S; Maynard JW; Svensson MA; Tonn G; Quinn KP
    Chem Res Toxicol; 2013 Jun; 26(6):926-36. PubMed ID: 23721565
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Metabolic Activation and Cytotoxicity of Gramine Mediated by CYP3A in Rats.
    Gao X; Hu Z; Wang Y; Zhao G; Shen Y; Zhou H; Liao Y; Li W; Peng Y; Zheng J
    J Agric Food Chem; 2024 May; 72(19):10897-10908. PubMed ID: 38691522
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Cytotoxicity of unsaturated metabolites of valproic acid and protection by vitamins C and E in glutathione-depleted rat hepatocytes.
    Jurima-Romet M; Abbott FS; Tang W; Huang HS; Whitehouse LW
    Toxicology; 1996 Aug; 112(1):69-85. PubMed ID: 8792850
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cytochrome p450-mediated metabolic activation of diosbulbin B.
    Lin D; Li C; Peng Y; Gao H; Zheng J
    Drug Metab Dispos; 2014 Oct; 42(10):1727-36. PubMed ID: 25024403
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.