BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

262 related articles for article (PubMed ID: 25646473)

  • 1. Overlapping hotspots in CDRs are critical sites for V region diversification.
    Wei L; Chahwan R; Wang S; Wang X; Pham PT; Goodman MF; Bergman A; Scharff MD; MacCarthy T
    Proc Natl Acad Sci U S A; 2015 Feb; 112(7):E728-37. PubMed ID: 25646473
    [TBL] [Abstract][Full Text] [Related]  

  • 2. AID Overlapping and Polη Hotspots Are Key Features of Evolutionary Variation Within the Human Antibody Heavy Chain (IGHV) Genes.
    Tang C; Bagnara D; Chiorazzi N; Scharff MD; MacCarthy T
    Front Immunol; 2020; 11():788. PubMed ID: 32425948
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Recombinase-mediated cassette exchange as a novel method to study somatic hypermutation in Ramos cells.
    Baughn LB; Kalis SL; MacCarthy T; Wei L; Fan M; Bergman A; Scharff MD
    mBio; 2011; 2(5):. PubMed ID: 21990614
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Correlations in Somatic Hypermutation Between Sites in IGHV Genes Can Be Explained by Interactions Between AID and/or Polη Hotspots.
    Krantsevich A; Tang C; MacCarthy T
    Front Immunol; 2020; 11():618409. PubMed ID: 33603748
    [TBL] [Abstract][Full Text] [Related]  

  • 5. AID-RNA polymerase II transcription-dependent deamination of IgV DNA.
    Pham P; Malik S; Mak C; Calabrese PC; Roeder RG; Goodman MF
    Nucleic Acids Res; 2019 Nov; 47(20):10815-10829. PubMed ID: 31566237
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Analysis of 6912 unselected somatic hypermutations in human VDJ rearrangements reveals lack of strand specificity and correlation between phase II substitution rates and distance to the nearest 3' activation-induced cytidine deaminase target.
    Ohm-Laursen L; Barington T
    J Immunol; 2007 Apr; 178(7):4322-34. PubMed ID: 17371989
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Interpretable deep learning reveals the role of an E-box motif in suppressing somatic hypermutation of AGCT motifs within human immunoglobulin variable regions.
    Tambe A; MacCarthy T; Pavri R
    Front Immunol; 2024; 15():1407470. PubMed ID: 38863710
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Characterization of DNA G-Quadruplex Structures in Human Immunoglobulin Heavy Variable (IGHV) Genes.
    Tang C; MacCarthy T
    Front Immunol; 2021; 12():671944. PubMed ID: 34040612
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The targeting of somatic hypermutation.
    Jolly CJ; Wagner SD; Rada C; Klix N; Milstein C; Neuberger MS
    Semin Immunol; 1996 Jun; 8(3):159-68. PubMed ID: 8738915
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Immunoglobulin diversification in B cell malignancies: internal splicing of heavy chain variable region as a by-product of somatic hypermutation.
    Bende RJ; Aarts WM; Pals ST; van Noesel CJ
    Leukemia; 2002 Apr; 16(4):636-44. PubMed ID: 11960344
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Mesoscale DNA feature in antibody-coding sequence facilitates somatic hypermutation.
    Wang Y; Zhang S; Yang X; Hwang JK; Zhan C; Lian C; Wang C; Gui T; Wang B; Xie X; Dai P; Zhang L; Tian Y; Zhang H; Han C; Cai Y; Hao Q; Ye X; Liu X; Liu J; Cao Z; Huang S; Song J; Pan-Hammarström Q; Zhao Y; Alt FW; Zheng X; Da LT; Yeap LS; Meng FL
    Cell; 2023 May; 186(10):2193-2207.e19. PubMed ID: 37098343
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID.
    Wang M; Rada C; Neuberger MS
    J Exp Med; 2010 Jan; 207(1):141-53. PubMed ID: 20048284
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Integrity of immunoglobulin variable regions is supported by GANP during AID-induced somatic hypermutation in germinal center B cells.
    Eid MMA; Shimoda M; Singh SK; Almofty SA; Pham P; Goodman MF; Maeda K; Sakaguchi N
    Int Immunol; 2017 May; 29(5):211-220. PubMed ID: 28541550
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Sequence intrinsic somatic mutation mechanisms contribute to affinity maturation of VRC01-class HIV-1 broadly neutralizing antibodies.
    Hwang JK; Wang C; Du Z; Meyers RM; Kepler TB; Neuberg D; Kwong PD; Mascola JR; Joyce MG; Bonsignori M; Haynes BF; Yeap LS; Alt FW
    Proc Natl Acad Sci U S A; 2017 Aug; 114(32):8614-8619. PubMed ID: 28747530
    [TBL] [Abstract][Full Text] [Related]  

  • 15. B cell variable genes have evolved their codon usage to focus the targeted patterns of somatic mutation on the complementarity determining regions.
    Saini J; Hershberg U
    Mol Immunol; 2015 May; 65(1):157-67. PubMed ID: 25660968
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Somatic hypermutation targeting to intrinsic hotspots of immunoglobulin genes in follicular lymphoma and multiple myeloma.
    Belessi C; Stamatopoulos K; Stavroyianni N; Zoi K; Papadaki T; Kosmas C
    Leukemia; 2001 Nov; 15(11):1772-8. PubMed ID: 11681420
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas.
    Martin A; Bardwell PD; Woo CJ; Fan M; Shulman MJ; Scharff MD
    Nature; 2002 Feb; 415(6873):802-6. PubMed ID: 11823785
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Large-scale analysis of somatic hypermutations in antibodies reveals which structural regions, positions and amino acids are modified to improve affinity.
    Burkovitz A; Sela-Culang I; Ofran Y
    FEBS J; 2014 Jan; 281(1):306-19. PubMed ID: 24279419
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Clonal instability of V region hypermutation in the Ramos Burkitt's lymphoma cell line.
    Zhang W; Bardwell PD; Woo CJ; Poltoratsky V; Scharff MD; Martin A
    Int Immunol; 2001 Sep; 13(9):1175-84. PubMed ID: 11526098
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Targets of somatic hypermutation within immunoglobulin light chain genes in zebrafish.
    Marianes AE; Zimmerman AM
    Immunology; 2011 Feb; 132(2):240-55. PubMed ID: 21070232
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.