These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

122 related articles for article (PubMed ID: 25654496)

  • 1. Effect of cholesterol on the structure of membrane-attached cytochrome P450 3A4.
    Navrátilová V; Paloncýová M; Kajšová M; Berka K; Otyepka M
    J Chem Inf Model; 2015 Mar; 55(3):628-35. PubMed ID: 25654496
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Membrane-embedded substrate recognition by cytochrome P450 3A4.
    Hackett JC
    J Biol Chem; 2018 Mar; 293(11):4037-4046. PubMed ID: 29382727
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Effect of Lipid Charge on Membrane Immersion of Cytochrome P450 3A4.
    Navrátilová V; Paloncýová M; Berka K; Otyepka M
    J Phys Chem B; 2016 Nov; 120(43):11205-11213. PubMed ID: 27723344
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Small-angle scattering determination of the shape and localization of human cytochrome P450 embedded in a phospholipid nanodisc environment.
    Skar-Gislinge N; Kynde SA; Denisov IG; Ye X; Lenov I; Sligar SG; Arleth L
    Acta Crystallogr D Biol Crystallogr; 2015 Dec; 71(Pt 12):2412-21. PubMed ID: 26627649
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Flexibility of human cytochrome P450 enzymes: molecular dynamics and spectroscopy reveal important function-related variations.
    Hendrychová T; Anzenbacherová E; Hudeček J; Skopalík J; Lange R; Hildebrandt P; Otyepka M; Anzenbacher P
    Biochim Biophys Acta; 2011 Jan; 1814(1):58-68. PubMed ID: 20656072
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Influence of High pH and Cholesterol on Single Arginine-Containing Transmembrane Peptide Helices.
    Thibado JK; Martfeld AN; Greathouse DV; Koeppe RE
    Biochemistry; 2016 Nov; 55(45):6337-6343. PubMed ID: 27782382
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Role of Enzyme Flexibility in Ligand Access and Egress to Active Site: Bias-Exchange Metadynamics Study of 1,3,7-Trimethyluric Acid in Cytochrome P450 3A4.
    Paloncýová M; Navrátilová V; Berka K; Laio A; Otyepka M
    J Chem Theory Comput; 2016 Apr; 12(4):2101-9. PubMed ID: 26967371
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Behavior of human cytochromes P450 on lipid membranes.
    Berka K; Paloncýová M; Anzenbacher P; Otyepka M
    J Phys Chem B; 2013 Oct; 117(39):11556-64. PubMed ID: 23987570
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Concurrent cooperativity and substrate inhibition in the epoxidation of carbamazepine by cytochrome P450 3A4 active site mutants inspired by molecular dynamics simulations.
    Müller CS; Knehans T; Davydov DR; Bounds PL; von Mandach U; Halpert JR; Caflisch A; Koppenol WH
    Biochemistry; 2015 Jan; 54(3):711-21. PubMed ID: 25545162
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Evaluation of membrane models and their composition for islet amyloid polypeptide-membrane aggregation.
    Caillon L; Lequin O; Khemtémourian L
    Biochim Biophys Acta; 2013 Sep; 1828(9):2091-8. PubMed ID: 23707907
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Structural basis for regiospecific midazolam oxidation by human cytochrome P450 3A4.
    Sevrioukova IF; Poulos TL
    Proc Natl Acad Sci U S A; 2017 Jan; 114(3):486-491. PubMed ID: 28031486
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Characterizing the membrane-bound state of cytochrome P450 3A4: structure, depth of insertion, and orientation.
    Baylon JL; Lenov IL; Sligar SG; Tajkhorshid E
    J Am Chem Soc; 2013 Jun; 135(23):8542-51. PubMed ID: 23697766
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Membrane Fluidity Modulates Thermal Stability and Ligand Binding of Cytochrome P4503A4 in Lipid Nanodiscs.
    McClary WD; Sumida JP; Scian M; Paço L; Atkins WM
    Biochemistry; 2016 Nov; 55(45):6258-6268. PubMed ID: 27782404
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Computational Investigation of Ligand Binding to the Peripheral Site in CYP3A4: Conformational Dynamics and Inhibitor Discovery.
    Du H; Li J; Cai Y; Zhang H; Liu G; Tang Y; Li W
    J Chem Inf Model; 2017 Mar; 57(3):616-626. PubMed ID: 28221037
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Influence of cytochrome P450 3A4 and membrane lipid composition on doxorubicin activity.
    Dos Santos KF; Materón EM; Oliveira ON
    Colloids Surf B Biointerfaces; 2022 Dec; 220():112886. PubMed ID: 36183636
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structural Dynamics of Cytochrome P450 3A4 in the Presence of Substrates and Cytochrome P450 Reductase.
    Ducharme J; Sevrioukova IF; Thibodeaux CJ; Auclair K
    Biochemistry; 2021 Jul; 60(28):2259-2271. PubMed ID: 34196520
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Membrane properties induced by anionic phospholipids and phosphatidylethanolamine are critical for the membrane binding and catalytic activity of human cytochrome P450 3A4.
    Kim KH; Ahn T; Yun CH
    Biochemistry; 2003 Dec; 42(51):15377-87. PubMed ID: 14690448
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Membrane Interactions, Ligand-Dependent Dynamics, and Stability of Cytochrome P4503A4 in Lipid Nanodiscs.
    Treuheit NA; Redhair M; Kwon H; McClary WD; Guttman M; Sumida JP; Atkins WM
    Biochemistry; 2016 Feb; 55(7):1058-69. PubMed ID: 26814638
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The Cytochrome P450 3A4 has three Major Conformations: New Clues to Drug Recognition by this Promiscuous Enzyme.
    Benkaidali L; André F; Moroy G; Tangour B; Maurel F; Petitjean M
    Mol Inform; 2017 Oct; 36(10):. PubMed ID: 28685969
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A multiscale approach to modelling drug metabolism by membrane-bound cytochrome P450 enzymes.
    Lonsdale R; Rouse SL; Sansom MS; Mulholland AJ
    PLoS Comput Biol; 2014 Jul; 10(7):e1003714. PubMed ID: 25033460
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.