BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

137 related articles for article (PubMed ID: 25658737)

  • 1. [Stimulation of the antiviral innate immune response by pyrimidine biosynthesis inhibitors: a surprise of phenotypic screening].
    Vidalain PO; Lucas-Hourani M; Helynck O; Tangy F; Munier-Lehmann H
    Med Sci (Paris); 2015 Jan; 31(1):98-104. PubMed ID: 25658737
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Assessment of drug candidates for broad-spectrum antiviral therapy targeting cellular pyrimidine biosynthesis.
    Marschall M; Niemann I; Kosulin K; Bootz A; Wagner S; Dobner T; Herz T; Kramer B; Leban J; Vitt D; Stamminger T; Hutterer C; Strobl S
    Antiviral Res; 2013 Dec; 100(3):640-8. PubMed ID: 24149002
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Inhibiting pyrimidine biosynthesis impairs Ebola virus replication through depletion of nucleoside pools and activation of innate immune responses.
    Luthra P; Naidoo J; Pietzsch CA; De S; Khadka S; Anantpadma M; Williams CG; Edwards MR; Davey RA; Bukreyev A; Ready JM; Basler CF
    Antiviral Res; 2018 Oct; 158():288-302. PubMed ID: 30144461
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Original Chemical Series of Pyrimidine Biosynthesis Inhibitors That Boost the Antiviral Interferon Response.
    Lucas-Hourani M; Dauzonne D; Munier-Lehmann H; Khiar S; Nisole S; Dairou J; Helynck O; Afonso PV; Tangy F; Vidalain PO
    Antimicrob Agents Chemother; 2017 Oct; 61(10):. PubMed ID: 28807907
    [No Abstract]   [Full Text] [Related]  

  • 5. Broad-spectrum inhibition of common respiratory RNA viruses by a pyrimidine synthesis inhibitor with involvement of the host antiviral response.
    Cheung NN; Lai KK; Dai J; Kok KH; Chen H; Chan KH; Yuen KY; Kao RYT
    J Gen Virol; 2017 May; 98(5):946-954. PubMed ID: 28555543
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Inhibition of pyrimidine biosynthesis pathway suppresses viral growth through innate immunity.
    Lucas-Hourani M; Dauzonne D; Jorda P; Cousin G; Lupan A; Helynck O; Caignard G; Janvier G; André-Leroux G; Khiar S; Escriou N; Desprès P; Jacob Y; Munier-Lehmann H; Tangy F; Vidalain PO
    PLoS Pathog; 2013; 9(10):e1003678. PubMed ID: 24098125
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Original 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH).
    Munier-Lehmann H; Lucas-Hourani M; Guillou S; Helynck O; Zanghi G; Noel A; Tangy F; Vidalain PO; Janin YL
    J Med Chem; 2015 Jan; 58(2):860-77. PubMed ID: 25558988
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Inhibition of dengue virus through suppression of host pyrimidine biosynthesis.
    Wang QY; Bushell S; Qing M; Xu HY; Bonavia A; Nunes S; Zhou J; Poh MK; Florez de Sessions P; Niyomrattanakit P; Dong H; Hoffmaster K; Goh A; Nilar S; Schul W; Jones S; Kramer L; Compton T; Shi PY
    J Virol; 2011 Jul; 85(13):6548-56. PubMed ID: 21507975
    [TBL] [Abstract][Full Text] [Related]  

  • 9. High-throughput screening for broad-spectrum chemical inhibitors of RNA viruses.
    Lucas-Hourani M; Munier-Lehmann H; Helynck O; Komarova A; Desprès P; Tangy F; Vidalain PO
    J Vis Exp; 2014 May; (87):. PubMed ID: 24838008
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Novel Dihydroorotate Dehydrogenase Inhibitors with Potent Interferon-Independent Antiviral Activity against Mammarenaviruses In Vitro.
    Kim YJ; Cubitt B; Cai Y; Kuhn JH; Vitt D; Kohlhof H; de la Torre JC
    Viruses; 2020 Jul; 12(8):. PubMed ID: 32751087
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Broad-spectrum antiviral that interferes with de novo pyrimidine biosynthesis.
    Hoffmann HH; Kunz A; Simon VA; Palese P; Shaw ML
    Proc Natl Acad Sci U S A; 2011 Apr; 108(14):5777-82. PubMed ID: 21436031
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Potent antiviral activity of brequinar against the emerging Cantagalo virus in cell culture.
    Schnellrath LC; Damaso CR
    Int J Antimicrob Agents; 2011 Nov; 38(5):435-41. PubMed ID: 21840180
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Novel AR-12 derivatives, P12-23 and P12-34, inhibit flavivirus replication by blocking host de novo pyrimidine biosynthesis.
    Yang CF; Gopula B; Liang JJ; Li JK; Chen SY; Lee YL; Chen CS; Lin YL
    Emerg Microbes Infect; 2018 Nov; 7(1):187. PubMed ID: 30459406
    [TBL] [Abstract][Full Text] [Related]  

  • 14. D282, a non-nucleoside inhibitor of influenza virus infection that interferes with de novo pyrimidine biosynthesis.
    Smee DF; Hurst BL; Day CW
    Antivir Chem Chemother; 2012 Aug; 22(6):263-72. PubMed ID: 22516927
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Human pyrimidine nucleotide biosynthesis as a target for antiviral chemotherapy.
    Okesli A; Khosla C; Bassik MC
    Curr Opin Biotechnol; 2017 Dec; 48():127-134. PubMed ID: 28458037
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Respiratory syncytial virus infection in macaques is not suppressed by intranasal sprays of pyrimidine biosynthesis inhibitors.
    Grandin C; Hourani ML; Janin YL; Dauzonne D; Munier-Lehmann H; Paturet A; Taborik F; Vabret A; Contamin H; Tangy F; Vidalain PO
    Antiviral Res; 2016 Jan; 125():58-62. PubMed ID: 26593978
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH).
    Lucas-Hourani M; Munier-Lehmann H; El Mazouni F; Malmquist NA; Harpon J; Coutant EP; Guillou S; Helynck O; Noel A; Scherf A; Phillips MA; Tangy F; Vidalain PO; Janin YL
    J Med Chem; 2015 Jul; 58(14):5579-98. PubMed ID: 26079043
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Functional expression of human dihydroorotate dehydrogenase (DHODH) in pyr4 mutants of ustilago maydis allows target validation of DHODH inhibitors in vivo.
    Zameitat E; Freymark G; Dietz CD; Löffler M; Bölker M
    Appl Environ Microbiol; 2007 May; 73(10):3371-9. PubMed ID: 17369345
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibition of the mitochondrial pyrimidine biosynthesis enzyme dihydroorotate dehydrogenase by doxorubicin and brequinar sensitizes cancer cells to TRAIL-induced apoptosis.
    He T; Haapa-Paananen S; Kaminskyy VO; Kohonen P; Fey V; Zhivotovsky B; Kallioniemi O; Perälä M
    Oncogene; 2014 Jul; 33(27):3538-49. PubMed ID: 24013224
    [TBL] [Abstract][Full Text] [Related]  

  • 20. High throughput screening for small molecule enhancers of the interferon signaling pathway to drive next-generation antiviral drug discovery.
    Patel DA; Patel AC; Nolan WC; Zhang Y; Holtzman MJ
    PLoS One; 2012; 7(5):e36594. PubMed ID: 22574190
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.