These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

320 related articles for article (PubMed ID: 25667954)

  • 1. Discovery of 4'-chloromethyl-2'-deoxy-3',5'-di-O-isobutyryl-2'-fluorocytidine (ALS-8176), a first-in-class RSV polymerase inhibitor for treatment of human respiratory syncytial virus infection.
    Wang G; Deval J; Hong J; Dyatkina N; Prhavc M; Taylor J; Fung A; Jin Z; Stevens SK; Serebryany V; Liu J; Zhang Q; Tam Y; Chanda SM; Smith DB; Symons JA; Blatt LM; Beigelman L
    J Med Chem; 2015 Feb; 58(4):1862-78. PubMed ID: 25667954
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Activation Pathway of a Nucleoside Analog Inhibiting Respiratory Syncytial Virus Polymerase.
    Jordan PC; Stevens SK; Tam Y; Pemberton RP; Chaudhuri S; Stoycheva AD; Dyatkina N; Wang G; Symons JA; Deval J; Beigelman L
    ACS Chem Biol; 2017 Jan; 12(1):83-91. PubMed ID: 28103684
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate.
    Deval J; Hong J; Wang G; Taylor J; Smith LK; Fung A; Stevens SK; Liu H; Jin Z; Dyatkina N; Prhavc M; Stoycheva AD; Serebryany V; Liu J; Smith DB; Tam Y; Zhang Q; Moore ML; Fearns R; Chanda SM; Blatt LM; Symons JA; Beigelman L
    PLoS Pathog; 2015 Jun; 11(6):e1004995. PubMed ID: 26098424
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of a potent respiratory syncytial virus RNA polymerase inhibitor.
    Xiong H; Foulk M; Aschenbrenner L; Fan J; Tiong-Yip CL; Johnson KD; Moustakas D; Fleming PR; Brown DG; Zhang M; Ferguson D; Wu D; Yu Q
    Bioorg Med Chem Lett; 2013 Dec; 23(24):6789-93. PubMed ID: 24211022
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of novel benzothienoazepine derivatives as potent inhibitors of respiratory syncytial virus.
    Fordyce EAF; Brookes DW; Lise-Ciana C; Coates MS; Hunt SF; Ito K; King-Underwood J; Onions ST; Parra GF; Rapeport G; Sherbukhin V; Stockwell JA; Strong P; Thomas JC; Murray J
    Bioorg Med Chem Lett; 2017 May; 27(10):2201-2206. PubMed ID: 28372911
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery of β-D-2'-deoxy-2'-α-fluoro-4'-α-cyano-5-aza-7,9-dideaza adenosine as a potent nucleoside inhibitor of respiratory syncytial virus with excellent selectivity over mitochondrial RNA and DNA polymerases.
    Clarke MO; Mackman R; Byun D; Hui H; Barauskas O; Birkus G; Chun BK; Doerffler E; Feng J; Karki K; Lee G; Perron M; Siegel D; Swaminathan S; Lee W
    Bioorg Med Chem Lett; 2015 Jun; 25(12):2484-7. PubMed ID: 25978965
    [TBL] [Abstract][Full Text] [Related]  

  • 7. New antiviral approaches for respiratory syncytial virus and other mononegaviruses: Inhibiting the RNA polymerase.
    Fearns R; Deval J
    Antiviral Res; 2016 Oct; 134():63-76. PubMed ID: 27575793
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Inhibitors of respiratory syncytial virus replication target cotranscriptional mRNA guanylylation by viral RNA-dependent RNA polymerase.
    Liuzzi M; Mason SW; Cartier M; Lawetz C; McCollum RS; Dansereau N; Bolger G; Lapeyre N; Gaudette Y; Lagacé L; Massariol MJ; Dô F; Whitehead P; Lamarre L; Scouten E; Bordeleau J; Landry S; Rancourt J; Fazal G; Simoneau B
    J Virol; 2005 Oct; 79(20):13105-15. PubMed ID: 16189012
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Respiratory Syncytial Virus Inhibitor AZ-27 Differentially Inhibits Different Polymerase Activities at the Promoter.
    Noton SL; Nagendra K; Dunn EF; Mawhorter ME; Yu Q; Fearns R
    J Virol; 2015 Aug; 89(15):7786-98. PubMed ID: 25995255
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Identification of Non-Nucleoside Inhibitors of the Respiratory Syncytial Virus Polymerase Complex.
    Jiménez-Somarribas A; Mao S; Yoon JJ; Weisshaar M; Cox RM; Marengo JR; Mitchell DG; Morehouse ZP; Yan D; Solis I; Liotta DC; Natchus MG; Plemper RK
    J Med Chem; 2017 Mar; 60(6):2305-2325. PubMed ID: 28245119
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Late therapeutic intervention with a respiratory syncytial virus L-protein polymerase inhibitor, PC786, on respiratory syncytial virus infection in human airway epithelium.
    Brookes DW; Coates M; Allen H; Daly L; Constant S; Huang S; Hows M; Davis A; Cass L; Ayrton J; Knowles I; Strong P; Rapeport G; Ito K
    Br J Pharmacol; 2018 Jun; 175(12):2520-2534. PubMed ID: 29579332
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Direct Inhibition of Cellular Fatty Acid Synthase Impairs Replication of Respiratory Syncytial Virus and Other Respiratory Viruses.
    Ohol YM; Wang Z; Kemble G; Duke G
    PLoS One; 2015; 10(12):e0144648. PubMed ID: 26659560
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine
    Mackman RL; Hui HC; Perron M; Murakami E; Palmiotti C; Lee G; Stray K; Zhang L; Goyal B; Chun K; Byun D; Siegel D; Simonovich S; Du Pont V; Pitts J; Babusis D; Vijjapurapu A; Lu X; Kim C; Zhao X; Chan J; Ma B; Lye D; Vandersteen A; Wortman S; Barrett KT; Toteva M; Jordan R; Subramanian R; Bilello JP; Cihlar T
    J Med Chem; 2021 Apr; 64(8):5001-5017. PubMed ID: 33835812
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Activity of Oral ALS-008176 in a Respiratory Syncytial Virus Challenge Study.
    DeVincenzo JP; McClure MW; Symons JA; Fathi H; Westland C; Chanda S; Lambkin-Williams R; Smith P; Zhang Q; Beigelman L; Blatt LM; Fry J
    N Engl J Med; 2015 Nov; 373(21):2048-58. PubMed ID: 26580997
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Respiratory syncytial virus-A dynamics and the effects of lumicitabine, a nucleoside viral replication inhibitor, in experimentally infected humans.
    Patel K; Kirkpatrick CM; Nieforth KA; Chanda S; Zhang Q; McClure M; Fry J; Symons JA; Blatt LM; Beigelman L; DeVincenzo JP; Huntjens DR; Smith PF
    J Antimicrob Chemother; 2019 Feb; 74(2):442-452. PubMed ID: 30376079
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Novel anti-RSV dianionic dendrimer-like compounds: design, synthesis and biological evaluation.
    Gazumyan A; Mitsner B; Ellestad GA
    Curr Pharm Des; 2000 Mar; 6(5):525-46. PubMed ID: 10788595
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Preclinical Characterization of PC786, an Inhaled Small-Molecule Respiratory Syncytial Virus L Protein Polymerase Inhibitor.
    Coates M; Brookes D; Kim YI; Allen H; Fordyce EAF; Meals EA; Colley T; Ciana CL; Parra GF; Sherbukhin V; Stockwell JA; Thomas JC; Hunt SF; Anderson-Dring L; Onions ST; Cass L; Murray PJ; Ito K; Strong P; DeVincenzo JP; Rapeport G
    Antimicrob Agents Chemother; 2017 Sep; 61(9):. PubMed ID: 28652242
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The antiviral effects of RSV fusion inhibitor, MDT-637, on clinical isolates, vs its achievable concentrations in the human respiratory tract and comparison to ribavirin.
    Kim YI; Pareek R; Murphy R; Harrison L; Farrell E; Cook R; DeVincenzo J
    Influenza Other Respir Viruses; 2017 Nov; 11(6):525-530. PubMed ID: 28990339
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Development of an allosteric inhibitor class blocking RNA elongation by the respiratory syncytial virus polymerase complex.
    Cox RM; Toots M; Yoon JJ; Sourimant J; Ludeke B; Fearns R; Bourque E; Patti J; Lee E; Vernachio J; Plemper RK
    J Biol Chem; 2018 Oct; 293(43):16761-16777. PubMed ID: 30206124
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Drug candidates and model systems in respiratory syncytial virus antiviral drug discovery.
    Heylen E; Neyts J; Jochmans D
    Biochem Pharmacol; 2017 Mar; 127():1-12. PubMed ID: 27659812
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.