447 related articles for article (PubMed ID: 25668494)
1. Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidines as potential nonclassical antifolates targeting both thymidylate and purine nucleotide biosynthesis.
Liu Y; Zhang C; Zhang H; Li M; Yuan J; Zhang Y; Zhou J; Guo H; Zhao L; Du Y; Wang L; Ren L
Eur J Med Chem; 2015 Mar; 93():142-55. PubMed ID: 25668494
[TBL] [Abstract][Full Text] [Related]
2. Novel 6-substituted benzoyl and non-benzoyl straight chain pyrrolo[2,3-d]pyrimidines as potential antitumor agents with multitargeted inhibition of TS, GARFTase and AICARFTase.
Xing R; Zhang H; Yuan J; Zhang K; Li L; Guo H; Zhao L; Zhang C; Li S; Gao T; Liu Y; Wang L
Eur J Med Chem; 2017 Oct; 139():531-541. PubMed ID: 28830032
[TBL] [Abstract][Full Text] [Related]
3. Discovery of 5-substituted pyrrolo[2,3-d]pyrimidine antifolates as dual-acting inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis: implications of inhibiting 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase to ampk activation and antitumor activity.
Mitchell-Ryan S; Wang Y; Raghavan S; Ravindra MP; Hales E; Orr S; Cherian C; Hou Z; Matherly LH; Gangjee A
J Med Chem; 2013 Dec; 56(24):10016-10032. PubMed ID: 24256410
[TBL] [Abstract][Full Text] [Related]
4. Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of TS and AICARFTase and as potential antitumor agents.
Liu Y; Li M; Zhang H; Yuan J; Zhang C; Zhang K; Guo H; Zhao L; Du Y; Wang L; Ren L
Eur J Med Chem; 2016 Jun; 115():245-56. PubMed ID: 27017552
[TBL] [Abstract][Full Text] [Related]
5. Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.
Golani LK; Wallace-Povirk A; Deis SM; Wong J; Ke J; Gu X; Raghavan S; Wilson MR; Li X; Polin L; de Waal PW; White K; Kushner J; O'Connor C; Hou Z; Xu HE; Melcher K; Dann CE; Matherly LH; Gangjee A
J Med Chem; 2016 Sep; 59(17):7856-76. PubMed ID: 27458733
[TBL] [Abstract][Full Text] [Related]
6. Tumor-targeting with novel non-benzoyl 6-substituted straight chain pyrrolo[2,3-d]pyrimidine antifolates via cellular uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis.
Wang Y; Cherian C; Orr S; Mitchell-Ryan S; Hou Z; Raghavan S; Matherly LH; Gangjee A
J Med Chem; 2013 Nov; 56(21):8684-95. PubMed ID: 24111942
[TBL] [Abstract][Full Text] [Related]
7. Discovery of amide-bridged pyrrolo[2,3-d]pyrimidines as tumor targeted classical antifolates with selective uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis.
Xiang W; Dekhne A; Doshi A; O'Connor C; Hou Z; Matherly LH; Gangjee A
Bioorg Med Chem; 2019 Dec; 27(23):115125. PubMed ID: 31679978
[TBL] [Abstract][Full Text] [Related]
8. Novel 5-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase and as potential antitumor agents.
Wang Y; Mitchell-Ryan S; Raghavan S; George C; Orr S; Hou Z; Matherly LH; Gangjee A
J Med Chem; 2015 Feb; 58(3):1479-93. PubMed ID: 25602637
[TBL] [Abstract][Full Text] [Related]
9. Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as dual inhibitors of dihydrofolate reductase and thymidylate synthase and as potential antitumor agents.
Gangjee A; Lin X; Kisliuk RL; McGuire JJ
J Med Chem; 2005 Nov; 48(23):7215-22. PubMed ID: 16279780
[TBL] [Abstract][Full Text] [Related]
10. Targeting dihydrofolate reductase: Design, synthesis and biological evaluation of novel 6-substituted pyrrolo[2,3-d]pyrimidines as nonclassical antifolates and as potential antitumor agents.
Gao T; Zhang C; Shi X; Guo R; Zhang K; Gu J; Li L; Li S; Zheng Q; Cui M; Cui M; Gao X; Liu Y; Wang L
Eur J Med Chem; 2019 Sep; 178():329-340. PubMed ID: 31200235
[TBL] [Abstract][Full Text] [Related]
11. Dual inhibitors of thymidylate synthase and dihydrofolate reductase as antitumor agents: design, synthesis, and biological evaluation of classical and nonclassical pyrrolo[2,3-d]pyrimidine antifolates(1).
Gangjee A; Jain HD; Phan J; Lin X; Song X; McGuire JJ; Kisliuk RL
J Med Chem; 2006 Feb; 49(3):1055-65. PubMed ID: 16451071
[TBL] [Abstract][Full Text] [Related]
12. Design, synthesis and biological evaluation of novel 6-substituted pyrrolo [3,2-d] pyrimidine analogues as antifolate antitumor agents.
Tian C; Wang M; Han Z; Fang F; Zhang Z; Wang X; Liu J
Eur J Med Chem; 2017 Sep; 138():630-643. PubMed ID: 28711701
[TBL] [Abstract][Full Text] [Related]
13. Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines.
Gangjee A; Vidwans A; Elzein E; McGuire JJ; Queener SF; Kisliuk RL
J Med Chem; 2001 Jun; 44(12):1993-2003. PubMed ID: 11384244
[TBL] [Abstract][Full Text] [Related]
14. Novel 2-amino-4-oxo-5-arylthio-substituted-pyrrolo[2,3-d]pyrimidines as nonclassical antifolate inhibitors of thymidylate synthase.
Gangjee A; Jain HD; Kisliuk RL
Bioorg Med Chem Lett; 2005 May; 15(9):2225-30. PubMed ID: 15837298
[TBL] [Abstract][Full Text] [Related]
15. Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits β-glycinamide ribonucleotide formyltransferase.
Wang L; Desmoulin SK; Cherian C; Polin L; White K; Kushner J; Fulterer A; Chang MH; Mitchell-Ryan S; Stout M; Romero MF; Hou Z; Matherly LH; Gangjee A
J Med Chem; 2011 Oct; 54(20):7150-64. PubMed ID: 21879757
[TBL] [Abstract][Full Text] [Related]
16. Classical and nonclassical furo[2,3-d]pyrimidines as novel antifolates: synthesis and biological activities.
Gangjee A; Devraj R; McGuire JJ; Kisliuk RL; Queener SF; Barrows LR
J Med Chem; 1994 Apr; 37(8):1169-76. PubMed ID: 8164259
[TBL] [Abstract][Full Text] [Related]
17. 5-Arylthio-substituted 2-amino-4-oxo-6-methylpyrrolo[2,3-d]pyrimidine antifolates as thymidylate synthase inhibitors and antitumor agents.
Gangjee A; Devraj R; McGuire JJ; Kisliuk RL
J Med Chem; 1995 Oct; 38(22):4495-502. PubMed ID: 7473577
[TBL] [Abstract][Full Text] [Related]
18. 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors.
Wang L; Wallace A; Raghavan S; Deis SM; Wilson MR; Yang S; Polin L; White K; Kushner J; Orr S; George C; O'Connor C; Hou Z; Mitchell-Ryan S; Dann CE; Matherly LH; Gangjee A
J Med Chem; 2015 Sep; 58(17):6938-59. PubMed ID: 26317331
[TBL] [Abstract][Full Text] [Related]
19. Design and synthesis of classical and nonclassical 6-arylthio-2,4-diamino-5-ethylpyrrolo[2,3-d]pyrimidines as antifolates.
Gangjee A; Zeng Y; Talreja T; McGuire JJ; Kisliuk RL; Queener SF
J Med Chem; 2007 Jun; 50(13):3046-53. PubMed ID: 17552508
[TBL] [Abstract][Full Text] [Related]
20. Synthesis and discovery of high affinity folate receptor-specific glycinamide ribonucleotide formyltransferase inhibitors with antitumor activity.
Deng Y; Wang Y; Cherian C; Hou Z; Buck SA; Matherly LH; Gangjee A
J Med Chem; 2008 Aug; 51(16):5052-63. PubMed ID: 18680275
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]