BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

195 related articles for article (PubMed ID: 25670876)

  • 1. Molecular docking approaches in identification of High affinity inhibitors of Human SMO receptor.
    Akare UR; Bandaru S; Shaheen U; Singh PK; Tiwari G; Singare P; Nayarisseri A; Banerjee T
    Bioinformation; 2014; 10(12):737-42. PubMed ID: 25670876
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The dawn of hedgehog inhibitors: Vismodegib.
    Sandhiya S; Melvin G; Kumar SS; Dkhar SA
    J Pharmacol Pharmacother; 2013 Jan; 4(1):4-7. PubMed ID: 23662017
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Pharmacological evaluation of a series of smoothened antagonists in signaling pathways and after topical application in a depilated mouse model.
    Lauressergues E; Heusler P; Lestienne F; Troulier D; Rauly-Lestienne I; Tourette A; Ailhaud MC; Cathala C; Tardif S; Denais-Laliève D; Calmettes MT; Degryse AD; Dumoulin A; De Vries L; Cussac D
    Pharmacol Res Perspect; 2016 Apr; 4(2):e00214. PubMed ID: 27069629
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Biochemical characterization of smoothened receptor antagonists by binding kinetics against drug-resistant mutant.
    Shimizu Y; Ishii T; Ogawa K; Sasaki S; Matsui H; Nakayama M
    Eur J Pharmacol; 2015 Oct; 764():220-227. PubMed ID: 26048307
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Inhibition mechanism exploration of investigational drug TAK-441 as inhibitor against Vismodegib-resistant Smoothened mutant.
    Ishii T; Shimizu Y; Nakashima K; Kondo S; Ogawa K; Sasaki S; Matsui H
    Eur J Pharmacol; 2014 Jan; 723():305-13. PubMed ID: 24291104
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Ligand-based 3D pharmacophore modeling, virtual screening, and molecular dynamic simulation of potential smoothened inhibitors.
    Mohebbi A
    J Mol Model; 2023 Apr; 29(5):143. PubMed ID: 37062794
    [TBL] [Abstract][Full Text] [Related]  

  • 7. B13, a well-tolerated inhibitor of hedgehog pathway, exhibited potent anti-tumor effects against colorectal carcinoma in vitro and in vivo.
    Wu H; Zhang L; Chen B; Ou B; Xu J; Tian N; Yang D; Ai Y; Chen Q; Quan D; Zhang T; Lv L; Tian Y; Zhang J; Wu S
    Bioorg Chem; 2023 Jun; 135():106488. PubMed ID: 36989734
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Impact of the Smoothened inhibitor, IPI-926, on smoothened ciliary localization and Hedgehog pathway activity.
    Peluso MO; Campbell VT; Harari JA; Tibbitts TT; Proctor JL; Whitebread N; Conley JM; White KF; Kutok JL; Read MA; McGovern K; Faia KL
    PLoS One; 2014; 9(3):e90534. PubMed ID: 24608250
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Response to inhibition of smoothened in diverse epithelial cancer cells that lack smoothened or patched 1 mutations.
    Galimberti F; Busch AM; Chinyengetere F; Ma T; Sekula D; Memoli VA; Dragnev KH; Liu F; Johnson KC; Guo Y; Freemantle SJ; Andrew AS; Greninger P; Robbins DJ; Settleman J; Benes C; Dmitrovsky E
    Int J Oncol; 2012 Nov; 41(5):1751-61. PubMed ID: 22923130
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Molecular Modelling of Berberine Derivatives as Inhibitors of Human Smoothened Receptor and Hedgehog Signalling Pathway Using a Newly Developed Algorithm on Anti-Cancer Drugs.
    Kaboli PJ; Bazrafkan M; Ismail P; Ling KH
    Recent Pat Anticancer Drug Discov; 2017 Nov; 12(4):384-400. PubMed ID: 28969581
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Targeting of the Hedgehog signal transduction pathway suppresses survival of malignant pleural mesothelioma cells in vitro.
    You M; Varona-Santos J; Singh S; Robbins DJ; Savaraj N; Nguyen DM
    J Thorac Cardiovasc Surg; 2014 Jan; 147(1):508-16. PubMed ID: 24094913
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Inhibition of CAL27 Oral Squamous Carcinoma Cell by Targeting Hedgehog Pathway With Vismodegib or Itraconazole.
    Freitas RD; Dias RB; Vidal MTA; Valverde LF; Gomes Alves Costa R; Damasceno AKA; Sales CBS; Siquara da Rocha LO; Dos Reis MG; Soares MBP; Coletta RD; Pereira TA; Bezerra DP; Gurgel Rocha CA
    Front Oncol; 2020; 10():563838. PubMed ID: 33312948
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The PROTAC selectively degrading Bcl-x
    Zhang S; Chen Y; Xu Z; Yang J; Sun R; Wang J; Sun Y; Jiang B; Yang X; Tan W
    Theranostics; 2022; 12(17):7476-7490. PubMed ID: 36438482
    [No Abstract]   [Full Text] [Related]  

  • 14. Non-canonical Hedgehog Signaling Pathway in Cancer: Activation of GLI Transcription Factors Beyond Smoothened.
    Pietrobono S; Gagliardi S; Stecca B
    Front Genet; 2019; 10():556. PubMed ID: 31244888
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Novel-smoothened inhibitors for therapeutic targeting of naïve and drug-resistant hedgehog pathway-driven cancers.
    Li QR; Zhao H; Zhang XS; Lang H; Yu K
    Acta Pharmacol Sin; 2019 Feb; 40(2):257-267. PubMed ID: 29777201
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Posaconazole, a Second-Generation Triazole Antifungal Drug, Inhibits the Hedgehog Signaling Pathway and Progression of Basal Cell Carcinoma.
    Chen B; Trang V; Lee A; Williams NS; Wilson AN; Epstein EH; Tang JY; Kim J
    Mol Cancer Ther; 2016 May; 15(5):866-76. PubMed ID: 26823493
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Discovery of [1,2,4]triazolo[4,3-a]pyridines as potent Smoothened inhibitors targeting the Hedgehog pathway with improved antitumor activity in vivo.
    Tian N; Wu H; Zhang H; Yang D; Lv L; Yang Z; Zhang T; Quan D; Zhou L; Xie Y; Xu Y; Wei N; Zhang J; Chen M; Schmitz JC; Tian Y; Wu S
    Bioorg Med Chem; 2020 Aug; 28(16):115584. PubMed ID: 32690258
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Molecular pathways: novel approaches for improved therapeutic targeting of Hedgehog signaling in cancer stem cells.
    Justilien V; Fields AP
    Clin Cancer Res; 2015 Feb; 21(3):505-13. PubMed ID: 25646180
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype.
    Infante P; Alfonsi R; Ingallina C; Quaglio D; Ghirga F; D'Acquarica I; Bernardi F; Di Magno L; Canettieri G; Screpanti I; Gulino A; Botta B; Mori M; Di Marcotullio L
    Cell Death Dis; 2016 Sep; 7(9):e2376. PubMed ID: 27899820
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Phosphoproteomics of short-term hedgehog signaling in human medulloblastoma cells.
    Scheidt T; Alka O; Gonczarowska-Jorge H; Gruber W; Rathje F; Dell'Aica M; Rurik M; Kohlbacher O; Zahedi RP; Aberger F; Huber CG
    Cell Commun Signal; 2020 Jun; 18(1):99. PubMed ID: 32576205
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.