BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

162 related articles for article (PubMed ID: 25680530)

  • 1. The activity of cAMP-phosphodiesterase 4D7 (PDE4D7) is regulated by protein kinase A-dependent phosphorylation within its unique N-terminus.
    Byrne AM; Elliott C; Hoffmann R; Baillie GS
    FEBS Lett; 2015 Mar; 589(6):750-5. PubMed ID: 25680530
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Cloning and characterization of novel PDE4D isoforms PDE4D6 and PDE4D7.
    Wang D; Deng C; Bugaj-Gaweda B; Kwan M; Gunwaldsen C; Leonard C; Xin X; Hu Y; Unterbeck A; De Vivo M
    Cell Signal; 2003 Sep; 15(9):883-91. PubMed ID: 12834813
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1).
    MacKenzie SJ; Baillie GS; McPhee I; MacKenzie C; Seamons R; McSorley T; Millen J; Beard MB; van Heeke G; Houslay MD
    Br J Pharmacol; 2002 Jun; 136(3):421-33. PubMed ID: 12023945
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Ndel1 alters its conformation by sequestering cAMP-specific phosphodiesterase-4D3 (PDE4D3) in a manner that is dynamically regulated through Protein Kinase A (PKA).
    Collins DM; Murdoch H; Dunlop AJ; Charych E; Baillie GS; Wang Q; Herberg FW; Brandon N; Prinz A; Houslay MD
    Cell Signal; 2008 Dec; 20(12):2356-69. PubMed ID: 18845247
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The upstream conserved regions (UCRs) mediate homo- and hetero-oligomerization of type 4 cyclic nucleotide phosphodiesterases (PDE4s).
    Xie M; Blackman B; Scheitrum C; Mika D; Blanchard E; Lei T; Conti M; Richter W
    Biochem J; 2014 May; 459(3):539-50. PubMed ID: 24555506
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The cAMP phosphodiesterase-4D7 (PDE4D7) is downregulated in androgen-independent prostate cancer cells and mediates proliferation by compartmentalising cAMP at the plasma membrane of VCaP prostate cancer cells.
    Henderson DJ; Byrne A; Dulla K; Jenster G; Hoffmann R; Baillie GS; Houslay MD
    Br J Cancer; 2014 Mar; 110(5):1278-87. PubMed ID: 24518597
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners.
    Houslay KF; Christian F; MacLeod R; Adams DR; Houslay MD; Baillie GS
    Biochem J; 2017 Feb; 474(4):597-609. PubMed ID: 27993970
    [TBL] [Abstract][Full Text] [Related]  

  • 8. cAMP-phosphodiesterase 4D7 (PDE4D7) forms a cAMP signalosome complex with DHX9 and is implicated in prostate cancer progression.
    Gulliver C; Busiau T; Byrne A; Findlay JE; Hoffmann R; Baillie GS
    Mol Oncol; 2024 Mar; 18(3):707-725. PubMed ID: 38126155
    [TBL] [Abstract][Full Text] [Related]  

  • 9. UCR1 and UCR2 domains unique to the cAMP-specific phosphodiesterase family form a discrete module via electrostatic interactions.
    Beard MB; Olsen AE; Jones RE; Erdogan S; Houslay MD; Bolger GB
    J Biol Chem; 2000 Apr; 275(14):10349-58. PubMed ID: 10744723
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains.
    Bolger GB; Dunlop AJ; Meng D; Day JP; Klussmann E; Baillie GS; Adams DR; Houslay MD
    Cell Signal; 2015 Apr; 27(4):756-69. PubMed ID: 25546709
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Mitotic activation of the DISC1-inducible cyclic AMP phosphodiesterase-4D9 (PDE4D9), through multi-site phosphorylation, influences cell cycle progression.
    Sheppard CL; Lee LC; Hill EV; Henderson DJ; Anthony DF; Houslay DM; Yalla KC; Cairns LS; Dunlop AJ; Baillie GS; Huston E; Houslay MD
    Cell Signal; 2014 Sep; 26(9):1958-74. PubMed ID: 24815749
    [TBL] [Abstract][Full Text] [Related]  

  • 12. In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region.
    McCahill A; McSorley T; Huston E; Hill EV; Lynch MJ; Gall I; Keryer G; Lygren B; Tasken K; van Heeke G; Houslay MD
    Cell Signal; 2005 Sep; 17(9):1158-73. PubMed ID: 15905070
    [TBL] [Abstract][Full Text] [Related]  

  • 13. UCR1C is a novel activator of phosphodiesterase 4 (PDE4) long isoforms and attenuates cardiomyocyte hypertrophy.
    Wang L; Burmeister BT; Johnson KR; Baillie GS; Karginov AV; Skidgel RA; O'Bryan JP; Carnegie GK
    Cell Signal; 2015 May; 27(5):908-22. PubMed ID: 25683917
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK.
    Li X; Vadrevu S; Dunlop A; Day J; Advant N; Troeger J; Klussmann E; Jaffrey E; Hay RT; Adams DR; Houslay MD; Baillie GS
    Biochem J; 2010 Apr; 428(1):55-65. PubMed ID: 20196770
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The role of ERK2 docking and phosphorylation of PDE4 cAMP phosphodiesterase isoforms in mediating cross-talk between the cAMP and ERK signalling pathways.
    Houslay MD; Baillie GS
    Biochem Soc Trans; 2003 Dec; 31(Pt 6):1186-90. PubMed ID: 14641023
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Validation of Cyclic Adenosine Monophosphate Phosphodiesterase-4D7 for its Independent Contribution to Risk Stratification in a Prostate Cancer Patient Cohort with Longitudinal Biological Outcomes.
    Alves de Inda M; van Strijp D; den Biezen-Timmermans E; van Brussel A; Wrobel J; van Zon H; Vos P; Baillie GS; Tennstedt P; Schlomm T; Houslay MD; Bangma C; Hoffmann R
    Eur Urol Focus; 2018 Apr; 4(3):376-384. PubMed ID: 28753810
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Identification and characterization of PDE4A11, a novel, widely expressed long isoform encoded by the human PDE4A cAMP phosphodiesterase gene.
    Wallace DA; Johnston LA; Huston E; MacMaster D; Houslay TM; Cheung YF; Campbell L; Millen JE; Smith RA; Gall I; Knowles RG; Sullivan M; Houslay MD
    Mol Pharmacol; 2005 Jun; 67(6):1920-34. PubMed ID: 15738310
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activation.
    Sette C; Conti M
    J Biol Chem; 1996 Jul; 271(28):16526-34. PubMed ID: 8663227
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Investigation of extracellular signal-regulated kinase 2 mitogen-activated protein kinase phosphorylation and regulation of activity of PDE4 cyclic adenosine monophosphate-specific phosphodiesterases.
    Hill EV; Houslay MD; Baillie GS
    Methods Mol Biol; 2005; 307():225-37. PubMed ID: 15988067
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Creating a potential diagnostic for prostate cancer risk stratification (InformMDx™) by translating novel scientific discoveries concerning cAMP degrading phosphodiesterase-4D7 (PDE4D7).
    Henderson DJP; Houslay MD; Bangma CH; Hoffmann R
    Clin Sci (Lond); 2019 Jan; 133(2):269-286. PubMed ID: 30683712
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.