384 related articles for article (PubMed ID: 25691154)
1. Targeted inhibition of the deubiquitinating enzymes, USP14 and UCHL5, induces proteotoxic stress and apoptosis in Waldenström macroglobulinaemia tumour cells.
Chitta K; Paulus A; Akhtar S; Blake MK; Caulfield TR; Novak AJ; Ansell SM; Advani P; Ailawadhi S; Sher T; Linder S; Chanan-Khan A
Br J Haematol; 2015 May; 169(3):377-90. PubMed ID: 25691154
[TBL] [Abstract][Full Text] [Related]
2. A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance.
Tian Z; D'Arcy P; Wang X; Ray A; Tai YT; Hu Y; Carrasco RD; Richardson P; Linder S; Chauhan D; Anderson KC
Blood; 2014 Jan; 123(5):706-16. PubMed ID: 24319254
[TBL] [Abstract][Full Text] [Related]
3. Coinhibition of the deubiquitinating enzymes, USP14 and UCHL5, with VLX1570 is lethal to ibrutinib- or bortezomib-resistant Waldenstrom macroglobulinemia tumor cells.
Paulus A; Akhtar S; Caulfield TR; Samuel K; Yousaf H; Bashir Y; Paulus SM; Tran D; Hudec R; Cogen D; Jiang J; Edenfield B; Novak A; Ansell SM; Witzig T; Martin P; Coleman M; Roy V; Ailawadhi S; Chitta K; Linder S; Chanan-Khan A
Blood Cancer J; 2016 Nov; 6(11):e492. PubMed ID: 27813535
[TBL] [Abstract][Full Text] [Related]
4. Inhibition of proteasomal deubiquitinases USP14 and UCHL5 overcomes tyrosine kinase inhibitor resistance in chronic myeloid leukaemia.
Jiang L; He Q; Chen X; Liu A; Ding W; Zhang H; Chen X; Zhou H; Meng Y; Liu B; Peng G; Wang C; Liu J; Shi X
Clin Transl Med; 2022 Sep; 12(9):e1038. PubMed ID: 36082692
[TBL] [Abstract][Full Text] [Related]
5. Induction of tumor cell apoptosis by a proteasome deubiquitinase inhibitor is associated with oxidative stress.
Brnjic S; Mazurkiewicz M; Fryknäs M; Sun C; Zhang X; Larsson R; D'Arcy P; Linder S
Antioxid Redox Signal; 2014 Dec; 21(17):2271-85. PubMed ID: 24011031
[TBL] [Abstract][Full Text] [Related]
6. The deubiquitinase inhibitor b-AP15 induces strong proteotoxic stress and mitochondrial damage.
Zhang X; Pellegrini P; Saei AA; Hillert EK; Mazurkiewicz M; Olofsson MH; Zubarev RA; D'Arcy P; Linder S
Biochem Pharmacol; 2018 Oct; 156():291-301. PubMed ID: 30149015
[TBL] [Abstract][Full Text] [Related]
7. Inhibition of proteasome deubiquitinating activity as a new cancer therapy.
D'Arcy P; Brnjic S; Olofsson MH; Fryknäs M; Lindsten K; De Cesare M; Perego P; Sadeghi B; Hassan M; Larsson R; Linder S
Nat Med; 2011 Nov; 17(12):1636-40. PubMed ID: 22057347
[TBL] [Abstract][Full Text] [Related]
8. Proteasomal cysteine deubiquitinase inhibitor b-AP15 suppresses migration and induces apoptosis in diffuse large B cell lymphoma.
Jiang L; Sun Y; Wang J; He Q; Chen X; Lan X; Chen J; Dou QP; Shi X; Liu J
J Exp Clin Cancer Res; 2019 Nov; 38(1):453. PubMed ID: 31694672
[TBL] [Abstract][Full Text] [Related]
9. Targeting proteasomal deubiquitinases USP14 and UCHL5 with b-AP15 reduces 5-fluorouracil resistance in colorectal cancer cells.
Ding W; Wang JX; Wu JZ; Liu AC; Jiang LL; Zhang HC; Meng Y; Liu BY; Peng GJ; Lou EZ; Mao Q; Zhou H; Tang DL; Chen X; Liu JB; Shi XP
Acta Pharmacol Sin; 2023 Dec; 44(12):2537-2548. PubMed ID: 37528233
[TBL] [Abstract][Full Text] [Related]
10. A ubiquitinome analysis to study the functional roles of the proteasome associated deubiquitinating enzymes USP14 and UCH37.
van der Wal L; Bezstarosti K; Demmers JAA
J Proteomics; 2022 Jun; 262():104592. PubMed ID: 35489684
[TBL] [Abstract][Full Text] [Related]
11. Treatment with b-AP15 to Inhibit UCHL5 and USP14 Deubiquitinating Activity and Enhance p27 and Cyclin E1 for Tumors with
Jiang ZY; Hong J; Zhang JH; Wang XF; Ma YS; Xiong ZX; Sun HR; Cheng C; Xie BZ; Liu JB; Ouyang YG; Fu D
Technol Cancer Res Treat; 2022; 21():15330338221119745. PubMed ID: 35971329
[No Abstract] [Full Text] [Related]
12. Proteasome inhibitor b-AP15 induces enhanced proteotoxicity by inhibiting cytoprotective aggresome formation.
Hillert EK; Brnjic S; Zhang X; Mazurkiewicz M; Saei AA; Mofers A; Selvaraju K; Zubarev R; Linder S; D'Arcy P
Cancer Lett; 2019 Apr; 448():70-83. PubMed ID: 30768956
[TBL] [Abstract][Full Text] [Related]
13. Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells.
Chadchankar J; Korboukh V; Conway LC; Wobst HJ; Walker CA; Doig P; Jacobsen SJ; Brandon NJ; Moss SJ; Wang Q
PLoS One; 2019; 14(11):e0225145. PubMed ID: 31703099
[TBL] [Abstract][Full Text] [Related]
14. The role of 19S proteasome associated deubiquitinases in activity-dependent hippocampal synaptic plasticity.
Yun D; Zhuang Y; Kreutz MR; Behnisch T
Neuropharmacology; 2018 May; 133():354-365. PubMed ID: 29407217
[TBL] [Abstract][Full Text] [Related]
15. Computational and biochemical studies of isothiocyanates as inhibitors of proteasomal cysteine deubiquitinases in human cancer cells.
Ahmed ZSO; Li X; Li F; Cheaito HA; Patel K; Mosallam EM; Elbargeesy GAEH; Dou QP
J Cell Biochem; 2018 Nov; 119(11):9006-9016. PubMed ID: 30015387
[TBL] [Abstract][Full Text] [Related]
16. Repurposing of auranofin: Thioredoxin reductase remains a primary target of the drug.
Zhang X; Selvaraju K; Saei AA; D'Arcy P; Zubarev RA; Arnér ES; Linder S
Biochimie; 2019 Jul; 162():46-54. PubMed ID: 30946948
[TBL] [Abstract][Full Text] [Related]
17. Inhibition of 19S proteasome deubiquitinating activity in Schistosoma mansoni affects viability, oviposition, and structural changes.
do Patrocinio AB; Cabral FJ; Bitencourt ALB; Brigato OM; Magalhães LG; de Lima Paula LA; Franco L; Guerra-Sá And R; Rodrigues V
Parasitol Res; 2020 Jul; 119(7):2159-2176. PubMed ID: 32424554
[TBL] [Abstract][Full Text] [Related]
18. Cadmium pyrithione suppresses tumor growth in vitro and in vivo through inhibition of proteasomal deubiquitinase.
Chen X; Wu J; Yang Q; Zhang X; Zhang P; Liao S; He Z; Wang X; Zhao C; Liu J
Biometals; 2018 Feb; 31(1):29-43. PubMed ID: 29098502
[TBL] [Abstract][Full Text] [Related]
19. Ubiquitinated proteins promote the association of proteasomes with the deubiquitinating enzyme Usp14 and the ubiquitin ligase Ube3c.
Kuo CL; Goldberg AL
Proc Natl Acad Sci U S A; 2017 Apr; 114(17):E3404-E3413. PubMed ID: 28396413
[TBL] [Abstract][Full Text] [Related]
20. Oxidative Stress Induced by the Deubiquitinase Inhibitor b-AP15 Is Associated with Mitochondrial Impairment.
Zhang X; Espinosa B; Saei AA; D'Arcy P; Zubarev RA; Linder S
Oxid Med Cell Longev; 2019; 2019():1659468. PubMed ID: 31281566
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]