BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

329 related articles for article (PubMed ID: 25694214)

  • 1. Platelet adhesion to podoplanin under flow is mediated by the receptor CLEC-2 and stabilised by Src/Syk-dependent platelet signalling.
    Navarro-Núñez L; Pollitt AY; Lowe K; Latif A; Nash GB; Watson SP
    Thromb Haemost; 2015 May; 113(5):1109-20. PubMed ID: 25694214
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Syk and Src family kinases regulate C-type lectin receptor 2 (CLEC-2)-mediated clustering of podoplanin and platelet adhesion to lymphatic endothelial cells.
    Pollitt AY; Poulter NS; Gitz E; Navarro-Nuñez L; Wang YJ; Hughes CE; Thomas SG; Nieswandt B; Douglas MR; Owen DM; Jackson DG; Dustin ML; Watson SP
    J Biol Chem; 2014 Dec; 289(52):35695-710. PubMed ID: 25368330
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Inhibition of Src but not Syk causes weak reversal of GPVI-mediated platelet aggregation measured by light transmission aggregometry.
    Cheung HYF; Moran LA; Sickmann A; Heemskerk JWM; Garcia Á; Watson SP
    Platelets; 2022 Nov; 33(8):1293-1300. PubMed ID: 35535424
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The N-terminal SH2 domain of Syk is required for (hem)ITAM, but not integrin, signaling in mouse platelets.
    Hughes CE; Finney BA; Koentgen F; Lowe KL; Watson SP
    Blood; 2015 Jan; 125(1):144-54. PubMed ID: 25352128
    [TBL] [Abstract][Full Text] [Related]  

  • 5. CLEC-2-dependent activation of mouse platelets is weakly inhibited by cAMP but not by cGMP.
    Borgognone A; Navarro-Núñez L; Correia JN; Pollitt AY; Thomas SG; Eble JA; Pulcinelli FM; Madhani M; Watson SP
    J Thromb Haemost; 2014 Apr; 12(4):550-9. PubMed ID: 24460629
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Mouse podoplanin supports adhesion and aggregation of platelets under arterial shear: A novel mechanism of haemostasis.
    Lombard SE; Pollitt AY; Hughes CE; Di Y; Mckinnon T; O'callaghan CA; Watson SP
    Platelets; 2018 Nov; 29(7):716-722. PubMed ID: 29090616
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Distinct pathways regulate Syk protein activation downstream of immune tyrosine activation motif (ITAM) and hemITAM receptors in platelets.
    Manne BK; Badolia R; Dangelmaier C; Eble JA; Ellmeier W; Kahn M; Kunapuli SP
    J Biol Chem; 2015 May; 290(18):11557-68. PubMed ID: 25767114
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Platelet activation receptor CLEC-2 regulates blood/lymphatic vessel separation by inhibiting proliferation, migration, and tube formation of lymphatic endothelial cells.
    Osada M; Inoue O; Ding G; Shirai T; Ichise H; Hirayama K; Takano K; Yatomi Y; Hirashima M; Fujii H; Suzuki-Inoue K; Ozaki Y
    J Biol Chem; 2012 Jun; 287(26):22241-52. PubMed ID: 22556408
    [TBL] [Abstract][Full Text] [Related]  

  • 9. GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk.
    Hughan SC; Hughes CE; McCarty OJ; Schweighoffer E; Soultanova I; Ware J; Tybulewicz VL; Watson SP
    Arterioscler Thromb Vasc Biol; 2007 Feb; 27(2):422-9. PubMed ID: 17110603
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton.
    Obergfell A; Eto K; Mocsai A; Buensuceso C; Moores SL; Brugge JS; Lowell CA; Shattil SJ
    J Cell Biol; 2002 Apr; 157(2):265-75. PubMed ID: 11940607
    [TBL] [Abstract][Full Text] [Related]  

  • 11. G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2.
    Mori J; Pearce AC; Spalton JC; Grygielska B; Eble JA; Tomlinson MG; Senis YA; Watson SP
    J Biol Chem; 2008 Dec; 283(51):35419-27. PubMed ID: 18955485
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Targeted downregulation of platelet CLEC-2 occurs through Syk-independent internalization.
    Lorenz V; Stegner D; Stritt S; Vögtle T; Kiefer F; Witke W; Schymeinsky J; Watson SP; Walzog B; Nieswandt B
    Blood; 2015 Jun; 125(26):4069-77. PubMed ID: 25795918
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The C-type lectin receptors CLEC-2 and Dectin-1, but not DC-SIGN, signal via a novel YXXL-dependent signaling cascade.
    Fuller GL; Williams JA; Tomlinson MG; Eble JA; Hanna SL; Pöhlmann S; Suzuki-Inoue K; Ozaki Y; Watson SP; Pearce AC
    J Biol Chem; 2007 Apr; 282(17):12397-409. PubMed ID: 17339324
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Physiologic and pathophysiologic roles of interaction between C-type lectin-like receptor 2 and podoplanin: partners from in utero to adulthood.
    Suzuki-Inoue K; Osada M; Ozaki Y
    J Thromb Haemost; 2017 Feb; 15(2):219-229. PubMed ID: 27960039
    [TBL] [Abstract][Full Text] [Related]  

  • 15. CLEC-2 activates Syk through dimerization.
    Hughes CE; Pollitt AY; Mori J; Eble JA; Tomlinson MG; Hartwig JH; O'Callaghan CA; Fütterer K; Watson SP
    Blood; 2010 Apr; 115(14):2947-55. PubMed ID: 20154219
    [TBL] [Abstract][Full Text] [Related]  

  • 16. CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.
    Finney BA; Schweighoffer E; Navarro-Núñez L; Bénézech C; Barone F; Hughes CE; Langan SA; Lowe KL; Pollitt AY; Mourao-Sa D; Sheardown S; Nash GB; Smithers N; Reis e Sousa C; Tybulewicz VL; Watson SP
    Blood; 2012 Feb; 119(7):1747-56. PubMed ID: 22186994
    [TBL] [Abstract][Full Text] [Related]  

  • 17. C-type lectin-like receptor-2 (CLEC-2) is a key regulator of kappa-carrageenan-induced tail thrombosis model in mice.
    Yokomori R; Shirai T; Tsukiji N; Oishi S; Sasaki T; Takano K; Suzuki-Inoue K
    Platelets; 2023 Dec; 34(1):2281941. PubMed ID: 38010137
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells.
    Suzuki-Inoue K; Kato Y; Inoue O; Kaneko MK; Mishima K; Yatomi Y; Yamazaki Y; Narimatsu H; Ozaki Y
    J Biol Chem; 2007 Sep; 282(36):25993-6001. PubMed ID: 17616532
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Platelet Activation and Thrombus Formation over IgG Immune Complexes Requires Integrin αIIbβ3 and Lyn Kinase.
    Zhi H; Dai J; Liu J; Zhu J; Newman DK; Gao C; Newman PJ
    PLoS One; 2015; 10(8):e0135738. PubMed ID: 26291522
    [TBL] [Abstract][Full Text] [Related]  

  • 20. CEACAM2 negatively regulates hemi (ITAM-bearing) GPVI and CLEC-2 pathways and thrombus growth in vitro and in vivo.
    Alshahrani MM; Yang E; Yip J; Ghanem SS; Abdallah SL; deAngelis AM; O'Malley CJ; Moheimani F; Najjar SM; Jackson DE
    Blood; 2014 Oct; 124(15):2431-41. PubMed ID: 25085348
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 17.