232 related articles for article (PubMed ID: 25700521)
1. Kinase dynamics. Using ancient protein kinases to unravel a modern cancer drug's mechanism.
Wilson C; Agafonov RV; Hoemberger M; Kutter S; Zorba A; Halpin J; Buosi V; Otten R; Waterman D; Theobald DL; Kern D
Science; 2015 Feb; 347(6224):882-6. PubMed ID: 25700521
[TBL] [Abstract][Full Text] [Related]
2. Energetic dissection of Gleevec's selectivity toward human tyrosine kinases.
Agafonov RV; Wilson C; Otten R; Buosi V; Kern D
Nat Struct Mol Biol; 2014 Oct; 21(10):848-53. PubMed ID: 25218445
[TBL] [Abstract][Full Text] [Related]
3. Computational analysis of the binding specificity of Gleevec to Abl, c-Kit, Lck, and c-Src tyrosine kinases.
Lin YL; Roux B
J Am Chem Soc; 2013 Oct; 135(39):14741-53. PubMed ID: 24001034
[TBL] [Abstract][Full Text] [Related]
4. Conformation-selective inhibitors reveal differences in the activation and phosphate-binding loops of the tyrosine kinases Abl and Src.
Hari SB; Perera BG; Ranjitkar P; Seeliger MA; Maly DJ
ACS Chem Biol; 2013 Dec; 8(12):2734-43. PubMed ID: 24106839
[TBL] [Abstract][Full Text] [Related]
5. C6-unsubstituted pyrazolo[3,4-d]pyrimidines are dual Src/Abl inhibitors effective against imatinib mesylate resistant chronic myeloid leukemia cell lines.
Santucci MA; Corradi V; Mancini M; Manetti F; Radi M; Schenone S; Botta M
ChemMedChem; 2009 Jan; 4(1):118-26. PubMed ID: 19039816
[TBL] [Abstract][Full Text] [Related]
6. Backbone assignment of the tyrosine kinase Src catalytic domain in complex with imatinib.
Campos-Olivas R; Marenchino M; Scapozza L; Gervasio FL
Biomol NMR Assign; 2011 Oct; 5(2):221-4. PubMed ID: 21523440
[TBL] [Abstract][Full Text] [Related]
7. HS-438, a new inhibitor of imatinib-resistant BCR-ABL T315I mutation in chronic myeloid leukemia.
Yun SM; Jung KH; Kim SJ; Fang Z; Son MK; Yan HH; Lee H; Kim J; Shin S; Hong S; Hong SS
Cancer Lett; 2014 Jun; 348(1-2):50-60. PubMed ID: 24657654
[TBL] [Abstract][Full Text] [Related]
8. Combined Abl inhibitor therapy for minimizing drug resistance in chronic myeloid leukemia: Src/Abl inhibitors are compatible with imatinib.
O'Hare T; Walters DK; Stoffregen EP; Sherbenou DW; Heinrich MC; Deininger MW; Druker BJ
Clin Cancer Res; 2005 Oct; 11(19 Pt 1):6987-93. PubMed ID: 16203792
[TBL] [Abstract][Full Text] [Related]
9. Characterization of compound 584, an Abl kinase inhibitor with lasting effects.
Puttini M; Redaelli S; Moretti L; Brussolo S; Gunby RH; Mologni L; Marchesi E; Cleris L; Donella-Deana A; Drueckes P; Sala E; Lucchini V; Kubbutat M; Formelli F; Zambon A; Scapozza L; Gambacorti-Passerini C
Haematologica; 2008 May; 93(5):653-61. PubMed ID: 18367480
[TBL] [Abstract][Full Text] [Related]
10. Efficacy of dual-specific Bcr-Abl and Src-family kinase inhibitors in cells sensitive and resistant to imatinib mesylate.
Tipping AJ; Baluch S; Barnes DJ; Veach DR; Clarkson BM; Bornmann WG; Mahon FX; Goldman JM; Melo JV
Leukemia; 2004 Aug; 18(8):1352-6. PubMed ID: 15201856
[TBL] [Abstract][Full Text] [Related]
11. The design, synthesis, and evaluation of 8 hybrid DFG-out allosteric kinase inhibitors: a structural analysis of the binding interactions of Gleevec, Nexavar, and BIRB-796.
Dietrich J; Hulme C; Hurley LH
Bioorg Med Chem; 2010 Aug; 18(15):5738-48. PubMed ID: 20621496
[TBL] [Abstract][Full Text] [Related]
12. The background, discovery and clinical development of BCR-ABL inhibitors.
Lambert GK; Duhme-Klair AK; Morgan T; Ramjee MK
Drug Discov Today; 2013 Oct; 18(19-20):992-1000. PubMed ID: 23769978
[TBL] [Abstract][Full Text] [Related]
13. Molecular characterization and sensitivity of STI-571 (imatinib mesylate, Gleevec)-resistant, Bcr-Abl-positive, human acute leukemia cells to SRC kinase inhibitor PD180970 and 17-allylamino-17-demethoxygeldanamycin.
Nimmanapalli R; O'Bryan E; Huang M; Bali P; Burnette PK; Loughran T; Tepperberg J; Jove R; Bhalla K
Cancer Res; 2002 Oct; 62(20):5761-9. PubMed ID: 12384536
[TBL] [Abstract][Full Text] [Related]
14. Crystal structure of the T315I Abl mutant in complex with the aurora kinases inhibitor PHA-739358.
Modugno M; Casale E; Soncini C; Rosettani P; Colombo R; Lupi R; Rusconi L; Fancelli D; Carpinelli P; Cameron AD; Isacchi A; Moll J
Cancer Res; 2007 Sep; 67(17):7987-90. PubMed ID: 17804707
[TBL] [Abstract][Full Text] [Related]
15. Protein Flexibility and Dissociation Pathway Differentiation Can Explain Onset of Resistance Mutations in Kinases.
Shekhar M; Smith Z; Seeliger MA; Tiwary P
Angew Chem Int Ed Engl; 2022 Jul; 61(28):e202200983. PubMed ID: 35486370
[TBL] [Abstract][Full Text] [Related]
16. Synergistic interactions between DMAG and mitogen-activated protein kinase kinase 1/2 inhibitors in Bcr/abl+ leukemia cells sensitive and resistant to imatinib mesylate.
Nguyen TK; Rahmani M; Gao N; Kramer L; Corbin AS; Druker BJ; Dent P; Grant S
Clin Cancer Res; 2006 Apr; 12(7 Pt 1):2239-47. PubMed ID: 16609040
[TBL] [Abstract][Full Text] [Related]
17. Molecular dynamics simulations show that conformational selection governs the binding preferences of imatinib for several tyrosine kinases.
Aleksandrov A; Simonson T
J Biol Chem; 2010 Apr; 285(18):13807-15. PubMed ID: 20200154
[TBL] [Abstract][Full Text] [Related]
18. Targeting ABL and SRC kinases in chronic myeloid leukemia: experience with dasatinib.
Quintás-Cardama A; Kantarjian H; Cortes J
Future Oncol; 2006 Dec; 2(6):655-65. PubMed ID: 17155893
[TBL] [Abstract][Full Text] [Related]
19. ApoptomiRs expression modulated by BCR-ABL is linked to CML progression and imatinib resistance.
Ferreira AF; Moura LG; Tojal I; Ambrósio L; Pinto-Simões B; Hamerschlak N; Calin GA; Ivan C; Covas DT; Kashima S; Castro FA
Blood Cells Mol Dis; 2014; 53(1-2):47-55. PubMed ID: 24629639
[TBL] [Abstract][Full Text] [Related]
20. Evolutionary variation and adaptation in a conserved protein kinase allosteric network: implications for inhibitor design.
Oruganty K; Kannan N
Biochim Biophys Acta; 2013 Jul; 1834(7):1322-9. PubMed ID: 23499783
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
