181 related articles for article (PubMed ID: 25709040)
1. Fragment-based design of kinase inhibitors: a practical guide.
Erickson JA
Methods Mol Biol; 2015; 1289():157-83. PubMed ID: 25709040
[TBL] [Abstract][Full Text] [Related]
2. Selection of fragments for kinase inhibitor design: decoration is key.
Czodrowski P; Hölzemann G; Barnickel G; Greiner H; Musil D
J Med Chem; 2015 Jan; 58(1):457-65. PubMed ID: 25437144
[TBL] [Abstract][Full Text] [Related]
3. Fragment based lead discovery of small molecule inhibitors for the EPHA4 receptor tyrosine kinase.
van Linden OP; Farenc C; Zoutman WH; Hameetman L; Wijtmans M; Leurs R; Tensen CP; Siegal G; de Esch IJ
Eur J Med Chem; 2012 Jan; 47(1):493-500. PubMed ID: 22137457
[TBL] [Abstract][Full Text] [Related]
4. Virtual fragment preparation for computational fragment-based drug design.
Ludington JL
Methods Mol Biol; 2015; 1289():31-41. PubMed ID: 25709031
[TBL] [Abstract][Full Text] [Related]
5. Fragment-based discovery of JAK-2 inhibitors.
Antonysamy S; Hirst G; Park F; Sprengeler P; Stappenbeck F; Steensma R; Wilson M; Wong M
Bioorg Med Chem Lett; 2009 Jan; 19(1):279-82. PubMed ID: 19019674
[TBL] [Abstract][Full Text] [Related]
6. Introduction to fragment-based drug discovery.
Erlanson DA
Top Curr Chem; 2012; 317():1-32. PubMed ID: 21695633
[TBL] [Abstract][Full Text] [Related]
7. Fragment-based approaches to the discovery of kinase inhibitors.
Mortenson PN; Berdini V; O'Reilly M
Methods Enzymol; 2014; 548():69-92. PubMed ID: 25399642
[TBL] [Abstract][Full Text] [Related]
8. Fragment library design: using cheminformatics and expert chemists to fill gaps in existing fragment libraries.
Kutchukian PS; So SS; Fischer C; Waller CL
Methods Mol Biol; 2015; 1289():43-53. PubMed ID: 25709032
[TBL] [Abstract][Full Text] [Related]
9. Combining NMR and X-ray crystallography in fragment-based drug discovery: discovery of highly potent and selective BACE-1 inhibitors.
Wyss DF; Wang YS; Eaton HL; Strickland C; Voigt JH; Zhu Z; Stamford AW
Top Curr Chem; 2012; 317():83-114. PubMed ID: 21647837
[TBL] [Abstract][Full Text] [Related]
10. Fragment-Based Discovery of a Small Molecule Inhibitor of Bruton's Tyrosine Kinase.
Smith CR; Dougan DR; Komandla M; Kanouni T; Knight B; Lawson JD; Sabat M; Taylor ER; Vu P; Wyrick C
J Med Chem; 2015 Jul; 58(14):5437-44. PubMed ID: 26087137
[TBL] [Abstract][Full Text] [Related]
11. Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development of nM BACE-1 (beta-site APP cleaving enzyme 1) inhibitors.
Wang YS; Strickland C; Voigt JH; Kennedy ME; Beyer BM; Senior MM; Smith EM; Nechuta TL; Madison VS; Czarniecki M; McKittrick BA; Stamford AW; Parker EM; Hunter JC; Greenlee WJ; Wyss DF
J Med Chem; 2010 Feb; 53(3):942-50. PubMed ID: 20043700
[TBL] [Abstract][Full Text] [Related]
12. Kinase inhibitor data modeling and de novo inhibitor design with fragment approaches.
Vieth M; Erickson J; Wang J; Webster Y; Mader M; Higgs R; Watson I
J Med Chem; 2009 Oct; 52(20):6456-66. PubMed ID: 19791746
[TBL] [Abstract][Full Text] [Related]
13. Designing an orally available nontoxic p38 inhibitor with a fragment-based strategy.
Guarnieri F
Methods Mol Biol; 2015; 1289():211-26. PubMed ID: 25709042
[TBL] [Abstract][Full Text] [Related]
14. Fragment-based approaches and computer-aided drug discovery.
Rognan D
Top Curr Chem; 2012; 317():201-22. PubMed ID: 21710380
[TBL] [Abstract][Full Text] [Related]
15. Computational methods for fragment-based ligand design: growing and linking.
Bienstock RJ
Methods Mol Biol; 2015; 1289():119-35. PubMed ID: 25709037
[TBL] [Abstract][Full Text] [Related]
16. Novel strategy for three-dimensional fragment-based lead discovery.
Yuan H; Lu T; Ran T; Liu H; Lu S; Tai W; Leng Y; Zhang W; Wang J; Chen Y
J Chem Inf Model; 2011 Apr; 51(4):959-74. PubMed ID: 21438547
[TBL] [Abstract][Full Text] [Related]
17. Fragment-based lead discovery and design.
Joseph-McCarthy D; Campbell AJ; Kern G; Moustakas D
J Chem Inf Model; 2014 Mar; 54(3):693-704. PubMed ID: 24490951
[TBL] [Abstract][Full Text] [Related]
18. Fragment-based discovery of focal adhesion kinase inhibitors.
Grädler U; Bomke J; Musil D; Dresing V; Lehmann M; Hölzemann G; Greiner H; Esdar C; Krier M; Heinrich T
Bioorg Med Chem Lett; 2013 Oct; 23(19):5401-9. PubMed ID: 23973211
[TBL] [Abstract][Full Text] [Related]
19. Application of Free-Wilson selectivity analysis for combinatorial library design.
Sciabola S; Stanton RV; Johnson TL; Xi H
Methods Mol Biol; 2011; 685():91-109. PubMed ID: 20981520
[TBL] [Abstract][Full Text] [Related]
20. Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery.
Erlanson DA; Arndt JW; Cancilla MT; Cao K; Elling RA; English N; Friedman J; Hansen SK; Hession C; Joseph I; Kumaravel G; Lee WC; Lind KE; McDowell RS; Miatkowski K; Nguyen C; Nguyen TB; Park S; Pathan N; Penny DM; Romanowski MJ; Scott D; Silvian L; Simmons RL; Tangonan BT; Yang W; Sun L
Bioorg Med Chem Lett; 2011 May; 21(10):3078-83. PubMed ID: 21459573
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]