These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

297 related articles for article (PubMed ID: 25710492)

  • 41. Complex relationships between substrate sequence and sensitivity to alterations in γ-secretase processivity induced by γ-secretase modulators.
    Jung JI; Ran Y; Cruz PE; Rosario AM; Ladd TB; Kukar TL; Koo EH; Felsenstein KM; Golde TE
    Biochemistry; 2014 Apr; 53(12):1947-57. PubMed ID: 24620716
    [TBL] [Abstract][Full Text] [Related]  

  • 42. Differential effects between γ-secretase inhibitors and modulators on cognitive function in amyloid precursor protein-transgenic and nontransgenic mice.
    Mitani Y; Yarimizu J; Saita K; Uchino H; Akashiba H; Shitaka Y; Ni K; Matsuoka N
    J Neurosci; 2012 Feb; 32(6):2037-50. PubMed ID: 22323718
    [TBL] [Abstract][Full Text] [Related]  

  • 43. Cerebrolysin decreases amyloid-beta production by regulating amyloid protein precursor maturation in a transgenic model of Alzheimer's disease.
    Rockenstein E; Torrance M; Mante M; Adame A; Paulino A; Rose JB; Crews L; Moessler H; Masliah E
    J Neurosci Res; 2006 May; 83(7):1252-61. PubMed ID: 16511867
    [TBL] [Abstract][Full Text] [Related]  

  • 44. Activation of peroxisome proliferator-activated receptor α stimulates ADAM10-mediated proteolysis of APP.
    Corbett GT; Gonzalez FJ; Pahan K
    Proc Natl Acad Sci U S A; 2015 Jul; 112(27):8445-50. PubMed ID: 26080426
    [TBL] [Abstract][Full Text] [Related]  

  • 45. Pharmacodynamics of selective inhibition of γ-secretase by avagacestat.
    Albright CF; Dockens RC; Meredith JE; Olson RE; Slemmon R; Lentz KA; Wang JS; Denton RR; Pilcher G; Rhyne PW; Raybon JJ; Barten DM; Burton C; Toyn JH; Sankaranarayanan S; Polson C; Guss V; White R; Simutis F; Sanderson T; Gillman KW; Starrett JE; Bronson J; Sverdlov O; Huang SP; Castaneda L; Feldman H; Coric V; Zaczek R; Macor JE; Houston J; Berman RM; Tong G
    J Pharmacol Exp Ther; 2013 Mar; 344(3):686-95. PubMed ID: 23275065
    [TBL] [Abstract][Full Text] [Related]  

  • 46. BACE inhibitor reduces APP-beta-C-terminal fragment accumulation in axonal swellings of okadaic acid-induced neurodegeneration.
    Yoon SY; Choi JE; Yoon JH; Huh JW; Kim DH
    Neurobiol Dis; 2006 May; 22(2):435-44. PubMed ID: 16480887
    [TBL] [Abstract][Full Text] [Related]  

  • 47. Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavage.
    Teranishi Y; Inoue M; Yamamoto NG; Kihara T; Wiehager B; Ishikawa T; Winblad B; Schedin-Weiss S; Frykman S; Tjernberg LO
    FEBS J; 2015 Sep; 282(17):3438-51. PubMed ID: 26094765
    [TBL] [Abstract][Full Text] [Related]  

  • 48. Altered γ-Secretase Processing of APP Disrupts Lysosome and Autophagosome Function in Monogenic Alzheimer's Disease.
    Hung COY; Livesey FJ
    Cell Rep; 2018 Dec; 25(13):3647-3660.e2. PubMed ID: 30590039
    [TBL] [Abstract][Full Text] [Related]  

  • 49. Mitochondria are devoid of amyloid β-protein (Aβ)-producing secretases: Evidence for unlikely occurrence within mitochondria of Aβ generation from amyloid precursor protein.
    Mamada N; Tanokashira D; Ishii K; Tamaoka A; Araki W
    Biochem Biophys Res Commun; 2017 Apr; 486(2):321-328. PubMed ID: 28302486
    [TBL] [Abstract][Full Text] [Related]  

  • 50. Analysis of Non-Amyloidogenic Mutations in APP Supports Loss of Function Hypothesis of Alzheimer's Disease.
    Kim M; Bezprozvanny I
    Int J Mol Sci; 2023 Jan; 24(3):. PubMed ID: 36768421
    [TBL] [Abstract][Full Text] [Related]  

  • 51. Differential effects of familial Alzheimer's disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic activity.
    Schilling S; Pradhan A; Heesch A; Helbig A; Blennow K; Koch C; Bertgen L; Koo EH; Brinkmalm G; Zetterberg H; Kins S; Eggert S
    Acta Neuropathol Commun; 2023 Jun; 11(1):87. PubMed ID: 37259128
    [TBL] [Abstract][Full Text] [Related]  

  • 52. Depletion of the AD Risk Gene SORL1 Selectively Impairs Neuronal Endosomal Traffic Independent of Amyloidogenic APP Processing.
    Knupp A; Mishra S; Martinez R; Braggin JE; Szabo M; Kinoshita C; Hailey DW; Small SA; Jayadev S; Young JE
    Cell Rep; 2020 Jun; 31(9):107719. PubMed ID: 32492427
    [TBL] [Abstract][Full Text] [Related]  

  • 53. Advances in gamma-secretase modulation.
    Pissarnitski D
    Curr Opin Drug Discov Devel; 2007 Jul; 10(4):392-402. PubMed ID: 17659480
    [TBL] [Abstract][Full Text] [Related]  

  • 54. The role of membrane trafficking in the processing of amyloid precursor protein and production of amyloid peptides in Alzheimer's disease.
    Tan JZA; Gleeson PA
    Biochim Biophys Acta Biomembr; 2019 Apr; 1861(4):697-712. PubMed ID: 30639513
    [TBL] [Abstract][Full Text] [Related]  

  • 55. The contribution of activated astrocytes to Aβ production: implications for Alzheimer's disease pathogenesis.
    Zhao J; O'Connor T; Vassar R
    J Neuroinflammation; 2011 Nov; 8():150. PubMed ID: 22047170
    [TBL] [Abstract][Full Text] [Related]  

  • 56. Cellular Trafficking of Amyloid Precursor Protein in Amyloidogenesis Physiological and Pathological Significance.
    Mañucat-Tan NB; Saadipour K; Wang YJ; Bobrovskaya L; Zhou XF
    Mol Neurobiol; 2019 Feb; 56(2):812-830. PubMed ID: 29797184
    [TBL] [Abstract][Full Text] [Related]  

  • 57. Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein.
    Hook VY; Kindy M; Hook G
    J Biol Chem; 2008 Mar; 283(12):7745-53. PubMed ID: 18184658
    [TBL] [Abstract][Full Text] [Related]  

  • 58. Metabolic Characterization of Intact Cells Reveals Intracellular Amyloid Beta but Not Its Precursor Protein to Reduce Mitochondrial Respiration.
    Schaefer PM; von Einem B; Walther P; Calzia E; von Arnim CA
    PLoS One; 2016; 11(12):e0168157. PubMed ID: 28005987
    [TBL] [Abstract][Full Text] [Related]  

  • 59. η-Secretase processing of APP inhibits neuronal activity in the hippocampus.
    Willem M; Tahirovic S; Busche MA; Ovsepian SV; Chafai M; Kootar S; Hornburg D; Evans LD; Moore S; Daria A; Hampel H; Müller V; Giudici C; Nuscher B; Wenninger-Weinzierl A; Kremmer E; Heneka MT; Thal DR; Giedraitis V; Lannfelt L; Müller U; Livesey FJ; Meissner F; Herms J; Konnerth A; Marie H; Haass C
    Nature; 2015 Oct; 526(7573):443-7. PubMed ID: 26322584
    [TBL] [Abstract][Full Text] [Related]  

  • 60. Enzyme-substrate interface targeting by imidazole-based γ-secretase modulators activates γ-secretase and stabilizes its interaction with APP.
    Petit D; Hitzenberger M; Koch M; Lismont S; Zoltowska KM; Enzlein T; Hopf C; Zacharias M; Chávez-Gutiérrez L
    EMBO J; 2022 Nov; 41(21):e111084. PubMed ID: 36121025
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 15.