BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

308 related articles for article (PubMed ID: 25712099)

  • 1. Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex.
    Ekumi KM; Paculova H; Lenasi T; Pospichalova V; Bösken CA; Rybarikova J; Bryja V; Geyer M; Blazek D; Barboric M
    Nucleic Acids Res; 2015 Mar; 43(5):2575-89. PubMed ID: 25712099
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes.
    Blazek D; Kohoutek J; Bartholomeeusen K; Johansen E; Hulinkova P; Luo Z; Cimermancic P; Ule J; Peterlin BM
    Genes Dev; 2011 Oct; 25(20):2158-72. PubMed ID: 22012619
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Ovarian cancer-associated mutations disable catalytic activity of CDK12, a kinase that promotes homologous recombination repair and resistance to cisplatin and poly(ADP-ribose) polymerase inhibitors.
    Joshi PM; Sutor SL; Huntoon CJ; Karnitz LM
    J Biol Chem; 2014 Mar; 289(13):9247-53. PubMed ID: 24554720
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The structure and substrate specificity of human Cdk12/Cyclin K.
    Bösken CA; Farnung L; Hintermair C; Merzel Schachter M; Vogel-Bachmayr K; Blazek D; Anand K; Fisher RP; Eick D; Geyer M
    Nat Commun; 2014 Mar; 5():3505. PubMed ID: 24662513
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Role and therapeutic potential of CDK12 in human cancers.
    Chilà R; Guffanti F; Damia G
    Cancer Treat Rev; 2016 Nov; 50():83-88. PubMed ID: 27662623
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structures of the CDK12/CycK complex with AMP-PNP reveal a flexible C-terminal kinase extension important for ATP binding.
    Dixon-Clarke SE; Elkins JM; Cheng SW; Morin GB; Bullock AN
    Sci Rep; 2015 Nov; 5():17122. PubMed ID: 26597175
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Ovarian Cancers Harboring Inactivating Mutations in CDK12 Display a Distinct Genomic Instability Pattern Characterized by Large Tandem Duplications.
    Popova T; Manié E; Boeva V; Battistella A; Goundiam O; Smith NK; Mueller CR; Raynal V; Mariani O; Sastre-Garau X; Stern MH
    Cancer Res; 2016 Apr; 76(7):1882-91. PubMed ID: 26787835
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Expression, purification, and identification of associated proteins of the full-length hCDK12/CyclinK complex.
    Bartkowiak B; Greenleaf AL
    J Biol Chem; 2015 Jan; 290(3):1786-95. PubMed ID: 25429106
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II.
    Cheng SW; Kuzyk MA; Moradian A; Ichu TA; Chang VC; Tien JF; Vollett SE; Griffith M; Marra MA; Morin GB
    Mol Cell Biol; 2012 Nov; 32(22):4691-704. PubMed ID: 22988298
    [TBL] [Abstract][Full Text] [Related]  

  • 10. CDK12 regulates DNA repair genes by suppressing intronic polyadenylation.
    Dubbury SJ; Boutz PL; Sharp PA
    Nature; 2018 Dec; 564(7734):141-145. PubMed ID: 30487607
    [TBL] [Abstract][Full Text] [Related]  

  • 11. CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability.
    Choi SH; Martinez TF; Kim S; Donaldson C; Shokhirev MN; Saghatelian A; Jones KA
    Genes Dev; 2019 Apr; 33(7-8):418-435. PubMed ID: 30819820
    [TBL] [Abstract][Full Text] [Related]  

  • 12. CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes.
    Chirackal Manavalan AP; Pilarova K; Kluge M; Bartholomeeusen K; Rajecky M; Oppelt J; Khirsariya P; Paruch K; Krejci L; Friedel CC; Blazek D
    EMBO Rep; 2019 Sep; 20(9):e47592. PubMed ID: 31347271
    [TBL] [Abstract][Full Text] [Related]  

  • 13. P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA.
    Lin X; Taube R; Fujinaga K; Peterlin BM
    J Biol Chem; 2002 May; 277(19):16873-8. PubMed ID: 11884399
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Systematic Characterization of Recurrent Genomic Alterations in Cyclin-Dependent Kinases Reveals Potential Therapeutic Strategies for Cancer Treatment.
    Shan W; Yuan J; Hu Z; Jiang J; Wang Y; Loo N; Fan L; Tang Z; Zhang T; Xu M; Pan Y; Lu J; Long M; Tanyi JL; Montone KT; Fan Y; Hu X; Zhang Y; Zhang L
    Cell Rep; 2020 Jul; 32(2):107884. PubMed ID: 32668240
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Inactivation of CDK12 Delineates a Distinct Immunogenic Class of Advanced Prostate Cancer.
    Wu YM; Cieślik M; Lonigro RJ; Vats P; Reimers MA; Cao X; Ning Y; Wang L; Kunju LP; de Sarkar N; Heath EI; Chou J; Feng FY; Nelson PS; de Bono JS; Zou W; Montgomery B; Alva A; ; Robinson DR; Chinnaiyan AM
    Cell; 2018 Jun; 173(7):1770-1782.e14. PubMed ID: 29906450
    [TBL] [Abstract][Full Text] [Related]  

  • 16. CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation.
    Krajewska M; Dries R; Grassetti AV; Dust S; Gao Y; Huang H; Sharma B; Day DS; Kwiatkowski N; Pomaville M; Dodd O; Chipumuro E; Zhang T; Greenleaf AL; Yuan GC; Gray NS; Young RA; Geyer M; Gerber SA; George RE
    Nat Commun; 2019 Apr; 10(1):1757. PubMed ID: 30988284
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structural Mass Spectrometry Probes the Inhibitor-Induced Allosteric Activation of CDK12/CDK13-Cyclin K Dissociation.
    Bai Y; Liu Z; Li Y; Zhao H; Lai C; Zhao S; Chen K; Luo C; Yang X; Wang F
    J Am Chem Soc; 2023 May; 145(21):11477-11481. PubMed ID: 37207290
    [TBL] [Abstract][Full Text] [Related]  

  • 18. CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1.
    Bartkowiak B; Liu P; Phatnani HP; Fuda NJ; Cooper JJ; Price DH; Adelman K; Lis JT; Greenleaf AL
    Genes Dev; 2010 Oct; 24(20):2303-16. PubMed ID: 20952539
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Cyclin K inhibits HIV-1 gene expression and replication by interfering with cyclin-dependent kinase 9 (CDK9)-cyclin T1 interaction in Nef-dependent manner.
    Khan SZ; Mitra D
    J Biol Chem; 2011 Jul; 286(26):22943-54. PubMed ID: 21555514
    [TBL] [Abstract][Full Text] [Related]  

  • 20. [Function of CDK12 in Tumor initiation and progression and its clinical consequences].
    Vrábel D; Svoboda M; Navrátil J; Kohoutek J
    Klin Onkol; 2014; 27(5):340-6. PubMed ID: 25312711
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.