BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

199 related articles for article (PubMed ID: 25730262)

  • 21. A cluster of protein kinases and phosphatases modulated in fetal Down syndrome (trisomy 21) brain.
    Weitzdoerfer R; Toran N; Subramaniyan S; Pollak A; Dierssen M; Lubec G
    Amino Acids; 2015 Jun; 47(6):1127-34. PubMed ID: 25740605
    [TBL] [Abstract][Full Text] [Related]  

  • 22. A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication.
    Wang P; Alvarez-Perez JC; Felsenfeld DP; Liu H; Sivendran S; Bender A; Kumar A; Sanchez R; Scott DK; Garcia-Ocaña A; Stewart AF
    Nat Med; 2015 Apr; 21(4):383-8. PubMed ID: 25751815
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Increased cortical synaptic activation of TrkB and downstream signaling markers in a mouse model of Down Syndrome.
    Nosheny RL; Belichenko PV; Busse BL; Weissmiller AM; Dang V; Das D; Fahimi A; Salehi A; Smith SJ; Mobley WC
    Neurobiol Dis; 2015 May; 77():173-90. PubMed ID: 25753471
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Reversing excitatory GABAAR signaling restores synaptic plasticity and memory in a mouse model of Down syndrome.
    Deidda G; Parrini M; Naskar S; Bozarth IF; Contestabile A; Cancedda L
    Nat Med; 2015 Apr; 21(4):318-26. PubMed ID: 25774849
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Protein dynamics associated with failed and rescued learning in the Ts65Dn mouse model of Down syndrome.
    Ahmed MM; Dhanasekaran AR; Block A; Tong S; Costa AC; Stasko M; Gardiner KJ
    PLoS One; 2015; 10(3):e0119491. PubMed ID: 25793384
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Disruption of neurogenesis and cortical development in transgenic mice misexpressing Olig2, a gene in the Down syndrome critical region.
    Liu W; Zhou H; Liu L; Zhao C; Deng Y; Chen L; Wu L; Mandrycky N; McNabb CT; Peng Y; Fuchs PN; Lu J; Sheen V; Qiu M; Mao M; Lu QR
    Neurobiol Dis; 2015 May; 77():106-16. PubMed ID: 25747816
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis.
    Kettle JG; Ballard P; Bardelle C; Cockerill M; Colclough N; Critchlow SE; Debreczeni J; Fairley G; Fillery S; Graham MA; Goodwin L; Guichard S; Hudson K; Ward RA; Whittaker D
    J Med Chem; 2015 Mar; 58(6):2834-44. PubMed ID: 25738750
    [TBL] [Abstract][Full Text] [Related]  

  • 28. The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells.
    Khor B; Gagnon JD; Goel G; Roche MI; Conway KL; Tran K; Aldrich LN; Sundberg TB; Paterson AM; Mordecai S; Dombkowski D; Schirmer M; Tan PH; Bhan AK; Roychoudhuri R; Restifo NP; O'Shea JJ; Medoff BD; Shamji AF; Schreiber SL; Sharpe AH; Shaw SY; Xavier RJ
    Elife; 2015 May; 4():. PubMed ID: 25998054
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.
    Chen P; Chaikuad A; Bamborough P; Bantscheff M; Bountra C; Chung CW; Fedorov O; Grandi P; Jung D; Lesniak R; Lindon M; Müller S; Philpott M; Prinjha R; Rogers C; Selenski C; Tallant C; Werner T; Willson TM; Knapp S; Drewry DH
    J Med Chem; 2016 Feb; 59(4):1410-24. PubMed ID: 25799074
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Fish oil improves gene targets of Down syndrome in C57BL and BALB/c mice.
    Zmijewski PA; Gao LY; Saxena AR; Chavannes NK; Hushmendy SF; Bhoiwala DL; Crawford DR
    Nutr Res; 2015 May; 35(5):440-8. PubMed ID: 25799055
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Global differential expression of genes located in the Down Syndrome Critical Region in normal human brain.
    Montoya JC; Fajardo D; Peña A; Sánchez A; Domínguez MC; Satizábal JM; García-Vallejo F
    Colomb Med (Cali); 2014; 45(4):154-61. PubMed ID: 25767303
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF.
    Bennett J; Fedorov O; Tallant C; Monteiro O; Meier J; Gamble V; Savitsky P; Nunez-Alonso GA; Haendler B; Rogers C; Brennan PE; Müller S; Knapp S
    J Med Chem; 2016 Feb; 59(4):1642-7. PubMed ID: 25974391
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Selective Inhibitors of Cyclin G Associated Kinase (GAK) as Anti-Hepatitis C Agents.
    Kovackova S; Chang L; Bekerman E; Neveu G; Barouch-Bentov R; Chaikuad A; Heroven C; Šála M; De Jonghe S; Knapp S; Einav S; Herdewijn P
    J Med Chem; 2015 Apr; 58(8):3393-410. PubMed ID: 25822739
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Luciferin and derivatives as a DYRK selective scaffold for the design of protein kinase inhibitors.
    Rothweiler U; Eriksson J; Stensen W; Leeson F; Engh RA; Svendsen JS
    Eur J Med Chem; 2015 Apr; 94():140-8. PubMed ID: 25768698
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Design and synthesis of a potent inhibitor of class 1 DYRK kinases as a suppressor of adipogenesis.
    Masaki S; Kii I; Sumida Y; Kato-Sumida T; Ogawa Y; Ito N; Nakamura M; Sonamoto R; Kataoka N; Hosoya T; Hagiwara M
    Bioorg Med Chem; 2015 Aug; 23(15):4434-4441. PubMed ID: 26145823
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Opposite phenotypes of muscle strength and locomotor function in mouse models of partial trisomy and monosomy 21 for the proximal Hspa13-App region.
    Brault V; Duchon A; Romestaing C; Sahun I; Pothion S; Karout M; Borel C; Dembele D; Bizot JC; Messaddeq N; Sharp AJ; Roussel D; Antonarakis SE; Dierssen M; Hérault Y
    PLoS Genet; 2015 Mar; 11(3):e1005062. PubMed ID: 25803843
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Allocentric spatial learning and memory deficits in Down syndrome.
    Lavenex PB; Bostelmann M; Brandner C; Costanzo F; Fragnière E; Klencklen G; Lavenex P; Menghini D; Vicari S
    Front Psychol; 2015; 6():62. PubMed ID: 25762946
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Hologram QSAR models of a series of 6-arylquinazolin-4-amine inhibitors of a new Alzheimer's disease target: dual specificity tyrosine-phosphorylation-regulated kinase-1A enzyme.
    Leal FD; da Silva Lima CH; de Alencastro RB; Castro HC; Rodrigues CR; Albuquerque MG
    Int J Mol Sci; 2015 Mar; 16(3):5235-53. PubMed ID: 25756379
    [TBL] [Abstract][Full Text] [Related]  

  • 39. DYRK protein kinases.
    Soppa U; Becker W
    Curr Biol; 2015 Jun; 25(12):R488-9. PubMed ID: 26079075
    [TBL] [Abstract][Full Text] [Related]  

  • 40. The structure of a dual-specificity tyrosine phosphorylation-regulated kinase 1A-PKC412 complex reveals disulfide-bridge formation with the anomalous catalytic loop HRD(HCD) cysteine.
    Alexeeva M; Åberg E; Engh RA; Rothweiler U
    Acta Crystallogr D Biol Crystallogr; 2015 May; 71(Pt 5):1207-15. PubMed ID: 25945585
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 10.