BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

208 related articles for article (PubMed ID: 25733891)

  • 1. Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics.
    Balzarini J; Das K; Bernatchez JA; Martinez SE; Ngure M; Keane S; Ford A; Maguire N; Mullins N; John J; Kim Y; Dehaen W; Vande Voorde J; Liekens S; Naesens L; Götte M; Maguire AR; Arnold E
    Proc Natl Acad Sci U S A; 2015 Mar; 112(11):3475-80. PubMed ID: 25733891
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Guanine α-carboxy nucleoside phosphonate (G-α-CNP) shows a different inhibitory kinetic profile against the DNA polymerases of human immunodeficiency virus (HIV) and herpes viruses.
    Balzarini J; Menni M; Das K; van Berckelaer L; Ford A; Maguire NM; Liekens S; Boehmer PE; Arnold E; Götte M; Maguire AR
    Biochem Pharmacol; 2017 Jul; 136():51-61. PubMed ID: 28390939
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Exploring the role of the α-carboxyphosphonate moiety in the HIV-RT activity of α-carboxy nucleoside phosphonates.
    Mullins ND; Maguire NM; Ford A; Das K; Arnold E; Balzarini J; Maguire AR
    Org Biomol Chem; 2016 Feb; 14(8):2454-65. PubMed ID: 26813581
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Alpha-carboxynucleoside phosphonates: direct-acting inhibitors of viral DNA polymerases.
    Balzarini J; Ford A; Maguire NM; John J; Das K; Arnold E; Dehaen W; Maguire A
    Future Med Chem; 2019 Jan; 11(2):137-154. PubMed ID: 30648904
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Design and synthesis of α-carboxy nucleoside phosphonate analogues and evaluation as HIV-1 reverse transcriptase-targeting agents.
    Keane SJ; Ford A; Mullins ND; Maguire NM; Legigan T; Balzarini J; Maguire AR
    J Org Chem; 2015 Mar; 80(5):2479-93. PubMed ID: 25532055
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Mechanisms of resistance to nucleoside analogue inhibitors of HIV-1 reverse transcriptase.
    Menéndez-Arias L
    Virus Res; 2008 Jun; 134(1-2):124-46. PubMed ID: 18272247
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Pronounced Inhibition Shift from HIV Reverse Transcriptase to Herpetic DNA Polymerases by Increasing the Flexibility of α-Carboxy Nucleoside Phosphonates.
    John J; Kim Y; Bennett N; Das K; Liekens S; Naesens L; Arnold E; Maguire AR; Götte M; Dehaen W; Balzarini J
    J Med Chem; 2015 Oct; 58(20):8110-27. PubMed ID: 26450273
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Membrane Permeable, Bioreversibly Modified Prodrugs of Nucleoside Diphosphate-γ-Phosphonates.
    Jia X; Weber S; Schols D; Meier C
    J Med Chem; 2020 Oct; 63(20):11990-12007. PubMed ID: 32991174
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Biochemical and mechanistic basis for the activity of nucleoside analogue inhibitors of HIV reverse transcriptase.
    Painter GR; Almond MR; Mao S; Liotta DC
    Curr Top Med Chem; 2004; 4(10):1035-44. PubMed ID: 15193137
    [TBL] [Abstract][Full Text] [Related]  

  • 10. In vitro suppression of K65R reverse transcriptase-mediated tenofovir- and adefovir-5'-diphosphate resistance conferred by the boranophosphonate derivatives.
    Frangeul A; Barral K; Alvarez K; Canard B
    Antimicrob Agents Chemother; 2007 Sep; 51(9):3162-7. PubMed ID: 17620380
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Stereospecificity of human DNA polymerases alpha, beta, gamma, delta and epsilon, HIV-reverse transcriptase, HSV-1 DNA polymerase, calf thymus terminal transferase and Escherichia coli DNA polymerase I in recognizing D- and L-thymidine 5'-triphosphate as substrate.
    Focher F; Maga G; Bendiscioli A; Capobianco M; Colonna F; Garbesi A; Spadari S
    Nucleic Acids Res; 1995 Aug; 23(15):2840-7. PubMed ID: 7544886
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Coordination Chemistry of Nucleotides and Antivirally Active Acyclic Nucleoside Phosphonates, including Mechanistic Considerations.
    Sigel A; Sigel H; Sigel RKO
    Molecules; 2022 Apr; 27(9):. PubMed ID: 35565975
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Nucleoside-analog resistance mutations in HIV-1 reverse transcriptase and their influence on polymerase fidelity and viral mutation rates.
    Rezende LF; Prasad VR
    Int J Biochem Cell Biol; 2004 Sep; 36(9):1716-34. PubMed ID: 15183340
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Gln151 of HIV-1 reverse transcriptase acts as a steric gate towards clinically relevant acyclic phosphonate nucleotide analogues.
    Frangeul A; Bussetta C; Deval J; Barral K; Alvarez K; Canard B
    Antivir Ther; 2008; 13(1):115-24. PubMed ID: 18389906
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Newly synthesized L-enantiomers of 3'-fluoro-modified beta-2'-deoxyribonucleoside 5'-triphosphates inhibit hepatitis B DNA polymerases but not the five cellular DNA polymerases alpha, beta, gamma, delta, and epsilon nor HIV-1 reverse transcriptase.
    von Janta-Lipinski M; Costisella B; Ochs H; Hübscher U; Hafkemeyer P; Matthes E
    J Med Chem; 1998 Jun; 41(12):2040-6. PubMed ID: 9622545
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis of Guanine α-Carboxy Nucleoside Phosphonate (G-α-CNP), a Direct Inhibitor of Multiple Viral DNA Polymerases.
    Maguire NM; Ford A; Balzarini J; Maguire AR
    J Org Chem; 2018 Sep; 83(17):10510-10517. PubMed ID: 30084243
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A Bifunctional Nucleoside Probe for the Inhibition of the Human Immunodeficiency Virus-Type 1 Reverse Transcriptase.
    Shaw TA; Ablenas CJ; Desrochers GF; Powdrill MH; Bilodeau DA; Vincent-Rocan JF; Niu M; Monette A; Mouland AJ; Beauchemin AM; Pezacki JP
    Bioconjug Chem; 2020 May; 31(5):1537-1544. PubMed ID: 32259429
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase.
    Gao HQ; Boyer PL; Sarafianos SG; Arnold E; Hughes SH
    J Mol Biol; 2000 Jul; 300(2):403-18. PubMed ID: 10873473
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Intracellular interactions between nucleos(t)ide inhibitors of HIV reverse transcriptase.
    Ray AS
    AIDS Rev; 2005; 7(2):113-25. PubMed ID: 16092505
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structural and biochemical effects of human immunodeficiency virus mutants resistant to non-nucleoside reverse transcriptase inhibitors.
    Domaoal RA; Demeter LM
    Int J Biochem Cell Biol; 2004 Sep; 36(9):1735-51. PubMed ID: 15183341
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.