These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

163 related articles for article (PubMed ID: 25744034)

  • 1. Stereochemical bias introduced during RNA synthesis modulates the activity of phosphorothioate siRNAs.
    Jahns H; Roos M; Imig J; Baumann F; Wang Y; Gilmour R; Hall J
    Nat Commun; 2015 Mar; 6():6317. PubMed ID: 25744034
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Chirality matters: stereo-defined phosphorothioate linkages at the termini of small interfering RNAs improve pharmacology in vivo.
    Jahns H; Taneja N; Willoughby JLS; Akabane-Nakata M; Brown CR; Nguyen T; Bisbe A; Matsuda S; Hettinger M; Manoharan RM; Rajeev KG; Maier MA; Zlatev I; Charisse K; Egli M; Manoharan M
    Nucleic Acids Res; 2022 Feb; 50(3):1221-1240. PubMed ID: 34268578
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Stereocontrolled synthesis of oligoribonucleoside phosphorothioates by an oxazaphospholidine approach.
    Oka N; Kondo T; Fujiwara S; Maizuru Y; Wada T
    Org Lett; 2009 Feb; 11(4):967-70. PubMed ID: 19159256
    [TBL] [Abstract][Full Text] [Related]  

  • 4. RNA interference induced by siRNAs modified with 4'-thioribonucleosides in cultured mammalian cells.
    Hoshika S; Minakawa N; Kamiya H; Harashima H; Matsuda A
    FEBS Lett; 2005 Jun; 579(14):3115-8. PubMed ID: 15919084
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Identification of a Tricyclic P
    Sakamuri S; Liu D; Eltepu L; Liu B; Reboton LJ; Preston R; Bradshaw CW
    Chembiochem; 2020 May; 21(9):1298-1303. PubMed ID: 31863718
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Gene-silencing properties of siRNAs that contain internal amide-bond linkages.
    Gong W; Desaulniers JP
    Bioorg Med Chem Lett; 2012 Nov; 22(22):6934-7. PubMed ID: 23062704
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and cellular activity of stereochemically-pure 2'-O-(2-methoxyethyl)-phosphorothioate oligonucleotides.
    Li M; Lightfoot HL; Halloy F; Malinowska AL; Berk C; Behera A; Schümperli D; Hall J
    Chem Commun (Camb); 2017 Jan; 53(3):541-544. PubMed ID: 27966701
    [TBL] [Abstract][Full Text] [Related]  

  • 8. RNA interference using boranophosphate siRNAs: structure-activity relationships.
    Hall AH; Wan J; Shaughnessy EE; Ramsay Shaw B; Alexander KA
    Nucleic Acids Res; 2004; 32(20):5991-6000. PubMed ID: 15545637
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Stereocontrolled Solid-Phase Synthesis of Phosphate/Phosphorothioate (PO/PS) Chimeric Oligodeoxyribonucleotides on an Automated Synthesizer Using an Oxazaphospholidine-Phosphoramidite Method.
    Nukaga Y; Oka N; Wada T
    J Org Chem; 2016 Apr; 81(7):2753-62. PubMed ID: 26939010
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Stereocontrolled solid-phase synthesis of phosphorothioate oligoribonucleotides using 2'-O-(2-cyanoethoxymethyl)-nucleoside 3'-O-oxazaphospholidine monomers.
    Nukaga Y; Yamada K; Ogata T; Oka N; Wada T
    J Org Chem; 2012 Sep; 77(18):7913-22. PubMed ID: 22931131
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The role of the Hint1 protein in the metabolism of phosphorothioate oligonucleotides drugs and prodrugs, and the release of H
    Krakowiak A; Piotrzkowska D; Kocoń-Rębowska B; Kaczmarek R; Maciaszek A
    Biochem Pharmacol; 2019 May; 163():250-259. PubMed ID: 30772266
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Evaluation of siRNAs that contain internal variable-length spacer linkages.
    Efthymiou TC; Peel B; Huynh V; Desaulniers JP
    Bioorg Med Chem Lett; 2012 Sep; 22(17):5590-4. PubMed ID: 22850216
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and biological activity of phosphonoacetate- and thiophosphonoacetate-modified 2'-O-methyl oligoribonucleotides.
    Threlfall RN; Torres AG; Krivenko A; Gait MJ; Caruthers MH
    Org Biomol Chem; 2012 Jan; 10(4):746-54. PubMed ID: 22124653
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Separation of RNA phosphorothioate oligonucleotides by HPLC.
    Frederiksen JK; Piccirilli JA
    Methods Enzymol; 2009; 468():289-309. PubMed ID: 20946775
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Impact of Phosphorothioate Chirality on Double-Stranded siRNAs: A Systematic Evaluation of Stereopure siRNA Designs.
    Sakamuri S; Eltepu L; Liu D; Lam S; Meade BR; Liu B; Dello Iacono G; Kabakibi A; Luukkonen L; Leedom T; Foster M; Bradshaw CW
    Chembiochem; 2020 May; 21(9):1304-1308. PubMed ID: 31863714
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Effects on RNA interference in gene expression (RNAi) in cultured mammalian cells of mismatches and the introduction of chemical modifications at the 3'-ends of siRNAs.
    Hamada M; Ohtsuka T; Kawaida R; Koizumi M; Morita K; Furukawa H; Imanishi T; Miyagishi M; Taira K
    Antisense Nucleic Acid Drug Dev; 2002 Oct; 12(5):301-9. PubMed ID: 12477280
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Biodistribution of phosphodiester and phosphorothioate siRNA.
    Braasch DA; Paroo Z; Constantinescu A; Ren G; Oz OK; Mason RP; Corey DR
    Bioorg Med Chem Lett; 2004 Mar; 14(5):1139-43. PubMed ID: 14980652
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis, characterization, and biological properties of small branched RNA fragments containing chiral (Rp and Sp) 2',5'-phosphorothioate linkages.
    Mourani R; Damha MJ
    Nucleosides Nucleotides Nucleic Acids; 2006; 25(2):203-29. PubMed ID: 16541962
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Competition potency of siRNA is specified by the 5'-half sequence of the guide strand.
    Yoo JW; Kim S; Lee DK
    Biochem Biophys Res Commun; 2008 Feb; 367(1):78-83. PubMed ID: 18164261
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis and silencing properties of siRNAs possessing lipophilic groups at their 3'-termini.
    Ueno Y; Kawada K; Shibata A; Yoshikawa K; Wataya Y; Kitade Y
    Nucleic Acids Symp Ser (Oxf); 2008; (52):503-4. PubMed ID: 18776474
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.