BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

340 related articles for article (PubMed ID: 25744542)

  • 1. The future of EPAC-targeted therapies: agonism versus antagonism.
    Parnell E; Palmer TM; Yarwood SJ
    Trends Pharmacol Sci; 2015 Apr; 36(4):203-14. PubMed ID: 25744542
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Novel Epac fluorescent ligand reveals distinct Epac1 vs. Epac2 distribution and function in cardiomyocytes.
    Pereira L; Rehmann H; Lao DH; Erickson JR; Bossuyt J; Chen J; Bers DM
    Proc Natl Acad Sci U S A; 2015 Mar; 112(13):3991-6. PubMed ID: 25829540
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The (R)-enantiomer of CE3F4 is a preferential inhibitor of human exchange protein directly activated by cyclic AMP isoform 1 (Epac1).
    Courilleau D; Bouyssou P; Fischmeister R; Lezoualc'h F; Blondeau JP
    Biochem Biophys Res Commun; 2013 Oct; 440(3):443-8. PubMed ID: 24099776
    [TBL] [Abstract][Full Text] [Related]  

  • 4. EPAC activation inhibits acetaldehyde-induced activation and proliferation of hepatic stellate cell via Rap1.
    Yang Y; Yang F; Wu X; Lv X; Li J
    Can J Physiol Pharmacol; 2016 May; 94(5):498-507. PubMed ID: 26854595
    [TBL] [Abstract][Full Text] [Related]  

  • 5. cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells.
    Kang G; Chepurny OG; Malester B; Rindler MJ; Rehmann H; Bos JL; Schwede F; Coetzee WA; Holz GG
    J Physiol; 2006 Jun; 573(Pt 3):595-609. PubMed ID: 16613879
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Isoform-specific antagonists of exchange proteins directly activated by cAMP.
    Tsalkova T; Mei FC; Li S; Chepurny OG; Leech CA; Liu T; Holz GG; Woods VL; Cheng X
    Proc Natl Acad Sci U S A; 2012 Nov; 109(45):18613-8. PubMed ID: 23091014
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and Biochemical Evaluation of Noncyclic Nucleotide Exchange Proteins Directly Activated by cAMP 1 (EPAC1) Regulators.
    Wang P; Luchowska-Stańska U; van Basten B; Chen H; Liu Z; Wiejak J; Whelan P; Morgan D; Lochhead E; Barker G; Rehmann H; Yarwood SJ; Zhou J
    J Med Chem; 2020 May; 63(10):5159-5184. PubMed ID: 32340447
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Identification and validation of modulators of exchange protein activated by cAMP (Epac) activity: structure-function implications for Epac activation and inhibition.
    Brown LM; Rogers KE; McCammon JA; Insel PA
    J Biol Chem; 2014 Mar; 289(12):8217-30. PubMed ID: 24497631
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Elevated cAMP Protects against Diclofenac-Induced Toxicity in Primary Rat Hepatocytes: A Protective Effect Mediated by the Exchange Protein Directly Activated by cAMP/cAMP-Regulated Guanine Nucleotide Exchange Factors.
    Aguilar Mora FA; Musheshe N; Oun A; Buist-Homan M; Lezoualc'h F; Cheng X; Schmidt M; Moshage H
    Mol Pharmacol; 2021 Apr; 99(4):294-307. PubMed ID: 33574047
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Origin and Isoform Specific Functions of Exchange Proteins Directly Activated by cAMP: A Phylogenetic Analysis.
    Ni Z; Cheng X
    Cells; 2021 Oct; 10(10):. PubMed ID: 34685730
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Broad Impact of Exchange Protein Directly Activated by cAMP 2 (EPAC2) on Respiratory Viral Infections.
    Choi EJ; Wu W; Cong X; Zhang K; Luo J; Ye S; Wang P; Suresh A; Ullah UM; Zhou J; Bao X
    Viruses; 2021 Jun; 13(6):. PubMed ID: 34205489
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Cell physiology of cAMP sensor Epac.
    Holz GG; Kang G; Harbeck M; Roe MW; Chepurny OG
    J Physiol; 2006 Nov; 577(Pt 1):5-15. PubMed ID: 16973695
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Exchange protein directly activated by cAMP (Epac) protects against airway inflammation and airway remodeling in asthmatic mice.
    Chen YF; Huang G; Wang YM; Cheng M; Zhu FF; Zhong JN; Gao YD
    Respir Res; 2019 Dec; 20(1):285. PubMed ID: 31852500
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Interaction of Epac with Non-canonical Cyclic Nucleotides.
    Rehmann H
    Handb Exp Pharmacol; 2017; 238():135-147. PubMed ID: 27900608
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Cyclic nucleotide signalling: a molecular approach to drug discovery for Alzheimer's disease.
    McPhee I; Gibson LC; Kewney J; Darroch C; Stevens PA; Spinks D; Cooreman A; MacKenzie SJ
    Biochem Soc Trans; 2005 Dec; 33(Pt 6):1330-2. PubMed ID: 16246111
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Epac: defining a new mechanism for cAMP action.
    Gloerich M; Bos JL
    Annu Rev Pharmacol Toxicol; 2010; 50():355-75. PubMed ID: 20055708
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Cyclic adenosine 3',5'-monophosphate (cAMP)-dependent protein kinases, but not exchange proteins directly activated by cAMP (Epac), mediate thyrotropin/cAMP-dependent regulation of thyroid cells.
    Dremier S; Milenkovic M; Blancquaert S; Dumont JE; Døskeland SO; Maenhaut C; Roger PP
    Endocrinology; 2007 Oct; 148(10):4612-22. PubMed ID: 17584967
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs.
    de Rooij J; Rehmann H; van Triest M; Cool RH; Wittinghofer A; Bos JL
    J Biol Chem; 2000 Jul; 275(27):20829-36. PubMed ID: 10777494
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Differential Pharmacophore Definition of the cAMP Binding Sites of Neuritogenic cAMP Sensor-Rapgef2, Protein Kinase A, and Exchange Protein Activated by cAMP in Neuroendocrine Cells Using an Adenine-Based Scaffold.
    Emery AC; Alvarez RA; Eiden MV; Xu W; Siméon FG; Eiden LE
    ACS Chem Neurosci; 2017 Jul; 8(7):1500-1509. PubMed ID: 28290664
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Prostaglandin E2-activated Epac promotes neointimal formation of the rat ductus arteriosus by a process distinct from that of cAMP-dependent protein kinase A.
    Yokoyama U; Minamisawa S; Quan H; Akaike T; Suzuki S; Jin M; Jiao Q; Watanabe M; Otsu K; Iwasaki S; Nishimaki S; Sato M; Ishikawa Y
    J Biol Chem; 2008 Oct; 283(42):28702-9. PubMed ID: 18697745
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 17.