223 related articles for article (PubMed ID: 25765759)
1. Novel series of benzoquinones with high potency against 5-lipoxygenase in human polymorphonuclear leukocytes.
Filosa R; Peduto A; Schaible AM; Krauth V; Weinigel C; Barz D; Petronzi C; Bruno F; Roviezzo F; Spaziano G; D'Agostino B; De Rosa M; Werz O
Eur J Med Chem; 2015 Apr; 94():132-9. PubMed ID: 25765759
[TBL] [Abstract][Full Text] [Related]
2. Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin.
Schaible AM; Traber H; Temml V; Noha SM; Filosa R; Peduto A; Weinigel C; Barz D; Schuster D; Werz O
Biochem Pharmacol; 2013 Aug; 86(4):476-86. PubMed ID: 23623753
[TBL] [Abstract][Full Text] [Related]
3. Identification of 2-mercaptohexanoic acids as dual inhibitors of 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1.
Greiner C; Zettl H; Koeberle A; Pergola C; Northoff H; Schubert-Zsilavecz M; Werz O
Bioorg Med Chem; 2011 Jun; 19(11):3394-401. PubMed ID: 21570310
[TBL] [Abstract][Full Text] [Related]
4. Discovery and biological evaluation of novel 1,4-benzoquinone and related resorcinol derivatives that inhibit 5-lipoxygenase.
Filosa R; Peduto A; Aparoy P; Schaible AM; Luderer S; Krauth V; Petronzi C; Massa A; de Rosa M; Reddanna P; Werz O
Eur J Med Chem; 2013 Sep; 67():269-79. PubMed ID: 23871907
[TBL] [Abstract][Full Text] [Related]
5. Synthesis and biological evaluation of novel myrtucommulones and structural analogues that target mPGES-1 and 5-lipoxygenase.
Wiechmann K; Müller H; Huch V; Hartmann D; Werz O; Jauch J
Eur J Med Chem; 2015 Aug; 101():133-49. PubMed ID: 26123643
[TBL] [Abstract][Full Text] [Related]
6. A novel class of dual mPGES-1/5-LO inhibitors based on the α-naphthyl pirinixic acid scaffold.
Hieke M; Greiner C; Thieme TM; Schubert-Zsilavecz M; Werz O; Zettl H
Bioorg Med Chem Lett; 2011 Mar; 21(5):1329-33. PubMed ID: 21310608
[TBL] [Abstract][Full Text] [Related]
7. Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo.
Hanke T; Dehm F; Liening S; Popella SD; Maczewsky J; Pillong M; Kunze J; Weinigel C; Barz D; Kaiser A; Wurglics M; Lämmerhofer M; Schneider G; Sautebin L; Schubert-Zsilavecz M; Werz O
J Med Chem; 2013 Nov; 56(22):9031-44. PubMed ID: 24171493
[TBL] [Abstract][Full Text] [Related]
8. Munronia pinnata (Wall.) Theob.: unveiling phytochemistry and dual inhibition of 5-lipoxygenase and microsomal prostaglandin E2 synthase (mPGES)-1.
Napagoda M; Gerstmeier J; Koeberle A; Wesely S; Popella S; Lorenz S; Scheubert K; Böcker S; Svatoš A; Werz O
J Ethnopharmacol; 2014 Feb; 151(2):882-90. PubMed ID: 24315851
[TBL] [Abstract][Full Text] [Related]
9. Optimization of benzoquinone and hydroquinone derivatives as potent inhibitors of human 5-lipoxygenase.
Peduto A; Scuotto M; Krauth V; Roviezzo F; Rossi A; Temml V; Esposito V; Stuppner H; Schuster D; D'Agostino B; Schiraldi C; de Rosa M; Werz O; Filosa R
Eur J Med Chem; 2017 Feb; 127():715-726. PubMed ID: 27836196
[TBL] [Abstract][Full Text] [Related]
10. Design and synthesis of a second series of triazole-based compounds as potent dual mPGES-1 and 5-lipoxygenase inhibitors.
Chini MG; De Simone R; Bruno I; Riccio R; Dehm F; Weinigel C; Barz D; Werz O; Bifulco G
Eur J Med Chem; 2012 Aug; 54():311-23. PubMed ID: 22683242
[TBL] [Abstract][Full Text] [Related]
11. Discovery and biological evaluation of a novel class of dual microsomal prostaglandin E2 synthase-1/5-lipoxygenase inhibitors based on 2-[(4,6-diphenethoxypyrimidin-2-yl)thio]hexanoic acid.
Hieke M; Greiner C; Dittrich M; Reisen F; Schneider G; Schubert-Zsilavecz M; Werz O
J Med Chem; 2011 Jul; 54(13):4490-507. PubMed ID: 21591611
[TBL] [Abstract][Full Text] [Related]
12. The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo.
Schaible AM; Filosa R; Krauth V; Temml V; Pace S; Garscha U; Liening S; Weinigel C; Rummler S; Schieferdecker S; Nett M; Peduto A; Collarile S; Scuotto M; Roviezzo F; Spaziano G; de Rosa M; Stuppner H; Schuster D; D'Agostino B; Werz O
Biochem Pharmacol; 2016 Jul; 112():60-71. PubMed ID: 27157409
[TBL] [Abstract][Full Text] [Related]
13. Structure-based discovery of inhibitors of microsomal prostaglandin E2 synthase-1, 5-lipoxygenase and 5-lipoxygenase-activating protein: promising hits for the development of new anti-inflammatory agents.
De Simone R; Chini MG; Bruno I; Riccio R; Mueller D; Werz O; Bifulco G
J Med Chem; 2011 Mar; 54(6):1565-75. PubMed ID: 21323313
[TBL] [Abstract][Full Text] [Related]
14. Evaluation of Dual 5-Lipoxygenase/Microsomal Prostaglandin E2 Synthase-1 Inhibitory Effect of Natural and Synthetic Acronychia-Type Isoprenylated Acetophenones.
Svouraki A; Garscha U; Kouloura E; Pace S; Pergola C; Krauth V; Rossi A; Sautebin L; Halabalaki M; Werz O; Gaboriaud-Kolar N; Skaltsounis AL
J Nat Prod; 2017 Mar; 80(3):699-706. PubMed ID: 28240894
[TBL] [Abstract][Full Text] [Related]
15. Inhibitory effects of maesanin and analogs on arachidonic acid metabolizing enzymes.
Abourashed EA; Muhammad I; Resch M; Bauer R; el-Feraly FS; Hufford CD
Planta Med; 2001 Jun; 67(4):360-1. PubMed ID: 11458456
[TBL] [Abstract][Full Text] [Related]
16. Structure-activity relationships of (E)-3-(1,4-benzoquinonyl)-2-[(3-pyridyl)-alkyl]-2-propenoic acid derivatives that inhibit both 5-lipoxygenase and thromboxane A2 synthetase.
Hibi S; Okamoto Y; Tagami K; Numata H; Kobayashi N; Shinoda M; Kawahara T; Harada K; Miyamoto K; Yamatsu I
J Med Chem; 1996 Aug; 39(16):3148-57. PubMed ID: 8759636
[TBL] [Abstract][Full Text] [Related]
17. Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.
Koeberle A; Zettl H; Greiner C; Wurglics M; Schubert-Zsilavecz M; Werz O
J Med Chem; 2008 Dec; 51(24):8068-76. PubMed ID: 19053751
[TBL] [Abstract][Full Text] [Related]
18. Discovery of a benzenesulfonamide-based dual inhibitor of microsomal prostaglandin E
Cheung SY; Werner M; Esposito L; Troisi F; Cantone V; Liening S; König S; Gerstmeier J; Koeberle A; Bilancia R; Rizza R; Rossi A; Roviezzo F; Temml V; Schuster D; Stuppner H; Schubert-Zsilavecz M; Werz O; Hanke T; Pace S
Eur J Med Chem; 2018 Aug; 156():815-830. PubMed ID: 30053720
[TBL] [Abstract][Full Text] [Related]
19. Further studies on ethyl 5-hydroxy-indole-3-carboxylate scaffold: design, synthesis and evaluation of 2-phenylthiomethyl-indole derivatives as efficient inhibitors of human 5-lipoxygenase.
Peduto A; Bruno F; Dehm F; Krauth V; de Caprariis P; Weinigel C; Barz D; Massa A; De Rosa M; Werz O; Filosa R
Eur J Med Chem; 2014 Jun; 81():492-8. PubMed ID: 24871899
[TBL] [Abstract][Full Text] [Related]
20. Synthesis, inhibitory activity and in silico docking of dual COX/5-LOX inhibitors with quinone and resorcinol core.
Sisa M; Dvorakova M; Temml V; Jarosova V; Vanek T; Landa P
Eur J Med Chem; 2020 Oct; 204():112620. PubMed ID: 32738413
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]