223 related articles for article (PubMed ID: 25765759)
21. Modified acidic nonsteroidal anti-inflammatory drugs as dual inhibitors of mPGES-1 and 5-LOX.
Elkady M; Nieß R; Schaible AM; Bauer J; Luderer S; Ambrosi G; Werz O; Laufer SA
J Med Chem; 2012 Oct; 55(20):8958-62. PubMed ID: 22992107
[TBL] [Abstract][Full Text] [Related]
22. Exploring the role of chloro and methyl substitutions in 2-phenylthiomethyl-benzoindole derivatives for 5-LOX enzyme inhibition.
Peduto A; Krauth V; Collarile S; Dehm F; Ambruosi M; Belardo C; Guida F; Massa A; Esposito V; Maione S; de Rosa M; Werz O; Filosa R
Eur J Med Chem; 2016 Jan; 108():466-475. PubMed ID: 26708113
[TBL] [Abstract][Full Text] [Related]
23. Structural insight into the optimization of ethyl 5-hydroxybenzo[g]indol-3-carboxylates and their bioisosteric analogues as 5-LO/m-PGES-1 dual inhibitors able to suppress inflammation.
Bruno F; Errico S; Pace S; Nawrozkij MB; Mkrtchyan AS; Guida F; Maisto R; Olgaç A; D'Amico M; Maione S; De Rosa M; Banoglu E; Werz O; Fiorentino A; Filosa R
Eur J Med Chem; 2018 Jul; 155():946-960. PubMed ID: 30015253
[TBL] [Abstract][Full Text] [Related]
24. Identification of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinol.
Koeberle A; Northoff H; Werz O
Biochem Pharmacol; 2009 May; 77(9):1513-21. PubMed ID: 19426689
[TBL] [Abstract][Full Text] [Related]
25. Caulerpenyne and related bis-enol esters are novel-type inhibitors of human 5-lipoxygenase.
Richter P; Schubert G; Schaible AM; Cavas L; Werz O; Pohnert G
ChemMedChem; 2014 Aug; 9(8):1655-9. PubMed ID: 24729578
[TBL] [Abstract][Full Text] [Related]
26. [Inhibition of the arachidonic acid cascade by aza-2-aryl-1,4-naphthoquinone derivatives].
Richwien A; Wurm G
Pharmazie; 2004 Dec; 59(12):906-12. PubMed ID: 15638076
[TBL] [Abstract][Full Text] [Related]
27. Development of novel aminothiazole-comprising 5-LO inhibitors.
M Kretschmer SB; Woltersdorf S; Rödl CB; Vogt D; Häfner AK; Steinhilber D; Stark H; Hofmann B
Future Med Chem; 2016; 8(2):149-64. PubMed ID: 26824797
[TBL] [Abstract][Full Text] [Related]
28. Structure-activity relationship and in vitro pharmacological evaluation of imidazo[1,2-a]pyridine-based inhibitors of 5-LO.
Buscató El; Wisniewska JM; Rödl CB; Brüggerhoff A; Kaiser A; Rörsch F; Kostewicz E; Wurglics M; Schubert-Zsilavecz M; Grösch S; Steinhilber D; Hofmann B; Proschak E
Future Med Chem; 2013 May; 5(8):865-80. PubMed ID: 23682565
[TBL] [Abstract][Full Text] [Related]
29. Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase.
Karg EM; Luderer S; Pergola C; Bühring U; Rossi A; Northoff H; Sautebin L; Troschütz R; Werz O
J Med Chem; 2009 Jun; 52(11):3474-83. PubMed ID: 19492852
[TBL] [Abstract][Full Text] [Related]
30. Synthesis and biological evaluation of a class of 5-benzylidene-2-phenyl-thiazolinones as potent 5-lipoxygenase inhibitors.
Barzen S; Rödl CB; Lill A; Steinhilber D; Stark H; Hofmann B
Bioorg Med Chem; 2012 Jun; 20(11):3575-83. PubMed ID: 22551629
[TBL] [Abstract][Full Text] [Related]
31. Arylpyrrolizines as inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1) or as dual inhibitors of mPGES-1 and 5-lipoxygenase (5-LOX).
Liedtke AJ; Keck PR; Lehmann F; Koeberle A; Werz O; Laufer SA
J Med Chem; 2009 Aug; 52(15):4968-72. PubMed ID: 19719242
[TBL] [Abstract][Full Text] [Related]
32. SAR-study on a new class of imidazo[1,2-a]pyridine-based inhibitors of 5-lipoxygenase.
Hieke M; Rödl CB; Wisniewska JM; la Buscató E; Stark H; Schubert-Zsilavecz M; Steinhilber D; Hofmann B; Proschak E
Bioorg Med Chem Lett; 2012 Mar; 22(5):1969-75. PubMed ID: 22326163
[TBL] [Abstract][Full Text] [Related]
33. Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors.
De Lucia D; Lucio OM; Musio B; Bender A; Listing M; Dennhardt S; Koeberle A; Garscha U; Rizzo R; Manfredini S; Werz O; Ley SV
Eur J Med Chem; 2015 Aug; 101():573-83. PubMed ID: 26197161
[TBL] [Abstract][Full Text] [Related]
34. Benzo[d]isothiazole 1,1-dioxide derivatives as dual functional inhibitors of 5-lipoxygenase and microsomal prostaglandin E(2) synthase-1.
Shang E; Wu Y; Liu P; Liu Y; Zhu W; Deng X; He C; He S; Li C; Lai L
Bioorg Med Chem Lett; 2014 Jun; 24(12):2764-7. PubMed ID: 24794107
[TBL] [Abstract][Full Text] [Related]
35. New Zileuton-Hydroxycinnamic Acid Hybrids: Synthesis and Structure-Activity Relationship towards 5-Lipoxygenase Inhibition.
Chiasson AI; Robichaud S; Ndongou Moutombi FJ; Hébert MPA; Mbarik M; Surette ME; Touaibia M
Molecules; 2020 Oct; 25(20):. PubMed ID: 33066378
[TBL] [Abstract][Full Text] [Related]
36. Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid.
Werz O; Greiner C; Koeberle A; Hoernig C; George S; Popescu L; Syha I; Schubert-Zsilavecz M; Steinhilber D
J Med Chem; 2008 Sep; 51(17):5449-53. PubMed ID: 18710209
[TBL] [Abstract][Full Text] [Related]
37. SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.
Koeberle A; Muñoz E; Appendino GB; Minassi A; Pace S; Rossi A; Weinigel C; Barz D; Sautebin L; Caprioglio D; Collado JA; Werz O
J Med Chem; 2014 Jul; 57(13):5638-48. PubMed ID: 24920381
[TBL] [Abstract][Full Text] [Related]
38. 2-arylalkyl-substituted anthracenones as inhibitors of 12-lipoxygenase enzymes. 1. Structure-activity relationships of the terminal aryl ring.
Müller K; Altmann R; Prinz H
Eur J Med Chem; 2001 Jun; 36(6):569-75. PubMed ID: 11525848
[TBL] [Abstract][Full Text] [Related]
39. Inhibition of human 5-lipoxygenase and anti-neoplastic effects by 2-amino-1,4-benzoquinones.
Poeckel D; Niedermeyer TH; Pham HT; Mikolasch A; Mundt S; Lindequist U; Lalk M; Werz O
Med Chem; 2006 Nov; 2(6):591-5. PubMed ID: 17105440
[TBL] [Abstract][Full Text] [Related]
40. Syntheses and evaluation of novel isoliquiritigenin derivatives as potential dual inhibitors for amyloid-beta aggregation and 5-lipoxygenase.
Chen YP; Zhang ZY; Li YP; Li D; Huang SL; Gu LQ; Xu J; Huang ZS
Eur J Med Chem; 2013 Aug; 66():22-31. PubMed ID: 23786711
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]