BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

125 related articles for article (PubMed ID: 25778746)

  • 1. Evaluation of N-acetyl-S-(p-chlorophenylcarbamoyl)cysteine as an irreversible inhibitor of mammalian thioredoxin reductase1.
    Chen W; Jiang Z; Lin N; Zheng Z; Chen Z; Zhang X; Guan X
    J Enzyme Inhib Med Chem; 2016; 31(2):229-35. PubMed ID: 25778746
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Inhibition of mammalian thioredoxin reductase by black tea and its constituents: implications for anticancer actions.
    Du Y; Wu Y; Cao X; Cui W; Zhang H; Tian W; Ji M; Holmgren A; Zhong L
    Biochimie; 2009 Mar; 91(3):434-44. PubMed ID: 19059456
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Ethaselen: a potent mammalian thioredoxin reductase 1 inhibitor and novel organoselenium anticancer agent.
    Wang L; Yang Z; Fu J; Yin H; Xiong K; Tan Q; Jin H; Li J; Wang T; Tang W; Yin J; Cai G; Liu M; Kehr S; Becker K; Zeng H
    Free Radic Biol Med; 2012 Mar; 52(5):898-908. PubMed ID: 22210352
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Sublethal concentrations of diverse gold compounds inhibit mammalian cytosolic thioredoxin reductase (TrxR1).
    Omata Y; Folan M; Shaw M; Messer RL; Lockwood PE; Hobbs D; Bouillaguet S; Sano H; Lewis JB; Wataha JC
    Toxicol In Vitro; 2006 Sep; 20(6):882-90. PubMed ID: 16510263
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity.
    Fang J; Lu J; Holmgren A
    J Biol Chem; 2005 Jul; 280(26):25284-90. PubMed ID: 15879598
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Mammalian thioredoxin reductase is irreversibly inhibited by dinitrohalobenzenes by alkylation of both the redox active selenocysteine and its neighboring cysteine residue.
    Nordberg J; Zhong L; Holmgren A; Arnér ES
    J Biol Chem; 1998 May; 273(18):10835-42. PubMed ID: 9556556
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inhibitory nitrosylation of mammalian thioredoxin reductase 1: Molecular characterization and evidence for its functional role in cellular nitroso-redox imbalance.
    Engelman R; Ziv T; Arnér ESJ; Benhar M
    Free Radic Biol Med; 2016 Aug; 97():375-385. PubMed ID: 27377780
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design, synthesis, and biological evaluation of N-acetyl-S-(p-chlorophenylcarbamoyl)cysteine and its analogs as a novel class of anticancer agents.
    Chen W; Seefeldt T; Young A; Zhang X; Guan X
    Bioorg Med Chem; 2011 Jan; 19(1):287-94. PubMed ID: 21131205
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Oxidation of structural cysteine residues in thioredoxin 1 by aromatic arsenicals enhances cancer cell cytotoxicity caused by the inhibition of thioredoxin reductase 1.
    Zhang X; Lu J; Ren X; Du Y; Zheng Y; Ioannou PV; Holmgren A
    Free Radic Biol Med; 2015 Dec; 89():192-200. PubMed ID: 26169724
    [TBL] [Abstract][Full Text] [Related]  

  • 10. N‑acetyl-S-(p-chlorophenylcarbamoyl)cysteine induces mitochondrial-mediated apoptosis and suppresses migration in melanoma cells.
    Chen W; Jiang Z; Zhang X; Feng J; Ling Y
    Oncol Rep; 2015 Nov; 34(5):2547-56. PubMed ID: 26351874
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The anticancer agent chaetocin is a competitive substrate and inhibitor of thioredoxin reductase.
    Tibodeau JD; Benson LM; Isham CR; Owen WG; Bible KC
    Antioxid Redox Signal; 2009 May; 11(5):1097-106. PubMed ID: 18999987
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay.
    Prast-Nielsen S; Dexheimer TS; Schultz L; Stafford WC; Cheng Q; Xu J; Jadhav A; Arnér ES; Simeonov A
    Free Radic Biol Med; 2011 May; 50(9):1114-23. PubMed ID: 21262347
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Mechanistic insights into the inhibitory effects of palmitoylation on cytosolic thioredoxin reductase and thioredoxin.
    Qin H; Liang W; Xu Z; Ye F; Li X; Zhong L
    Biochimie; 2015 Mar; 110():25-35. PubMed ID: 25576832
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A diterpenoid derivate compound targets selenocysteine of thioredoxin reductases and induces Bax/Bak-independent apoptosis.
    Liu J; Mu C; Yue W; Li J; Ma B; Zhao L; Liu L; Chen Q; Yan C; Liu H; Hao X; Zhu Y
    Free Radic Biol Med; 2013 Oct; 63():485-94. PubMed ID: 23732520
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H
    Dagnell M; Pace PE; Cheng Q; Frijhoff J; Östman A; Arnér ESJ; Hampton MB; Winterbourn CC
    J Biol Chem; 2017 Sep; 292(35):14371-14380. PubMed ID: 28684416
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Noble metal targeting of thioredoxin reductase--covalent complexes with thioredoxin and thioredoxin-related protein of 14 kDa triggered by cisplatin.
    Prast-Nielsen S; Cebula M; Pader I; Arnér ES
    Free Radic Biol Med; 2010 Dec; 49(11):1765-78. PubMed ID: 20851179
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Inhibitory effect of green tea extract and (-)-epigallocatechin-3-gallate on mammalian thioredoxin reductase and HeLa cell viability.
    Wang Y; Zhang H; Holmgren A; Tian W; Zhong L
    Oncol Rep; 2008 Dec; 20(6):1479-87. PubMed ID: 19020731
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Cross-linking of thioredoxin reductase by the sulfur mustard analogue mechlorethamine (methylbis(2-chloroethyl)amine) in human lung epithelial cells and rat lung: selective inhibition of disulfide reduction but not redox cycling.
    Jan YH; Heck DE; Malaviya R; Casillas RP; Laskin DL; Laskin JD
    Chem Res Toxicol; 2014 Jan; 27(1):61-75. PubMed ID: 24274902
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Susceptibility of the antioxidant selenoenyzmes thioredoxin reductase and glutathione peroxidase to alkylation-mediated inhibition by anticancer acylfulvenes.
    Liu X; Pietsch KE; Sturla SJ
    Chem Res Toxicol; 2011 May; 24(5):726-36. PubMed ID: 21443269
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Mammalian thioredoxin reductase: oxidation of the C-terminal cysteine/selenocysteine active site forms a thioselenide, and replacement of selenium with sulfur markedly reduces catalytic activity.
    Lee SR; Bar-Noy S; Kwon J; Levine RL; Stadtman TC; Rhee SG
    Proc Natl Acad Sci U S A; 2000 Mar; 97(6):2521-6. PubMed ID: 10688911
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.