244 related articles for article (PubMed ID: 25799074)
1. Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.
Chen P; Chaikuad A; Bamborough P; Bantscheff M; Bountra C; Chung CW; Fedorov O; Grandi P; Jung D; Lesniak R; Lindon M; Müller S; Philpott M; Prinjha R; Rogers C; Selenski C; Tallant C; Werner T; Willson TM; Knapp S; Drewry DH
J Med Chem; 2016 Feb; 59(4):1410-24. PubMed ID: 25799074
[TBL] [Abstract][Full Text] [Related]
2. Reevaluation of bromodomain ligands targeting BAZ2A.
Cazzanelli G; Vedove AD; Parolin E; D'Agostino VG; Unzue A; Nevado C; Caflisch A; Lolli G
Protein Sci; 2023 Sep; 32(9):e4752. PubMed ID: 37574751
[TBL] [Abstract][Full Text] [Related]
3. Structure enabled design of BAZ2-ICR, a chemical probe targeting the bromodomains of BAZ2A and BAZ2B.
Drouin L; McGrath S; Vidler LR; Chaikuad A; Monteiro O; Tallant C; Philpott M; Rogers C; Fedorov O; Liu M; Akhtar W; Hayes A; Raynaud F; Müller S; Knapp S; Hoelder S
J Med Chem; 2015 Mar; 58(5):2553-9. PubMed ID: 25719566
[TBL] [Abstract][Full Text] [Related]
4. Structural Analysis of Small-Molecule Binding to the BAZ2A and BAZ2B Bromodomains.
Dalle Vedove A; Spiliotopoulos D; D'Agostino VG; Marchand JR; Unzue A; Nevado C; Lolli G; Caflisch A
ChemMedChem; 2018 Jul; 13(14):1479-1487. PubMed ID: 29770599
[TBL] [Abstract][Full Text] [Related]
5. GSK2801, a BAZ2/BRD9 Bromodomain Inhibitor, Synergizes with BET Inhibitors to Induce Apoptosis in Triple-Negative Breast Cancer.
Bevill SM; Olivares-Quintero JF; Sciaky N; Golitz BT; Singh D; Beltran AS; Rashid NU; Stuhlmiller TJ; Hale A; Moorman NJ; Santos CM; Angus SP; Zawistowski JS; Johnson GL
Mol Cancer Res; 2019 Jul; 17(7):1503-1518. PubMed ID: 31000582
[TBL] [Abstract][Full Text] [Related]
6. Identification of a BAZ2A Bromodomain Hit Compound by Fragment Joining.
Dalle Vedove A; Cazzanelli G; Corsi J; Sedykh M; D'Agostino VG; Caflisch A; Lolli G
ACS Bio Med Chem Au; 2021 Dec; 1(1):5-10. PubMed ID: 36147311
[TBL] [Abstract][Full Text] [Related]
7. Discovery of BAZ2A bromodomain ligands.
Spiliotopoulos D; Wamhoff EC; Lolli G; Rademacher C; Caflisch A
Eur J Med Chem; 2017 Oct; 139():564-572. PubMed ID: 28837921
[TBL] [Abstract][Full Text] [Related]
8. Recognition of hyperacetylated N-terminus of H2AZ by TbBDF2 from
Yang X; Wu X; Zhang J; Zhang X; Xu C; Liao S; Tu X
Biochem J; 2017 Nov; 474(22):3817-3830. PubMed ID: 29025975
[TBL] [Abstract][Full Text] [Related]
9. Binding Selectivity of Inhibitors toward Bromodomains BAZ2A and BAZ2B Uncovered by Multiple Short Molecular Dynamics Simulations and MM-GBSA Calculations.
Wang L; Wang Y; Yang Z; Xu S; Li H
ACS Omega; 2021 May; 6(18):12036-12049. PubMed ID: 34056358
[TBL] [Abstract][Full Text] [Related]
10. Disrupting Acetyl-Lysine Recognition: Progress in the Development of Bromodomain Inhibitors.
Romero FA; Taylor AM; Crawford TD; Tsui V; Côté A; Magnuson S
J Med Chem; 2016 Feb; 59(4):1271-98. PubMed ID: 26572217
[TBL] [Abstract][Full Text] [Related]
11. The "Gatekeeper" Residue Influences the Mode of Binding of Acetyl Indoles to Bromodomains.
Unzue A; Zhao H; Lolli G; Dong J; Zhu J; Zechner M; Dolbois A; Caflisch A; Nevado C
J Med Chem; 2016 Apr; 59(7):3087-97. PubMed ID: 26982797
[TBL] [Abstract][Full Text] [Related]
12. Chemical Proteomic Profiling of Bromodomains Enables the Wide-Spectrum Evaluation of Bromodomain Inhibitors in Living Cells.
Li X; Wu Y; Tian G; Jiang Y; Liu Z; Meng X; Bao X; Feng L; Sun H; Deng H; Li XD
J Am Chem Soc; 2019 Jul; 141(29):11497-11505. PubMed ID: 31246451
[TBL] [Abstract][Full Text] [Related]
13. High-Throughput Fragment Docking into the BAZ2B Bromodomain: Efficient in Silico Screening for X-Ray Crystallography.
Lolli G; Caflisch A
ACS Chem Biol; 2016 Mar; 11(3):800-7. PubMed ID: 26942307
[TBL] [Abstract][Full Text] [Related]
14. GSK2801 Reverses Paclitaxel Resistance in Anaplastic Thyroid Cancer Cell Lines through MYCN Downregulation.
Molteni E; Baldan F; Damante G; Allegri L
Int J Mol Sci; 2023 Mar; 24(6):. PubMed ID: 36983070
[TBL] [Abstract][Full Text] [Related]
15. Selective recognition of acetylated histones by bromodomains in transcriptional co-activators.
Hassan AH; Awad S; Al-Natour Z; Othman S; Mustafa F; Rizvi TA
Biochem J; 2007 Feb; 402(1):125-33. PubMed ID: 17049045
[TBL] [Abstract][Full Text] [Related]
16. Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain.
Ferguson FM; Fedorov O; Chaikuad A; Philpott M; Muniz JR; Felletar I; von Delft F; Heightman T; Knapp S; Abell C; Ciulli A
J Med Chem; 2013 Dec; 56(24):10183-7. PubMed ID: 24304323
[TBL] [Abstract][Full Text] [Related]
17. Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching.
Philpott M; Rogers CM; Yapp C; Wells C; Lambert JP; Strain-Damerell C; Burgess-Brown NA; Gingras AC; Knapp S; Müller S
Epigenetics Chromatin; 2014; 7():14. PubMed ID: 25097667
[TBL] [Abstract][Full Text] [Related]
18. Application of Atypical Acetyl-lysine Methyl Mimetics in the Development of Selective Inhibitors of the Bromodomain-Containing Protein 7 (BRD7)/Bromodomain-Containing Protein 9 (BRD9) Bromodomains.
Clegg MA; Bamborough P; Chung CW; Craggs PD; Gordon L; Grandi P; Leveridge M; Lindon M; Liwicki GM; Michon AM; Molnar J; Rioja I; Soden PE; Theodoulou NH; Werner T; Tomkinson NCO; Prinjha RK; Humphreys PG
J Med Chem; 2020 Jun; 63(11):5816-5840. PubMed ID: 32410449
[TBL] [Abstract][Full Text] [Related]
19. Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit.
Gerstenberger BS; Trzupek JD; Tallant C; Fedorov O; Filippakopoulos P; Brennan PE; Fedele V; Martin S; Picaud S; Rogers C; Parikh M; Taylor A; Samas B; O'Mahony A; Berg E; Pallares G; Torrey AD; Treiber DK; Samardjiev IJ; Nasipak BT; Padilla-Benavides T; Wu Q; Imbalzano AN; Nickerson JA; Bunnage ME; Müller S; Knapp S; Owen DR
J Med Chem; 2016 May; 59(10):4800-11. PubMed ID: 27115555
[TBL] [Abstract][Full Text] [Related]
20. Structural basis of the TAM domain of BAZ2A in binding to DNA or RNA independent of methylation status.
Chen S; Zhou M; Dong A; Loppnau P; Wang M; Min J; Liu K
J Biol Chem; 2021 Dec; 297(6):101351. PubMed ID: 34715126
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]