These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
122 related articles for article (PubMed ID: 25801008)
1. Slow R-warfarin 7-hydroxylation mediated by P450 2C19 genetic variants in cynomolgus monkeys in vivo. Utoh M; Yoshikawa T; Hayashi Y; Shimizu M; Iwasaki K; Uno Y; Yamazaki H Biochem Pharmacol; 2015 May; 95(2):110-4. PubMed ID: 25801008 [TBL] [Abstract][Full Text] [Related]
2. Oxidation of R- and S-omeprazole stereoselectively mediated by liver microsomal cytochrome P450 2C19 enzymes from cynomolgus monkeys and common marmosets. Uehara S; Kawano M; Murayama N; Uno Y; Utoh M; Inoue T; Sasaki E; Yamazaki H Biochem Pharmacol; 2016 Nov; 120():56-62. PubMed ID: 27641812 [TBL] [Abstract][Full Text] [Related]
3. R-warfarin clearances from plasma associated with polymorphic cytochrome P450 2C19 and simulated by individual physiologically based pharmacokinetic models for 11 cynomolgus monkeys. Utoh M; Kusama T; Miura T; Mitsui M; Kawano M; Hirano T; Shimizu M; Uno Y; Yamazaki H Xenobiotica; 2018 Feb; 48(2):206-210. PubMed ID: 28136132 [TBL] [Abstract][Full Text] [Related]
4. Individual Differences in Metabolic Clearance of S-Warfarin Efficiently Mediated by Polymorphic Marmoset Cytochrome P450 2C19 in Livers. Uehara S; Uno Y; Inoue T; Kawano M; Shimizu M; Toda A; Utoh M; Sasaki E; Yamazaki H Drug Metab Dispos; 2016 Jul; 44(7):911-5. PubMed ID: 27098744 [TBL] [Abstract][Full Text] [Related]
5. CYP2C19 polymorphisms account for inter-individual variability of drug metabolism in cynomolgus macaques. Uno Y; Matsushita A; Shukuya M; Matsumoto Y; Murayama N; Yamazaki H Biochem Pharmacol; 2014 Sep; 91(2):242-8. PubMed ID: 25036290 [TBL] [Abstract][Full Text] [Related]
6. Monkey liver cytochrome P450 2C19 is involved in R- and S-warfarin 7-hydroxylation. Hosoi Y; Uno Y; Murayama N; Fujino H; Shukuya M; Iwasaki K; Shimizu M; Utoh M; Yamazaki H Biochem Pharmacol; 2012 Dec; 84(12):1691-5. PubMed ID: 23041648 [TBL] [Abstract][Full Text] [Related]
7. Genetic polymorphisms of drug-metabolizing cytochrome P450 enzymes in cynomolgus and rhesus monkeys and common marmosets in preclinical studies for humans. Uno Y; Uehara S; Yamazaki H Biochem Pharmacol; 2018 Jul; 153():184-195. PubMed ID: 29277691 [TBL] [Abstract][Full Text] [Related]
8. Novel Marmoset Cytochrome P450 2C19 in Livers Efficiently Metabolizes Human P450 2C9 and 2C19 Substrates, S-Warfarin, Tolbutamide, Flurbiprofen, and Omeprazole. Uehara S; Uno Y; Inoue T; Kawano M; Shimizu M; Toda A; Utoh M; Sasaki E; Yamazaki H Drug Metab Dispos; 2015 Oct; 43(10):1408-16. PubMed ID: 26228688 [TBL] [Abstract][Full Text] [Related]
9. Association with polymorphic marmoset cytochrome P450 2C19 of in vivo hepatic clearances of chirally separated R-omeprazole and S-warfarin using individual marmoset physiologically based pharmacokinetic models. Kusama T; Toda A; Shimizu M; Uehara S; Inoue T; Uno Y; Utoh M; Sasaki E; Yamazaki H Xenobiotica; 2018 Oct; 48(10):1072-1077. PubMed ID: 29034770 [TBL] [Abstract][Full Text] [Related]
10. Similar substrate specificity of cynomolgus monkey cytochrome P450 2C19 to reported human P450 2C counterpart enzymes by evaluation of 89 drug clearances. Hosaka S; Murayama N; Satsukawa M; Uehara S; Shimizu M; Iwasaki K; Iwano S; Uno Y; Yamazaki H Biopharm Drug Dispos; 2015 Dec; 36(9):636-43. PubMed ID: 26348733 [TBL] [Abstract][Full Text] [Related]
11. Age-related changes of hepatic clearances of cytochrome P450 probes, midazolam and R-/S-warfarin in combination with caffeine, omeprazole and metoprolol in cynomolgus monkeys using in vitro-in vivo correlation. Koyanagi T; Nakanishi Y; Murayama N; Yamaura Y; Ikeda K; Yano K; Uehara S; Utoh M; Kim S; Uno Y; Yamazaki H Xenobiotica; 2015 Apr; 45(4):312-21. PubMed ID: 25364857 [TBL] [Abstract][Full Text] [Related]
12. Utility of non-human primates in drug development: Comparison of non-human primate and human drug-metabolizing cytochrome P450 enzymes. Uno Y; Uehara S; Yamazaki H Biochem Pharmacol; 2016 Dec; 121():1-7. PubMed ID: 27318253 [TBL] [Abstract][Full Text] [Related]
13. In vivo individual variations in pharmacokinetics of efavirenz in cynomolgus monkeys genotyped for cytochrome P450 2C9. Iwasaki K; Kitsugi Y; Ikeda K; Yoshikawa T; Hosaka S; Uehara S; Uno Y; Utoh M; Yamazaki H Biopharm Drug Dispos; 2016 Sep; 37(6):379-83. PubMed ID: 27417918 [TBL] [Abstract][Full Text] [Related]
14. Human plasma concentrations of cytochrome P450 probes extrapolated from pharmacokinetics in cynomolgus monkeys using physiologically based pharmacokinetic modeling. Shida S; Utoh M; Murayama N; Shimizu M; Uno Y; Yamazaki H Xenobiotica; 2015; 45(10):881-6. PubMed ID: 26075833 [TBL] [Abstract][Full Text] [Related]
15. Cytochrome P450 1A1, 2C9, 2C19, and 3A4 Polymorphisms Account for Interindividual Variability of Toxicological Drug Metabolism in Cynomolgus Macaques. Uno Y; Uehara S; Murayama N; Yamazaki H Chem Res Toxicol; 2018 Dec; 31(12):1373-1381. PubMed ID: 30412386 [TBL] [Abstract][Full Text] [Related]
16. Development of a genotyping tool for a functionally relevant CYP2C19 allele (Phe100Asn, Ala103Val and Ile112Leu) in cynomolgus macaques. Uno Y; Yamazaki H J Vet Med Sci; 2016 Jan; 78(1):147-8. PubMed ID: 26300440 [TBL] [Abstract][Full Text] [Related]
17. Effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome P450 probes caffeine, warfarin, omeprazole, metoprolol and midazolam in common marmosets genotyped for cytochrome P450 2C19. Toda A; Uehara S; Inoue T; Utoh M; Kusama T; Shimizu M; Uno Y; Mogi M; Sasaki E; Yamazaki H Xenobiotica; 2018 Jul; 48(7):720-726. PubMed ID: 28686070 [TBL] [Abstract][Full Text] [Related]
18. The role of cytochrome P2C19 in R-warfarin pharmacokinetics and its interaction with omeprazole. Uno T; Sugimoto K; Sugawara K; Tateishi T Ther Drug Monit; 2008 Jun; 30(3):276-81. PubMed ID: 18520598 [TBL] [Abstract][Full Text] [Related]
19. Metabolism of warfarin enantiomers in Japanese patients with heart disease having different CYP2C9 and CYP2C19 genotypes. Takahashi H; Kashima T; Nomizo Y; Muramoto N; Shimizu T; Nasu K; Kubota T; Kimura S; Echizen H Clin Pharmacol Ther; 1998 May; 63(5):519-28. PubMed ID: 9630825 [TBL] [Abstract][Full Text] [Related]
20. In vivo and in vitro diclofenac 5-hydroxylation mediated primarily by cytochrome P450 3A enzymes in common marmoset livers genotyped for P450 2C19 variants. Nakanishi K; Uehara S; Kusama T; Inoue T; Shimura K; Kamiya Y; Murayama N; Shimizu M; Uno Y; Sasaki E; Yamazaki H Biochem Pharmacol; 2018 Jun; 152():272-278. PubMed ID: 29626440 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]