BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

152 related articles for article (PubMed ID: 25808135)

  • 1. Molecular modeling study of the induced-fit effect on kinase inhibition: the case of fibroblast growth factor receptor 3 (FGFR3).
    Li Y; Delamar M; Busca P; Prestat G; Le Corre L; Legeai-Mallet L; Hu R; Zhang R; Barbault F
    J Comput Aided Mol Des; 2015 Jul; 29(7):619-41. PubMed ID: 25808135
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A novel tyrosine kinase inhibitor restores chondrocyte differentiation and promotes bone growth in a gain-of-function Fgfr3 mouse model.
    Jonquoy A; Mugniery E; Benoist-Lasselin C; Kaci N; Le Corre L; Barbault F; Girard AL; Le Merrer Y; Busca P; Schibler L; Munnich A; Legeai-Mallet L
    Hum Mol Genet; 2012 Feb; 21(4):841-51. PubMed ID: 22072392
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery of octahydropyrrolo [3,2-b] pyridin derivative as a highly selective Type I inhibitor of FGFR3 over VEGFR2 by high-throughput virtual screening.
    Wang X; Ye CH; Li EM; Xu LY; Lin WQ; Chen GH
    J Cell Biochem; 2023 Feb; 124(2):221-238. PubMed ID: 36502529
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of tyrosine kinase inhibitors by docking into an inactive kinase conformation generated by molecular dynamics.
    Zhao H; Huang D; Caflisch A
    ChemMedChem; 2012 Nov; 7(11):1983-90. PubMed ID: 22976951
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis of purin-2-yl and purin-6-yl-aminoglucitols as C-nucleosidic ATP mimics and biological evaluation as FGFR3 inhibitors.
    Tak-Tak L; Barbault F; Maurel F; Busca P; Le Merrer Y
    Eur J Med Chem; 2011 Apr; 46(4):1254-62. PubMed ID: 21334122
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Molecular dynamics simulation and free energy calculation studies of kinase inhibitors binding to active and inactive conformations of VEGFR-2.
    Wu X; Wan S; Wang G; Jin H; Li Z; Tian Y; Zhu Z; Zhang J
    J Mol Graph Model; 2015 Mar; 56():103-12. PubMed ID: 25594497
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Role of the N-Terminal Transmembrane Helix Contacts in the Activation of FGFR3.
    Matsuoka D; Kamiya M; Sato T; Sugita Y
    J Comput Chem; 2020 Mar; 41(6):561-572. PubMed ID: 31804721
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Homology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification.
    Ke YY; Singh VK; Coumar MS; Hsu YC; Wang WC; Song JS; Chen CH; Lin WH; Wu SH; Hsu JT; Shih C; Hsieh HP
    Sci Rep; 2015 Jun; 5():11702. PubMed ID: 26118648
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Designing New Kinase Inhibitor Derivatives as Therapeutics Against Common Complex Diseases: Structural Basis of Microtubule Affinity-Regulating Kinase 4 (MARK4) Inhibition.
    Naz F; Shahbaaz M; Bisetty K; Islam A; Ahmad F; Hassan MI
    OMICS; 2015 Nov; 19(11):700-11. PubMed ID: 26565604
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Role of dimerization efficiency of transmembrane domains in activation of fibroblast growth factor receptor 3.
    Volynsky PE; Polyansky AA; Fakhrutdinova GN; Bocharov EV; Efremov RG
    J Am Chem Soc; 2013 Jun; 135(22):8105-8. PubMed ID: 23679838
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Identification of type-II inhibitors using kinase structures.
    Lovering F; McDonald J; Whitlock GA; Glossop PA; Phillips C; Bent A; Sabnis Y; Ryan M; Fitz L; Lee J; Chang JS; Han S; Kurumbail R; Thorarensen A
    Chem Biol Drug Des; 2012 Nov; 80(5):657-64. PubMed ID: 22759374
    [TBL] [Abstract][Full Text] [Related]  

  • 12. FGFR3 targeting strategies for achondroplasia.
    Laederich MB; Horton WA
    Expert Rev Mol Med; 2012 Jan; 14():e11. PubMed ID: 22559284
    [TBL] [Abstract][Full Text] [Related]  

  • 13. FGFR3 is overexpressed waldenstrom macroglobulinemia and its inhibition by Dovitinib induces apoptosis and overcomes stroma-induced proliferation.
    Azab AK; Azab F; Quang P; Maiso P; Sacco A; Ngo HT; Liu Y; Zhang Y; Morgan BL; Roccaro AM; Ghobrial IM
    Clin Cancer Res; 2011 Jul; 17(13):4389-99. PubMed ID: 21521775
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Transient dimerization and interaction with ERGIC-53 occur in the fibroblast growth factor receptor 3 early secretory pathway.
    Lievens PM; De Servi B; Garofalo S; Lunstrum GP; Horton WA; Liboi E
    Int J Biochem Cell Biol; 2008; 40(11):2649-59. PubMed ID: 18577465
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Effect of the achondroplasia mutation on FGFR3 dimerization and FGFR3 structural response to fgf1 and fgf2: A quantitative FRET study in osmotically derived plasma membrane vesicles.
    Sarabipour S; Hristova K
    Biochim Biophys Acta; 2016 Jul; 1858(7 Pt A):1436-42. PubMed ID: 27040652
    [TBL] [Abstract][Full Text] [Related]  

  • 16. In silico prediction and in vitro and in vivo validation of acaricide fluazuron as a potential inhibitor of FGFR3 and a candidate anticancer drug for bladder carcinoma.
    Ke K; Li H; Yao H; Shi XN; Dong C; Zhu Y; Liu X; Li L; Leung KS; Wong MH; Liu XD; Kung HF; Lin MC
    Chem Biol Drug Des; 2017 Apr; 89(4):505-513. PubMed ID: 27664399
    [TBL] [Abstract][Full Text] [Related]  

  • 17. 2-Oxo-3, 4-dihydropyrimido[4, 5-d]pyrimidinyl derivatives as new irreversible pan fibroblast growth factor receptor (FGFR) inhibitors.
    Li X; Guise CP; Taghipouran R; Yosaatmadja Y; Ashoorzadeh A; Paik WK; Squire CJ; Jiang S; Luo J; Xu Y; Tu ZC; Lu X; Ren X; Patterson AV; Smaill JB; Ding K
    Eur J Med Chem; 2017 Jul; 135():531-543. PubMed ID: 28521156
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Crosstalk between KIT and FGFR3 Promotes Gastrointestinal Stromal Tumor Cell Growth and Drug Resistance.
    Javidi-Sharifi N; Traer E; Martinez J; Gupta A; Taguchi T; Dunlap J; Heinrich MC; Corless CL; Rubin BP; Druker BJ; Tyner JW
    Cancer Res; 2015 Mar; 75(5):880-91. PubMed ID: 25432174
    [TBL] [Abstract][Full Text] [Related]  

  • 19. NMR backbone assignments of the tyrosine kinase domain of human fibroblast growth factor receptor 3 in apo state and in complex with inhibitor PD173074.
    Sanfelice D; Koss H; Bunney TD; Thompson GS; Farrell B; Katan M; Breeze AL
    Biomol NMR Assign; 2018 Oct; 12(2):231-235. PubMed ID: 29582384
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Conformational analysis of the DFG-out kinase motif and biochemical profiling of structurally validated type II inhibitors.
    Vijayan RS; He P; Modi V; Duong-Ly KC; Ma H; Peterson JR; Dunbrack RL; Levy RM
    J Med Chem; 2015 Jan; 58(1):466-79. PubMed ID: 25478866
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.