These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

138 related articles for article (PubMed ID: 25809253)

  • 1. NS1643 interacts around L529 of hERG to alter voltage sensor movement on the path to activation.
    Guo J; Cheng YM; Lees-Miller JP; Perissinotti LL; Claydon TW; Hull CM; Thouta S; Roach DE; Durdagi S; Noskov SY; Duff HJ
    Biophys J; 2015 Mar; 108(6):1400-1413. PubMed ID: 25809253
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Kinetic model for NS1643 drug activation of WT and L529I variants of Kv11.1 (hERG1) potassium channel.
    Perissinotti LL; Guo J; De Biase PM; Clancy CE; Duff HJ; Noskov SY
    Biophys J; 2015 Mar; 108(6):1414-1424. PubMed ID: 25809254
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure-guided topographic mapping and mutagenesis to elucidate binding sites for the human ether-a-go-go-related gene 1 potassium channel (KCNH2) activator NS1643.
    Durdagi S; Guo J; Lees-Miller JP; Noskov SY; Duff HJ
    J Pharmacol Exp Ther; 2012 Aug; 342(2):441-52. PubMed ID: 22573844
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mechanism of action of a novel human ether-a-go-go-related gene channel activator.
    Casis O; Olesen SP; Sanguinetti MC
    Mol Pharmacol; 2006 Feb; 69(2):658-65. PubMed ID: 16284303
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Molecular determinants of human ether-à-go-go-related gene 1 (hERG1) K+ channel activation by NS1643.
    Grunnet M; Abbruzzese J; Sachse FB; Sanguinetti MC
    Mol Pharmacol; 2011 Jan; 79(1):1-9. PubMed ID: 20876384
    [TBL] [Abstract][Full Text] [Related]  

  • 6. NS1643 enhances ionic currents in a G604S-WT hERG co-expression system associated with long QT syndrome 2.
    Huo J; Guo X; Lu Q; Qiang H; Liu P; Bai L; Huang CL; Zhang Y; Ma A
    Clin Exp Pharmacol Physiol; 2017 Nov; 44(11):1125-1133. PubMed ID: 28741726
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Activation of ERG2 potassium channels by the diphenylurea NS1643.
    Elmedyb P; Olesen SP; Grunnet M
    Neuropharmacology; 2007 Aug; 53(2):283-94. PubMed ID: 17610913
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643).
    Hansen RS; Diness TG; Christ T; Demnitz J; Ravens U; Olesen SP; Grunnet M
    Mol Pharmacol; 2006 Jan; 69(1):266-77. PubMed ID: 16219910
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Strong activation of ether-à-go-go-related gene 1 K+ channel isoforms by NS1643 in human embryonic kidney 293 and Chinese hamster ovary cells.
    Schuster AM; Glassmeier G; Bauer CK
    Mol Pharmacol; 2011 Nov; 80(5):930-42. PubMed ID: 21856740
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The human ether-a-go-go-related gene activator NS1643 enhances epilepsy-associated KCNQ channels.
    Li P; Chen X; Zhang Q; Zheng Y; Jiang H; Yang H; Gao Z
    J Pharmacol Exp Ther; 2014 Dec; 351(3):596-604. PubMed ID: 25232191
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels.
    Larsen AP; Bentzen BH; Grunnet M
    Br J Pharmacol; 2010 Oct; 161(3):614-28. PubMed ID: 20880400
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Potent activation of large-conductance Ca2+-activated K+ channels by the diphenylurea 1,3-bis-[2-hydroxy-5-(trifluoromethyl)phenyl]urea (NS1643) in pituitary tumor (GH3) cells.
    Wu SN; Peng H; Chen BS; Wang YJ; Wu PY; Lin MW
    Mol Pharmacol; 2008 Dec; 74(6):1696-704. PubMed ID: 18809671
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Probing the binding sites and mechanisms of action of two human ether-a-go-go-related gene channel activators, 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243).
    Xu X; Recanatini M; Roberti M; Tseng GN
    Mol Pharmacol; 2008 Jun; 73(6):1709-21. PubMed ID: 18372399
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Molecular basis of slow activation of the human ether-a-go-go related gene potassium channel.
    Subbiah RN; Clarke CE; Smith DJ; Zhao J; Campbell TJ; Vandenberg JI
    J Physiol; 2004 Jul; 558(Pt 2):417-31. PubMed ID: 15181157
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Pharmacological rescue of hERG currents carried out by G604S and wide type hERG co-expression.
    Huo J; Zhang A; Guo X; Qiang H; Liu P; Bai L; Ma A
    Clin Exp Pharmacol Physiol; 2016 Sep; 43(9):851-61. PubMed ID: 27199074
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Effects of the small molecule HERG activator NS1643 on Kv11.3 channels.
    Bilet A; Bauer CK
    PLoS One; 2012; 7(11):e50886. PubMed ID: 23226420
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Pharmacological activation of Kv11.1 in transgenic long QT-1 rabbits.
    Bentzen BH; Bahrke S; Wu K; Larsen AP; Odening KE; Franke G; Storm vańs Gravesande K; Biermann J; Peng X; Koren G; Zehender M; Bode C; Grunnet M; Brunner M
    J Cardiovasc Pharmacol; 2011 Feb; 57(2):223-30. PubMed ID: 21135701
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Computational analysis of the effects of the hERG channel opener NS1643 in a human ventricular cell model.
    Peitersen T; Grunnet M; Benson AP; Holden AV; Holstein-Rathlou NH; Olesen SP
    Heart Rhythm; 2008 May; 5(5):734-41. PubMed ID: 18452879
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structure driven design of novel human ether-a-go-go-related-gene channel (hERG1) activators.
    Guo J; Durdagi S; Changalov M; Perissinotti LL; Hargreaves JM; Back TG; Noskov SY; Duff HJ
    PLoS One; 2014; 9(9):e105553. PubMed ID: 25191697
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Tryptophan scanning mutagenesis of the HERG K+ channel: the S4 domain is loosely packed and likely to be lipid exposed.
    Subbiah RN; Kondo M; Campbell TJ; Vandenberg JI
    J Physiol; 2005 Dec; 569(Pt 2):367-79. PubMed ID: 16166152
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.