BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

597 related articles for article (PubMed ID: 25812965)

  • 1. Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease.
    Xie SS; Wang X; Jiang N; Yu W; Wang KD; Lan JS; Li ZR; Kong LY
    Eur J Med Chem; 2015 May; 95():153-65. PubMed ID: 25812965
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease.
    Joubert J; Foka GB; Repsold BP; Oliver DW; Kapp E; Malan SF
    Eur J Med Chem; 2017 Jan; 125():853-864. PubMed ID: 27744252
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Coumarin-dithiocarbamate hybrids as novel multitarget AChE and MAO-B inhibitors against Alzheimer's disease: Design, synthesis and biological evaluation.
    He Q; Liu J; Lan JS; Ding J; Sun Y; Fang Y; Jiang N; Yang Z; Sun L; Jin Y; Xie SS
    Bioorg Chem; 2018 Dec; 81():512-528. PubMed ID: 30245233
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design, synthesis and biological evaluation of novel donepezil-coumarin hybrids as multi-target agents for the treatment of Alzheimer's disease.
    Xie SS; Lan JS; Wang X; Wang ZM; Jiang N; Li F; Wu JJ; Wang J; Kong LY
    Bioorg Med Chem; 2016 Apr; 24(7):1528-39. PubMed ID: 26917219
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Design, synthesis and biological evaluation of novel coumarin-N-benzyl pyridinium hybrids as multi-target agents for the treatment of Alzheimer's disease.
    Lan JS; Ding Y; Liu Y; Kang P; Hou JW; Zhang XY; Xie SS; Zhang T
    Eur J Med Chem; 2017 Oct; 139():48-59. PubMed ID: 28797883
    [TBL] [Abstract][Full Text] [Related]  

  • 6. In vitro and in vivo Biological Evaluation of Newly Tacrine-Selegiline Hybrids as Multi-Target Inhibitors of Cholinesterases and Monoamine Oxidases for Alzheimer's Disease.
    Huang ST; Luo JC; Zhong GH; Teng LP; Yang CY; Tang CL; Jing L; Zhou ZB; Liu J; Jiang N
    Drug Des Devel Ther; 2024; 18():133-159. PubMed ID: 38283137
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and biological evaluation of novel tacrine derivatives and tacrine-coumarin hybrids as cholinesterase inhibitors.
    Hamulakova S; Janovec L; Hrabinova M; Spilovska K; Korabecny J; Kristian P; Kuca K; Imrich J
    J Med Chem; 2014 Aug; 57(16):7073-84. PubMed ID: 25089370
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design, synthesis and evaluation of novel tacrine-coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease.
    Xie SS; Wang XB; Li JY; Yang L; Kong LY
    Eur J Med Chem; 2013 Jun; 64():540-53. PubMed ID: 23685572
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids.
    Bautista-Aguilera OM; Esteban G; Chioua M; Nikolic K; Agbaba D; Moraleda I; Iriepa I; Soriano E; Samadi A; Unzeta M; Marco-Contelles J
    Drug Des Devel Ther; 2014; 8():1893-910. PubMed ID: 25378907
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Design, synthesis and evaluation of novel tacrine-(β-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease.
    Lan JS; Xie SS; Li SY; Pan LF; Wang XB; Kong LY
    Bioorg Med Chem; 2014 Nov; 22(21):6089-104. PubMed ID: 25282654
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids.
    Sun Y; Chen J; Chen X; Huang L; Li X
    Bioorg Med Chem; 2013 Dec; 21(23):7406-17. PubMed ID: 24128814
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Multifunctional tacrine-trolox hybrids for the treatment of Alzheimer's disease with cholinergic, antioxidant, neuroprotective and hepatoprotective properties.
    Xie SS; Lan JS; Wang XB; Jiang N; Dong G; Li ZR; Wang KD; Guo PP; Kong LY
    Eur J Med Chem; 2015 Mar; 93():42-50. PubMed ID: 25656088
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.
    Bautista-Aguilera OM; Esteban G; Bolea I; Nikolic K; Agbaba D; Moraleda I; Iriepa I; Samadi A; Soriano E; Unzeta M; Marco-Contelles J
    Eur J Med Chem; 2014 Mar; 75():82-95. PubMed ID: 24530494
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease.
    Wang L; Esteban G; Ojima M; Bautista-Aguilera OM; Inokuchi T; Moraleda I; Iriepa I; Samadi A; Youdim MB; Romero A; Soriano E; Herrero R; Fernández Fernández AP; Ricardo-Martínez-Murillo ; Marco-Contelles J; Unzeta M
    Eur J Med Chem; 2014 Jun; 80():543-61. PubMed ID: 24813882
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis and pharmacological evaluation of donepezil-based agents as new cholinesterase/monoamine oxidase inhibitors for the potential application against Alzheimer's disease.
    Li F; Wang ZM; Wu JJ; Wang J; Xie SS; Lan JS; Xu W; Kong LY; Wang XB
    J Enzyme Inhib Med Chem; 2016; 31(sup3):41-53. PubMed ID: 27384289
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The development of 2-acetylphenol-donepezil hybrids as multifunctional agents for the treatment of Alzheimer's disease.
    Zhu G; Wang K; Shi J; Zhang P; Yang D; Fan X; Zhang Z; Liu W; Sang Z
    Bioorg Med Chem Lett; 2019 Oct; 29(19):126625. PubMed ID: 31444085
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A novel series of tacrine-selegiline hybrids with cholinesterase and monoamine oxidase inhibition activities for the treatment of Alzheimer's disease.
    Lu C; Zhou Q; Yan J; Du Z; Huang L; Li X
    Eur J Med Chem; 2013 Apr; 62():745-53. PubMed ID: 23454517
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Novel AP2238-clorgiline hybrids as multi-target agents for the treatment of Alzheimer's disease: Design, synthesis, and biological evaluation.
    Zhong G; Guo J; Pang C; Su D; Tang C; Jing L; Zhang F; He P; Yan Y; Chen Z; Liu J; Jiang N
    Bioorg Chem; 2023 Jan; 130():106224. PubMed ID: 36332315
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.
    Samadi A; de los Ríos C; Bolea I; Chioua M; Iriepa I; Moraleda I; Bartolini M; Andrisano V; Gálvez E; Valderas C; Unzeta M; Marco-Contelles J
    Eur J Med Chem; 2012 Jun; 52():251-62. PubMed ID: 22503231
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.
    Bolea I; Juárez-Jiménez J; de Los Ríos C; Chioua M; Pouplana R; Luque FJ; Unzeta M; Marco-Contelles J; Samadi A
    J Med Chem; 2011 Dec; 54(24):8251-70. PubMed ID: 22023459
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 30.